Dr. Nathan Bryan

And if that's prolonged, it leads to ischemic end organ damage and organ failure, and it can be deadly. So that's number one. And then number two is a condition called methemoglobinemia. And that's a big word, meaning that it oxidizes the iron of hemoglobin and reduces your oxygen-carrying capacity. So you'll become cyanotic. You'll get blue around the lips.

And if that's prolonged, it leads to ischemic end organ damage and organ failure, and it can be deadly. So that's number one. And then number two is a condition called methemoglobinemia. And that's a big word, meaning that it oxidizes the iron of hemoglobin and reduces your oxygen-carrying capacity. So you'll become cyanotic. You'll get blue around the lips.

Your extremities will turn white from lack of perfusion or lack of oxygen. But you never see that. I mean, you really never see clinical methemoglobinemia. Fortunately, your blood pressure will drop to an unsafe level long before you get any accumulation of methemoglobinemia.

Your extremities will turn white from lack of perfusion or lack of oxygen. But you never see that. I mean, you really never see clinical methemoglobinemia. Fortunately, your blood pressure will drop to an unsafe level long before you get any accumulation of methemoglobinemia.

Absolutely. So we understand at the DNA level, at the nuclear level, that nitric oxide is what's called a co-localizes with estrogen receptor to allow for the cell to turn on transcription and translation of the telomerase enzyme. So it's not only affecting the genetic transcription of that protein, but it's also regulating the function of the enzyme.

Absolutely. So we understand at the DNA level, at the nuclear level, that nitric oxide is what's called a co-localizes with estrogen receptor to allow for the cell to turn on transcription and translation of the telomerase enzyme. So it's not only affecting the genetic transcription of that protein, but it's also regulating the function of the enzyme.

So without nitric oxide, you have less telomere telomerase enzyme, and that telomerase enzyme isn't functional.

So without nitric oxide, you have less telomere telomerase enzyme, and that telomerase enzyme isn't functional.

So what happens with each cellular division, those telomeres can get shorter.

So what happens with each cellular division, those telomeres can get shorter.

Right? But as long as that telomerase enzyme is active, it prevents the shortening of the very ends of the chromosome.

Right? But as long as that telomerase enzyme is active, it prevents the shortening of the very ends of the chromosome.

Yeah, and different cell types have different replication rates, right? So the epithelium of the gut is highly regenerative, right? It's replicatable. We're replacing these cells all the time because it's the outside environment that you're having to continue to replace those cells. Neurons, to the exact opposite, aren't regenerative by nature. So we don't typically make them. I mean, we can.

Yeah, and different cell types have different replication rates, right? So the epithelium of the gut is highly regenerative, right? It's replicatable. We're replacing these cells all the time because it's the outside environment that you're having to continue to replace those cells. Neurons, to the exact opposite, aren't regenerative by nature. So we don't typically make them. I mean, we can.

It was once thought that you can't regenerate neurons, but today we know we can't. But yeah, so it affects different organ systems differently. But the data are clear, shorter telomeres, shorter lifespan.

It was once thought that you can't regenerate neurons, but today we know we can't. But yeah, so it affects different organ systems differently. But the data are clear, shorter telomeres, shorter lifespan.

Yeah.

Yeah.

No doubt. I mean, this is probably 20-year-old science where we find that, you know, probably 20 years ago, the microbiome project was complete. And what that means is that the bacteria that live in and on our body were completely mapped out. And these communities were identified in the gut, started in the gut, the gastrointestinal tract. And then, you know, you can culture the skin flora.

No doubt. I mean, this is probably 20-year-old science where we find that, you know, probably 20 years ago, the microbiome project was complete. And what that means is that the bacteria that live in and on our body were completely mapped out. And these communities were identified in the gut, started in the gut, the gastrointestinal tract. And then, you know, you can culture the skin flora.