Dr Natalie Crawford

If I had to pick one right now, if it was available in the U.S., I think I would go with the esterotrol.

Option.

Okay.

And why?

Because it looks like so far it's newer that it has less of the downstream effects.

So you're not having that complete suppression, that complete binding.

And it may have and also probably has less risk of DVT, of blood clots.

Like we see it in postpartum depression.

It's very similar.

And in the perimenopause transition, we have a 40% increase in mental health changes.

And we know this because women tell us and we believe them.

But what's happening is that our neurotransmitters, especially GABA, serotonin, and dopamine levels are highly tied to what our hormone levels are doing.

Dysphoria.

But I was trained to give them an SSRI for those 7 to 10 days.

Yes, an antidepressant.

Only for those two weeks.

Seraphim, was that the brand name of it?

And it does tend to help.

But what no one taught me and what clinical experience has taught me and talking to all these other smart people is a low-dose estrogen.

Treating the root cause.