Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
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What is nitric oxide and why is it considered a miracle molecule?
Dr. Nathan Bryan, welcome back to the podcast. We have you here today to talk about the holy grail of health, nitric oxide, and the miracle molecule, as you like to call it. And specifically, we're going to start off today's episode by tier ranking the root causes of visceral fat, inflammation, and disease relating to poor nitric oxide production. Are you game for that? Let's do it. OK, so we're going to start off with a big one that my audience has questions on, which is alcohol. What's the relationship between alcohol and nitric oxide and where does it fall on our tier ranking system?
Well, I think it's, you know, it's certainly moderate alcohol consumption has some cytoprotective, cardioprotective properties. And so what happens is when you have moderate alcohol consumption, and we're talking maybe one or two drinks every couple of days, right? What that does is it's called alcohol or ethanol preconditioning. And this has been studied for 30 or 40 years. And the observation was that people who drink moderate alcohol, if they have a heart attack, the heart is a little bit protected from injury from someone who hasn't consumed alcohol. It's ethanol preconditioning. So it's upregulating an enzyme called aldehyde dehydrogenase, which is an enzyme that's responsible for metabolizing and prolonging nitric oxide activity. So there's a clear connection.
However, the problem with overdoing alcohol consumption, you get portal hypertension, you get liver disease, and it destroys nitric oxide production, leads to inflammation, oxidative stress, and immune dysfunction. I think what we're finding is, and the other thing people ask me all the time too, what about drinking alcohol and affecting the oral microbiome? Because we know alcohol-based mouthwash Kill it. But I tell people, at least when I drink a scotch, I'm not holding in my mouth for 30 or 60 seconds and swishing it around. So the alcohol in spirits in wine doesn't have a resident time long enough in the oral cavity to disrupt the microbiome.
So if you had to give alcohol a grade as it's related to not just nitric oxide, but the whole conversation of visceral fat inflammation. And again, to contextualize it, you're talking about a moderate light level of drinking, right? Where would you put it on our ranking here? All right, we have S is supreme. That means like something is really actually genuinely great for you. And then we have the classic grades, A, B, C, D, F. Where are we going to put alcohol on this tier rank system?
You know, if we're talking about moderate consumption and not over consumption, again, and this is not my opinion, it's based on published science. But I think it's somewhere in the middle. It's probably a D. I'll give it a D. Can you give it a D?
Yeah. Okay.
It's not extremely beneficial. I mean, there are other ways that lead to cytoprotection, cardioprotection that are probably more health-promoting than alcohol consumption. But it's certainly not an F.
Okay. We're going to come back to alcohol. I have a few more questions about alcohol and I want to talk to you a little bit about why I chose to stop drinking, but we have a few of the things to cover before we get into it. Just give us a little reminder. You know, you have a new book out and we've had you on the podcast before to talk about this, but your new book is called the secret of nitric oxide. Remind our audience why nitric oxide is truly one of the Holy grails when it comes to our health.
Well, we've known, we've learned over the past 40 years in this entire science of nitric oxide over 200,000 scientific papers published in the scientific and medical literature. So nitric oxide controls important things like blood pressure, sexual function, cognitive function. It controls inflammation, oxidative stress, and immune dysfunction, the hallmarks of chronic disease. It's involved in insulin signaling and glucose uptake. So we know today that the functional loss of nitric oxide inside the human body is the earliest event in the onset progression of most, I think probably all, age-related chronic disease. So if you're doing things that are disrupting nitric oxide production, that sets the stage for rapid acceleration, onset and progression of chronic disease.
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Chapters
5 chapters
1
What is nitric oxide and why is it considered a miracle molecule?
0:00–6:32
2
How does alcohol consumption affect nitric oxide levels?
6:32–1:03:43
3
What are the dangers of smoking and its impact on nitric oxide?
1:03:43–1:32:28
4
What role do ultra-processed foods play in nitric oxide levels?
29:26–1:32:28
5
How does hydration affect nitric oxide levels?
31:18–1:32:28
Speakers
3 identifiedMore from Dhru Purohit Show
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