Dr. Nathan Bryan
Appearances
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, I look, you make a great point. It's individualized. And if you eat something and you don't feel great afterwards, that's your body telling you, Hey, back off. And you said that people eat and they get flu like symptoms. I mean, that would tell me, and I tell people all the time, keep a food diary.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And if you're if you're struggling with health issues, anything you put in and on your body, write it down. And then a pattern will start to develop and then just kind of record how you feel. Then when you go back to that and you go, I felt horrible yesterday afternoon. Then you go back and say, oh, 90 minutes before that, I had McDonald's, Big Mac and fries and a 48 ounce Diet Coke.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I mean, you should feel better.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, look, processed foods, it's a broad category.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So processed, even things like ground beef, ground turkey, ground chicken. It's processed. Whey protein. Yeah, it's all processed. But the problem is, and there's this term you hear all the time, non-perishable food items. That's an oxymoron. If it's non-perishable, it's not food, right? Food is designed to have a certain shelf life.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so if you've got food that can sit on the shelf and not spoil... for weeks months years that's not food and the reason it's not food is because it's ultra processed and there's preservatives in there and things that won't allow it to rot or spoil and i think we've all seen this people who bought you know big mac and fries from mcdonald's that's been sitting outside
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
for 10, 12 years, it still looks like a Big Mac or fries that you would go and get if you bought it immediately.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It hasn't broken down. I mean, that is not food. And why is it not food? Because it's ultra-processed. So I think, again, the ultra-processed foods provide very little nutrient value. So there's no benefit. And what's the risk? The risk is all those preservatives that you're consuming are now disrupting normal cell biology.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So again, in the spectrum of risk benefit, ultra processed foods, again, I'd probably give it, you know, probably an E or an F. Okay.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Let's do a D. Okay.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Nitric oxide affects many different things. It turns genes on. I was here this week at a nitric oxide scientific meeting. The top probably 140 scientists in the world come together every two years and we discuss the latest in nitric oxide chemistry, biology, and the clinical applications of that.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But we're learning that nitric oxide can turn genes on and turn genes off by histone modification, by affecting DNA methylation. So it's really controlling the epigenetic regulation of gene expression. So there's many things that affect that. But here's what we know in terms of fat deposition. So it's the quality of the calories that we consume, and it's how we burn calories.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And it's based on the TCA Krebs cycle, glycolysis, and things like that. How do we mobilize fuel? So there's not a lot of data really on the direct effects of nitric oxide on fat metabolism. We know that through turning yellow fat to brown fat or white fat to brown fat, it's the yellow visceral fat that's inflammatory.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The brown fat is more thermogenic because it contains more mitochondria, generating more energy. So we know that things like caloric restriction, intermittent fasting, the cold plunge, the contrast therapy, all that has been known to convert the yellow fat, the visceral fat into brown fat, more thermogenic, and you basically consume more fat or burn more fat.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I'm not a fan of it. I do it. It's not very fun. But no, usually when I'm at home every day, I start my day in a sauna, 170 degrees for 30 minutes. And then I do a three minute cold plunge at 37 degrees.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We know that nitric oxide can help the body restore and replace cells during sleep. And so aging is just wearing ourselves out and the inability to repair and replace dysfunctional cells or senescent cells. And we repair and replace when we sleep.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So if you're not getting good sleep or if you have obstructive sleep apnea or you're hypoxic when you sleep, you can't produce nitric oxide, you can't mobilize stem cells, and you don't repair and replace dysfunctional cells. So in terms of poor sleep on nitric oxide, there are many other things that are affecting nitric oxide production than poor sleep.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But poor sleep will certainly lead to a loss of nitric oxide production because if you're not fully oxygenated, if you're not mobilizing stem cells and repairing and replacing cells that can work properly, then you can't make nitric oxide. And you're chronically inflamed, you're stressed, and it's just a downward spiral.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You know, if we're talking about moderate consumption and not over consumption, again, and this is not my opinion, it's based on published science. But I think it's somewhere in the middle. It's probably a D. I'll give it a D. Can you give it a D?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So today we know there's two ways that the human body makes it. One is through an enzyme called nitric oxide synthase. This enzyme is first found in our endothelial cells, the cells that line all blood vessels throughout the body. And so we call that ENOS. It's found in the neurons. We call it ENOS. It's found in our immune cells and activated macrophages. We call that inducible nitric oxide.