Dr. Matthew Hill

And then the adverse effects when someone consumes too much and they have a negative response, that's probably due to the higher dose starting to saturate on the inhibitory neurons. Now, we obviously can never test something like that in humans because we can't know. But based on what we've seen in animals, that's...

And then the adverse effects when someone consumes too much and they have a negative response, that's probably due to the higher dose starting to saturate on the inhibitory neurons. Now, we obviously can never test something like that in humans because we can't know. But based on what we've seen in animals, that's...

And then the adverse effects when someone consumes too much and they have a negative response, that's probably due to the higher dose starting to saturate on the inhibitory neurons. Now, we obviously can never test something like that in humans because we can't know. But based on what we've seen in animals, that's...

my theory of kind of how this is working and why we see these kind of classic biphasic effects. So yeah, too much THC, not a good thing, because then you start maybe disinhibiting things like the amygdala and producing these kind of panicky, anxiogenic-like outcomes. On that scale though, I mean, paranoia, obviously that's a hard, I don't know how you study that in a rodent.

my theory of kind of how this is working and why we see these kind of classic biphasic effects. So yeah, too much THC, not a good thing, because then you start maybe disinhibiting things like the amygdala and producing these kind of panicky, anxiogenic-like outcomes. On that scale though, I mean, paranoia, obviously that's a hard, I don't know how you study that in a rodent.

my theory of kind of how this is working and why we see these kind of classic biphasic effects. So yeah, too much THC, not a good thing, because then you start maybe disinhibiting things like the amygdala and producing these kind of panicky, anxiogenic-like outcomes. On that scale though, I mean, paranoia, obviously that's a hard, I don't know how you study that in a rodent.

I mean, that's just a strange thing. So, but I mean, that's kind of the precedent of when you start going into the psychosis, because obviously paranoia would be a big component of that. Someone wants to ask me a question about, you know, have, you know, what happens in the brain, like imaging wise, when someone's having like a psychotic episode from cannabis?

I mean, that's just a strange thing. So, but I mean, that's kind of the precedent of when you start going into the psychosis, because obviously paranoia would be a big component of that. Someone wants to ask me a question about, you know, have, you know, what happens in the brain, like imaging wise, when someone's having like a psychotic episode from cannabis?

I mean, that's just a strange thing. So, but I mean, that's kind of the precedent of when you start going into the psychosis, because obviously paranoia would be a big component of that. Someone wants to ask me a question about, you know, have, you know, what happens in the brain, like imaging wise, when someone's having like a psychotic episode from cannabis?

And I was kind of thinking like, how would that study get done?

And I was kind of thinking like, how would that study get done?

And I was kind of thinking like, how would that study get done?

I can't actually even imagine how that would go down. So I'm like, this is something I don't think we're ever going to have an answer to because I don't think you can actually ever test it. But in terms of people having this kind of psychotic response, it is pretty... rare.

I can't actually even imagine how that would go down. So I'm like, this is something I don't think we're ever going to have an answer to because I don't think you can actually ever test it. But in terms of people having this kind of psychotic response, it is pretty... rare.

I can't actually even imagine how that would go down. So I'm like, this is something I don't think we're ever going to have an answer to because I don't think you can actually ever test it. But in terms of people having this kind of psychotic response, it is pretty... rare.

I mean, and I say this because I can think of in Canada, kind of whenever it's happened and someone has actually done something wildly unpredictable because they've had a psychotic response to cannabis, it tends to make headlines. So it's not common. I could not give you an actual number, but it's certainly not a frequent thing because we would hear about this a lot more if we did.

I mean, and I say this because I can think of in Canada, kind of whenever it's happened and someone has actually done something wildly unpredictable because they've had a psychotic response to cannabis, it tends to make headlines. So it's not common. I could not give you an actual number, but it's certainly not a frequent thing because we would hear about this a lot more if we did.

I mean, and I say this because I can think of in Canada, kind of whenever it's happened and someone has actually done something wildly unpredictable because they've had a psychotic response to cannabis, it tends to make headlines. So it's not common. I could not give you an actual number, but it's certainly not a frequent thing because we would hear about this a lot more if we did.

I wouldn't say... I mean, there's certainly... Cannabis is used in tandem with other drugs, alcohol, psychedelics at times for sure. But that being said, I mean, there is clearly a population of people that use cannabis as their only drug that they use. I don't think that's that uncommon. But in the context of the psychosis stuff, I would definitely say – Sure.

I wouldn't say... I mean, there's certainly... Cannabis is used in tandem with other drugs, alcohol, psychedelics at times for sure. But that being said, I mean, there is clearly a population of people that use cannabis as their only drug that they use. I don't think that's that uncommon. But in the context of the psychosis stuff, I would definitely say – Sure.