Dr. Michael Ormsbee

It was just simply looking at what was going on with lipolysis. And then we would measure oxidation with the breast samples as well. So you have to do both. But it gives you a better picture of exactly what's happening. So we finally had this tool to measure glycerol, so lipolysis, overnight. And I remember my doctoral student at the time Amber Kinsey was my first doc student running this study.

It was just simply looking at what was going on with lipolysis. And then we would measure oxidation with the breast samples as well. So you have to do both. But it gives you a better picture of exactly what's happening. So we finally had this tool to measure glycerol, so lipolysis, overnight. And I remember my doctoral student at the time Amber Kinsey was my first doc student running this study.

And I remember she came in and she's like, oh, my goodness, nothing happened. Like we didn't see any difference in lipolysis no matter if they took carbohydrate, protein, placebo, whatever we gave. And I thought we'd see something. And I remember going through the data and we're like, you know what this means? You can have something before bed and it does not change lipolysis.

And I remember she came in and she's like, oh, my goodness, nothing happened. Like we didn't see any difference in lipolysis no matter if they took carbohydrate, protein, placebo, whatever we gave. And I thought we'd see something. And I remember going through the data and we're like, you know what this means? You can have something before bed and it does not change lipolysis.

So you don't have to worry about the fat metabolism piece of this with a small, calorically small meal or protein shake and a protein dominant situation.

So you don't have to worry about the fat metabolism piece of this with a small, calorically small meal or protein shake and a protein dominant situation.

Yeah, and I agree. It's really hard in doing research in this space because... Everybody wants to find the magic pill or potion or situation. And there are very few studies where we find some kind of amazing claim that comes out of it. Almost every time we're saying, no, that didn't work. That didn't work either. That didn't work either. And it's really... It's a fun process to be on.

Yeah, and I agree. It's really hard in doing research in this space because... Everybody wants to find the magic pill or potion or situation. And there are very few studies where we find some kind of amazing claim that comes out of it. Almost every time we're saying, no, that didn't work. That didn't work either. That didn't work either. And it's really... It's a fun process to be on.

The beautiful thing is that that's equally as important in our field for people to know that. There are some fields where sort of, quote, negative data would be a big problem. But that's not the case here because it's really important people know if something works or doesn't and depending on what outcome you're looking at. Let me go back to a little bit of the pre-sleep protein story. So

The beautiful thing is that that's equally as important in our field for people to know that. There are some fields where sort of, quote, negative data would be a big problem. But that's not the case here because it's really important people know if something works or doesn't and depending on what outcome you're looking at. Let me go back to a little bit of the pre-sleep protein story. So

We were one of two labs doing this work from the early stages. So the other lab was Luke Van Loon's lab in Maastricht University. And their work is fantastic. Protein synthesis guy, big time. All protein synthesis.

We were one of two labs doing this work from the early stages. So the other lab was Luke Van Loon's lab in Maastricht University. And their work is fantastic. Protein synthesis guy, big time. All protein synthesis.

What Luke's group was doing was looking at pre-sleep feeding all from a muscle protein synthesis perspective, where we're looking at it more from a fat oxidation, fat mobilization, applied outcomes perspective. And so it was really fun. Several times I've teamed up with Luke to give talks at different conferences and things where we cover all aspects of this pre-sleep feeding.

What Luke's group was doing was looking at pre-sleep feeding all from a muscle protein synthesis perspective, where we're looking at it more from a fat oxidation, fat mobilization, applied outcomes perspective. And so it was really fun. Several times I've teamed up with Luke to give talks at different conferences and things where we cover all aspects of this pre-sleep feeding.

We probably do for a new one at some point. A lot of new data have come out. But for about 10 years, we were the only ones doing that work. Now it's like every week I find a new paper on the topic, which is really exciting. It's rapidly expanding our knowledge base.

We probably do for a new one at some point. A lot of new data have come out. But for about 10 years, we were the only ones doing that work. Now it's like every week I find a new paper on the topic, which is really exciting. It's rapidly expanding our knowledge base.

They prefer the muscle protein synthesis ones for sure. But it's really good work. And what Luke found out was that for a while we didn't even know if you – could have muscle protein synthesis at that period of time. No one had ever done it. So he was giving young men and older men protein boluses, and then they were doing lines and biopsies through the night and in the next morning and things.

They prefer the muscle protein synthesis ones for sure. But it's really good work. And what Luke found out was that for a while we didn't even know if you – could have muscle protein synthesis at that period of time. No one had ever done it. So he was giving young men and older men protein boluses, and then they were doing lines and biopsies through the night and in the next morning and things.

And one of those had like nasogastric feeding to get the protein in that way in these older individuals. So study after study after study showed, okay, yeah, you can feed at that point and have an increase in muscle protein synthesis. And their studies are awesome. And they did so much good work over the time. And so

And one of those had like nasogastric feeding to get the protein in that way in these older individuals. So study after study after study showed, okay, yeah, you can feed at that point and have an increase in muscle protein synthesis. And their studies are awesome. And they did so much good work over the time. And so