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But really nitric oxide, the enzyme is found in most cells because every cell, part of that insulin signal transduction involves nitric oxide. So when that enzyme becomes dysfunctional, and it becomes what we call uncoupled, then it loses its ability to convert arginine, L-arginine, to nitric oxide. So that's number one. Number two is through the oral microbiome.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's not extremely beneficial. I mean, there are other ways that lead to cytoprotection, cardioprotection that are probably more health-promoting than alcohol consumption. But it's certainly not an F.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So the foods we eat, and I'm sure we'll address that, that are enriched in nitrate, the bacteria in and on the body convert that into nitrite and nitric oxide. So that obviously is dependent upon our diet. It's dependent upon the oral microbiome, and it's dependent upon stomach acid production. Any of those steps become compromised, and we lose the ability to make nitric oxide.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So one can compensate for the other. If we have poor endothelial function, if we eat a certain diet, we support the microbiome, and we have stomach acid, you can kind of compensate, if you will, for the lack of endothelial function.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But if you have endothelial dysfunction, a poor diet, and that's what most Americans are faced with, we see poor health, metabolic disease, hypertension, sexual dysfunction, cognition decline, and eventually Alzheimer's.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So just by way of clarification, we're ranking it based on overall health or overall nitric oxide production.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So these may be really bad for you, but it may be completely independent of nitric oxide production. Okay. So there may be a disconnect there. Okay, okay. Poor sleep is probably the worst thing. It would certainly be an F. But is it because it's disrupting nitric oxide production? If that were the case, then I would have to rank it probably midway, kind of halfway in between.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But certainly, poor sleep is a driver of chronic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, so stress is one of these subjective things that you ask, right? But for stress, for me, there's a stress response. There's stress hormones. There's overproduction of cortical. There's overactivation of the sympathetic nervous system and dysautonomia. And so what we have to do is correct that stress response. And so, but this is, you know, this takes...
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
a mental kind of a complete change in perspective. You know, everybody's stressed. We live in a stressful world, but stress doesn't solve anything. And I made a conscious decision many years ago that if I can't change it or control it, then I don't worry about it. And think about that. If you can't change the situation or control the situation, you shouldn't worry about it.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
That's 99% of the things that people stress over. Right. So what I do is it's, and it's still saying, it's not what happens to you that matters. It's how you respond to what happens to you that matters. So, You know, I live a pretty stress-free life.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
People apply a lot of stress to me. I just don't stress over it because if I can't control it or change it, what good does it do? It's not going to change the situation. No, but what we have to do is affect the, you know, there's something called adrenal fatigue and the adrenal glands secrete these things like adrenaline, these stress hormones and cortisol.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So when you have an elevation, chronic elevation of cortisol, I mean, that's a normal stress response. We need that acutely. But when you're chronically stressed, then it completely shuts down and disturbs other hormones and the whole endocrine system.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And it'll eventually shut down nitric oxide production because you're inflamed, you develop oxidative stress, and you develop an immune dysfunction.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, we call that hormesis in terms of how the body adapts to, because when we exercise or when we go for a run or when we do a cold plunge, it's an acute stress on the body. So the body then transduces an adaptive response. So like resistance training, there's intermittent hypoxia when we contract our muscles. It's squeezing on the blood supply. and then it's causing intermittent hypoxia.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So the body responds with angiogenesis. We're creating more blood vessels. So now with that same resistance, we're not developing hypoxia because now we revascularize that tissue. We develop, you know, we build more protein, we build more muscle, and that's, you know, the benefits of weight training.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
For instance, when we run, you know, if you're doing a marathon and you're running for two to three hours, you're completely diverting blood flow away from the kidneys, the intestines, and some people can develop ischemic organ disease. But the body adapts to that and go, oh, I don't want to run out of oxygen again. I need more mitochondria. Turns on mitochondrial biogenesis.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It improves the oxygen utilization. So now that cell can make more energy with less oxygen. And why is that? Because it was confronted, it dealt with a stress, an acute stress. And that's kind of like the cold plunge. When I go from the sauna, 170 degrees to 37 degrees, it's flexing the blood vessels. Because when you're hot in a sauna, your blood vessels are maximally dilated.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, we've known, we've learned over the past 40 years in this entire science of nitric oxide over 200,000 scientific papers published in the scientific and medical literature. So nitric oxide controls important things like blood pressure, sexual function, cognitive function. It controls inflammation, oxidative stress, and immune dysfunction, the hallmarks of chronic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
