Dr Natalie Crawford

speaker

3,939 appearances 7 recordings 3 series first heard Nov 2024 last heard 12 Jun

Dr Natalie Crawford’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 6 in all, peaking in Jun 2026 with 2.

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unPAUSED with Dr. Mary Claire Haver · The Truth About Your Biological Clock: Egg Quality, AMH and Fertility with Dr. Natalie Crawford · 9 Jun 2026 podcast

You'll get hormonal changes of ovulation, but you won't have an egg released.

So that's really important because some women have middle schmertz, that middle pain.

Yeah, who say, I can feel myself ovulating because they feel that cyst bursting or they feel when the ovary's heavy from that bigger follicle.

And if you go take ibuprofen, when you feel that,

you can prevent that follicle from actually allowing the egg to be released.

So inflammation is important, but what's bad is the difference in chronic inflammation, right?

So when the immune system is constantly activated, then we see a shift in how your body's going to respond because it's not meant to be exposed to that chronic inflammation.

I explain it to patients as imagine there is a lever and we call this your inflammatory burden because inflammation is all around us.

We're not going to go down to zero.

But what we're trying to do is actively keep the lever as low as possible on any given day in the environment that we're in so that we have the resilience to respond to the night you get less sleep or the day that you do have a lot of stress or the crappy food you ate on the plane over.

So we want to be able to have response to tolerate these acute inflammatory moments.

But when you constantly have a burden that's up here, what starts to happen, it changes how your cells function in multiple ways.

So static interference on the radio, the brain gets really worried, it can't hear signals, starts to not send out the signals that it needs.

You also, chronic inflammation directly impacts the ovary profoundly.

So the ovary now can't respond to the signal that's coming in.

It also is going to damage the cells around the egg.

So now the egg can't make the hormones it needs to.

And it can get inside the egg and damage the chromosomes and the mitochondria.

And then to double down more, inflammation is one of the few things that can get into what I like to call the vault inside the ovary.

You know, you and I have the same favorite graph talking about how many eggs you're born with and how many exist when at birth and when you start puberty.

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