Dr. Michael Snyder

with the idea of building muscle mass, which failed miserably.

My glucose was gradually going up.

So I shifted to weight training.

I gained 10 pounds of muscle mass.

I do whole body MRI, 20 of them in the last eight or nine years.

And I basically did gain 10 pounds of muscle mass that had no effect on my glucose control.

And the reason for that was that I'm not muscle intolerant.

I'm a beta cell defect.

So I can gain as much muscle as I want.

It's not going to help me release

insulin from my pancreas.

So knowing your subphenotype is a big deal, but then I respond to certain drug, rapinolide, that actually promotes that release.

So knowing your subphenotype determines your drugs, but it also turns out this whole lifestyle thing I mentioned earlier is a big deal and coming back to some of the food stuff.

So we found that if you're...

basically insulin resistant, muscle insulin resistant, you will spike to potatoes and pasta, but not if you're insulin sensitive.

And if you have beta cell defect, you also spike to potatoes.

So you actually, you can sub-phenotype people according to what their glucose dysregulation is.

And that affects how you react to foods.

And so then the obvious thing to do is modify your eating behavior on those foods so that you can basically live a healthier life is the idea.

And so how are you going to subphenotype?