trying to rid the body of the heat so it doesn't overheat. Then when you go to cold, the body's trying to preserve heat so it constricts all the blood vessels. But for me, it's like weight training for your blood vessels because there's smooth muscle that's around all the blood vessels and it's working them out. But it's stressful. But the adaptive effects to that acute stress
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, we have to move. I mean, humans are designed to be mobile, to move. And yet most Americans aren't. We get in our car, we drive to work, we sit for six, eight, ten hours a day. Nobody gets exercise. And then the calories we consume through diet are stored as fat and become unhealthy.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But we have to move and kind of scientifically explaining this because exercise has been shown to stimulate nitric oxide production. And that's why exercise is medicine. You're giving your body activation and stimulation of nitric oxide. The other thing is kind of an electrical, you know, we're electrical beings, right? We diagnose death through loss of electrical activity, EEG or EKG.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So we have to maintain electrical conductance and flow and current and maintain voltage across cell membranes. Muscles are what we call piezoelectric, meaning that when we contract muscles and we move muscle, they're muscle battery packs. So they're creating voltage. And through the fascia, through these meridians, those muscle battery packs supply different organs with certain voltage.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So you'll find in one study, conductors who do this, you know, orchestra conductors, they have some of the lowest rates of heart attack and cardiovascular disease than any other profession. And why is that? Because they're doing this and this is fueling the muscle battery pack that supplies the heart. So that heart never runs out of voltage, never conductance.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And if you do that all over, we have to contract our muscles and get those battery packs. So when we lose voltage, When we lose this transmembrane potential, which is about minus 25 millivolts, and if you convert that to pH, it's a pH of 7.4, right, which is normal physiological pH.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
When we lose that transmembrane potential and we lose the ability for that cell to maintain some sort of negative inside with respect to outside of the cell, we develop dysfunction. And when the inside of the cell becomes positive with respect to the outside, we call that cancer. And that's, you know, the Warburg effect. So cancer only grows in a low oxygen, low pH, low voltage environment.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's involved in insulin signaling and glucose uptake. So we know today that the functional loss of nitric oxide inside the human body is the earliest event in the onset progression of most, I think probably all, age-related chronic disease. So if you're doing things that are disrupting nitric oxide production, that sets the stage for rapid acceleration, onset and progression of chronic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so when we move, when we exercise and we eat food and we ground and get electrons and we maintain some voltage and electron flow, then we become a little bit protective, not a little bit, we become a lot protective from chronic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Be sedentary and eat an ultra processed food diet, which unfortunately is most Americans.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
That's most people, yeah.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Look, there has to be benchmarks, right? You have to have something, kind of a milestone. I think it's not difficult at all to walk 3000 steps a day. So if you're not getting in 3000, then yeah, I think that's probably, if you're just walking from, you know, the couch to the toilet, to the kitchen, to the garage, from the parking lot to the, you should easily be able to get 3000 steps.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And if you're not doing that, then yeah, I think that would certainly be sedentary.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, that's right. The lymphatics, the lymphatic system is dependent upon muscle contraction, right? Especially in the lower extremities. If you're not moving them, you're going to get lymphedema. You're going to get pooling. And you're going to get neuropathy and, you know, vascular disease, peripheral vascular disease. So that's just one aspect. But you have to have a target.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You can't set goals if you don't have a target. So, yes, some of these numbers are random. Is it 3,000? Is it 10,000? It doesn't matter. But you have to have a target. You can never hit your target, hit your goal if you don't have a target. So I think it has some meaning. But what is the right target? Number? I don't know.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You can't do it one day and go, oh, I did that and then never do it again. You know, for me, I travel every week. And so sometimes I would, you know, when I when I arrive at a new hotel in a new city or new country, always go to the gym. Right. No matter what time of day it is, because I've been sedentary in an airplane for sometimes 15, 16, 18 hours.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And then when I figured out, you know, that's not always possible. So now what I do, and I've been doing this for probably six months, when I wake up, usually within five or ten minutes, I do 100 push-ups and 100 squats every morning. And that takes me less than five minutes. And I don't have to go to the gym anymore. And then I did that, and at first it was pretty difficult.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If we can maintain optimal nitric oxide production, both the basic science and the clinical science tells us that we can prevent or delay onset of age-related disease, cardiovascular disease, diabetes, vascular dementia, Alzheimer's. Everything we know about chronic disease revolves around poor blood flow, inflammation, oxidative stress, and immune dysfunction. And nitric oxide corrects all four.