Dr. Matthew Walker

So this isn't even across companies. What about other technologies to artificially boost or improve sleep? Is there anything cool at the moment? Yeah, I think there is.

I mean, I think there are, you know, CBD, I think, is actually one of the potential contenders in this category of new emerging technologies pharmacologically. CBD, I think, is, we still don't have enough data I think the problem with CBD is that it is dose dependent.

I mean, I think there are, you know, CBD, I think, is actually one of the potential contenders in this category of new emerging technologies pharmacologically. CBD, I think, is, we still don't have enough data I think the problem with CBD is that it is dose dependent.

I mean, I think there are, you know, CBD, I think, is actually one of the potential contenders in this category of new emerging technologies pharmacologically. CBD, I think, is, we still don't have enough data I think the problem with CBD is that it is dose dependent.

If you look at the data, squint your eyes because there's not enough, and you make a non-scientific kind of guesstimation, anything less than about 25 milligrams seems to actually be wake promoting. Whereas anything that's about 50 milligrams or more may actually be sleep promoting. Even though it's the same drug. Compound. Same compound. So you get what's called a dose dependent response.

If you look at the data, squint your eyes because there's not enough, and you make a non-scientific kind of guesstimation, anything less than about 25 milligrams seems to actually be wake promoting. Whereas anything that's about 50 milligrams or more may actually be sleep promoting. Even though it's the same drug. Compound. Same compound. So you get what's called a dose dependent response.

If you look at the data, squint your eyes because there's not enough, and you make a non-scientific kind of guesstimation, anything less than about 25 milligrams seems to actually be wake promoting. Whereas anything that's about 50 milligrams or more may actually be sleep promoting. Even though it's the same drug. Compound. Same compound. So you get what's called a dose dependent response.

And it's bimodal, meaning that it's the Goldilocks phenomenon, you know, not too little, not too much, just the right amount. And let's then entertain that you and I sit here in another five years time. There's been lots of work on this. And CBD now is a sleep aid. at the right dose. The question then is, how is it doing that?

And it's bimodal, meaning that it's the Goldilocks phenomenon, you know, not too little, not too much, just the right amount. And let's then entertain that you and I sit here in another five years time. There's been lots of work on this. And CBD now is a sleep aid. at the right dose. The question then is, how is it doing that?

And it's bimodal, meaning that it's the Goldilocks phenomenon, you know, not too little, not too much, just the right amount. And let's then entertain that you and I sit here in another five years time. There's been lots of work on this. And CBD now is a sleep aid. at the right dose. The question then is, how is it doing that?

Because for me as a scientist to entertain its causality, I at least want to understand mechanistically what it's doing to be a plausible parsimonious explanation. For CBD, I think it's actually at least two different routes. Like melatonin, CBD is really quite hypothermic. It will get rats cold when we dose them.

Because for me as a scientist to entertain its causality, I at least want to understand mechanistically what it's doing to be a plausible parsimonious explanation. For CBD, I think it's actually at least two different routes. Like melatonin, CBD is really quite hypothermic. It will get rats cold when we dose them.

Because for me as a scientist to entertain its causality, I at least want to understand mechanistically what it's doing to be a plausible parsimonious explanation. For CBD, I think it's actually at least two different routes. Like melatonin, CBD is really quite hypothermic. It will get rats cold when we dose them.

The colder their core body temperature, the faster sleep will arrive with them, the deeper the sleep that comes after. The second, however, I think is an indirect mechanism. I think now there is very good data, even human brain imaging data, that CBD is what we call anxiolytic, which it reduces down your anxiety. It takes you out of that fight or flight branch that we've been talking about.

The colder their core body temperature, the faster sleep will arrive with them, the deeper the sleep that comes after. The second, however, I think is an indirect mechanism. I think now there is very good data, even human brain imaging data, that CBD is what we call anxiolytic, which it reduces down your anxiety. It takes you out of that fight or flight branch that we've been talking about.

The colder their core body temperature, the faster sleep will arrive with them, the deeper the sleep that comes after. The second, however, I think is an indirect mechanism. I think now there is very good data, even human brain imaging data, that CBD is what we call anxiolytic, which it reduces down your anxiety. It takes you out of that fight or flight branch that we've been talking about.

It reduces cortisol levels. The emotional centers in the brain called the amygdala, they are turned down in terms of their volume of kind of cranked activation by way of CBD. So in other words, that kind of tired but wired phenomenon is potentially going to be medicated by CBD. CBD isn't necessarily generating sleep.

It reduces cortisol levels. The emotional centers in the brain called the amygdala, they are turned down in terms of their volume of kind of cranked activation by way of CBD. So in other words, that kind of tired but wired phenomenon is potentially going to be medicated by CBD. CBD isn't necessarily generating sleep.

It reduces cortisol levels. The emotional centers in the brain called the amygdala, they are turned down in terms of their volume of kind of cranked activation by way of CBD. So in other words, that kind of tired but wired phenomenon is potentially going to be medicated by CBD. CBD isn't necessarily generating sleep.

It's simply removing what is blocking your brain's natural ability to generate the sleep that it could do. If only it could try to reduce the anxiety that's getting in the way. And when I say anxiety here, I'm meaning the physiological, biological anxiety within the body. That's, I think, what CBD is potentially doing to get you into good sleep.