Dr. Nathan Bryan
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Podcast Appearances
But if we lose that fluidity, if we don't have enough cholesterol in there, or if we have these polyunsaturated fatty acids, these synthetic oils, it completely disrupts the fluidity, completely disrupts intracellular signaling. And we develop cellular dysfunction. And what is that? Well, insulin institutes or causes an intracellular signaling, right? We get insulin minus insulin receptors.
The inside of the cell gets the signal. Glut4 goes to the membrane, brings in glucose, and we clear it from the circulation. But what happens when insulin doesn't transduce that signal to bring in glucose because of lack of cholesterol, because of lack of the fluidity and the signaling aspects of seed oils, we develop insulin resistance and diabetes.
The inside of the cell gets the signal. Glut4 goes to the membrane, brings in glucose, and we clear it from the circulation. But what happens when insulin doesn't transduce that signal to bring in glucose because of lack of cholesterol, because of lack of the fluidity and the signaling aspects of seed oils, we develop insulin resistance and diabetes.
The inside of the cell gets the signal. Glut4 goes to the membrane, brings in glucose, and we clear it from the circulation. But what happens when insulin doesn't transduce that signal to bring in glucose because of lack of cholesterol, because of lack of the fluidity and the signaling aspects of seed oils, we develop insulin resistance and diabetes.
And the worst, the half-life of these is about 600 days. And a half-life means that in 600 days, half of the seed oils that you had incorporated in your cell membranes is gone. And in the sciences, we need at least five half-lives to completely clear over 99% of that. So you need 10 years. If you consume Cetol, it takes 10 years to remove that exposure from the incorporation of human cells.
And the worst, the half-life of these is about 600 days. And a half-life means that in 600 days, half of the seed oils that you had incorporated in your cell membranes is gone. And in the sciences, we need at least five half-lives to completely clear over 99% of that. So you need 10 years. If you consume Cetol, it takes 10 years to remove that exposure from the incorporation of human cells.
And the worst, the half-life of these is about 600 days. And a half-life means that in 600 days, half of the seed oils that you had incorporated in your cell membranes is gone. And in the sciences, we need at least five half-lives to completely clear over 99% of that. So you need 10 years. If you consume Cetol, it takes 10 years to remove that exposure from the incorporation of human cells.
So they provide zero benefit. And it's not just an acute injury. This is a chronic thing. This is what leads to chronic disease. When you lose the activity of the functional unit of life, which is the cell, you get sick, you can't perform, and your health becomes compromised.
So they provide zero benefit. And it's not just an acute injury. This is a chronic thing. This is what leads to chronic disease. When you lose the activity of the functional unit of life, which is the cell, you get sick, you can't perform, and your health becomes compromised.
So they provide zero benefit. And it's not just an acute injury. This is a chronic thing. This is what leads to chronic disease. When you lose the activity of the functional unit of life, which is the cell, you get sick, you can't perform, and your health becomes compromised.
Yeah. Because everything we know about cell signaling and signal transduction from the outside sensing to inside regulation, whether it's transcriptional, translational regulation of proteins and enzyme function, I mean, it all depends on the integrity of the cell membrane and how we can transduce that signal.
Yeah. Because everything we know about cell signaling and signal transduction from the outside sensing to inside regulation, whether it's transcriptional, translational regulation of proteins and enzyme function, I mean, it all depends on the integrity of the cell membrane and how we can transduce that signal.
Yeah. Because everything we know about cell signaling and signal transduction from the outside sensing to inside regulation, whether it's transcriptional, translational regulation of proteins and enzyme function, I mean, it all depends on the integrity of the cell membrane and how we can transduce that signal.
I don't think, not to kind of convincingly tell us that this is a problem. I mean, the standard of care is you look at a standard lipid panel, cholesterol, HDL, LDL, triglycerides. I mean, those really don't tell us anything. Total cholesterol, you know, the people who live the longest typically have cholesterol between 240 and 280 based on the Framingham data. Triglycerides are inflammatory.
I don't think, not to kind of convincingly tell us that this is a problem. I mean, the standard of care is you look at a standard lipid panel, cholesterol, HDL, LDL, triglycerides. I mean, those really don't tell us anything. Total cholesterol, you know, the people who live the longest typically have cholesterol between 240 and 280 based on the Framingham data. Triglycerides are inflammatory.
I don't think, not to kind of convincingly tell us that this is a problem. I mean, the standard of care is you look at a standard lipid panel, cholesterol, HDL, LDL, triglycerides. I mean, those really don't tell us anything. Total cholesterol, you know, the people who live the longest typically have cholesterol between 240 and 280 based on the Framingham data. Triglycerides are inflammatory.
We have to get our triglycerides less than 150. But if you do an advanced lipid panel and look at certain lipoprotein particles, the size, the number, and the amount of oxidized particles, that tells us really how inflamed the cell is and how inflamed that person is.
We have to get our triglycerides less than 150. But if you do an advanced lipid panel and look at certain lipoprotein particles, the size, the number, and the amount of oxidized particles, that tells us really how inflamed the cell is and how inflamed that person is.
We have to get our triglycerides less than 150. But if you do an advanced lipid panel and look at certain lipoprotein particles, the size, the number, and the amount of oxidized particles, that tells us really how inflamed the cell is and how inflamed that person is.
But you have to ask for that because if you just go to your primary care physician and they do a blood draw, they're just going to give you a standard lipid panel, which to me doesn't provide any – it certainly has no prognostic value. You've got to dig a little bit deeper.