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But now I can get it in and no problem. So what I did, I'm not content with that. Now I'm doing 200. And I'll do that. When that becomes too easy, then I'll up it. But that, for me, I mean, I do an 18-hour fast every day. I wake up every morning, do 100 push-ups. Now it's 200 push-ups, 200 squats. And it just gets your day going. And it's mobilizing the lymph.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's removing a lot of the inflammation, the bags under the eyes, because everything's pumping. Blood's pumping, lymph is flowing, and you just feel better. There's no better way to start your day.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Now, just one short comment on firefighters. You know, firefighters in a general population have about the same risk of heart attack as any other profession. However, when they go into a burning building, their risk of heart attack within 24 or 48 hours after entering a burning building goes up tenfold.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because they're breathing carbon monoxide and all these toxins and pollutants. Particles 2.5, PM 2.5. And so they're at risk. And so we're, you know, certainly during the fires here in LA, we donate a lot of product to them to protect them. I mean, they're protecting the community and going in when... you know, doing their job and it's putting them at risk.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, yeah. I don't think, again, there's no benefit to not doing exercise. Yeah. And there's enormous risk. So, again, if we're using that same risk-benefit quotient, yeah, it's got to be at the bottom.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, again, I think it's individualized. It depends upon your metabolic flexibility. You know, continuous glucose monitors are available anywhere. Anybody should do it. And I think everybody should do the experiment. So broadly speaking, nightly dessert is not good. The worst thing you want to do is eat right before bed, and especially get a spike in blood sugar and insulin before bed.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You're not going to sleep well, and it's just going to, it's a recipe for disaster.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah. Now look, what you do one day a week is going to kill you. It's what you do the other six days. It probably will. So an occasional nightly dessert is not great, but as long as you're not doing that every night. And again, for me personally, I speak to what I do. I try to eat my last meal before 6 PM and then I don't eat again until noon the next day. So it's an 18 hour fast every day.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But, you know, they're not like at this conference. We eat at like 7 o'clock and there's always dessert. You're hanging around, you're networking, you're having a friendly conversation. And so, yeah, I'll have a bite or two or some cake or a cookie or something that's around. Does it affect my sleep?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, because I know I'm not going to get this spike in blood sugar because my insulin is very sensitive. My body can mobilize that and then bring it into the cell and I don't get the hyperglycemic response. And I certainly don't get an increase in heart rate. But everybody's different. So what I tell people is get your continuous glucose monitor and then figure out what you eat.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Again, take a food diary and figure out how big did that lead to an increase in blood glucose and how long did that persist. And then you have to experiment with yourself. And if you're concerned about the health is our number one asset. And if you're concerned about that, don't take my word because what I do may not work for you. You may not have the discipline to do what I do. Yeah.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Somebody else does that, you know, like the Ben Greenfields and the Dave Asprey support. I don't do what they do. It works for them, but it doesn't work for me.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You know, smoking with all the data, all the warning signs, even on the cigarette packages themselves, yet people still smoke. And I get it. It's an addiction. They know it's bad for them, but they get pleasure out of it. But smoking is absolute at the bottom. It's probably the worst thing you could do.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Now, look, it's improving your metabolic flexibility and improving insulin sensitivity. Because people monitor fasting glucose levels. And glucose is bad because it sticks to proteins and renders things dysfunctional. But the inflammation that occurs from that is due to the hyperinsulinemia, the elevation of insulin for prolonged periods of time.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so if you can improve insulin sensitivity, and that's where muscle mass comes in, because there's three main kind of cell types that take up glucose and are insulin sensitive. It's skeletal muscle, it's the liver cells, and it's the fat tissue. So if you increase in your skeletal muscle, then you're increasing insulin sensitivity, increasing glucose uptake.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And people who don't have a lot of muscle mass, then they're relying on the liver. It overburdens the liver, the fat cells, the adipose cells. And so you're working at 67% instead of 100%.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, the chronic hyperglycemia. And you monitor this through hemoglobin A1C. And what is that? That's sugar that's stuck to hemoglobin, the blood cell that carries oxygen to all cells in the body. But it's not unique to hemoglobin. It sticks to other proteins. It sticks to enzymes like nitric oxide synthase.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And in enzymology, these proteins have to be flexible and nimble and undergo conformational change to transfer electrons. If you got too much sugar and the sugar stuck to it, it's kind of, it's glue, right? If you spill a soda on the countertop and you come back the next day, what is it? It's sticky. That's glue. It's glucose. It's sugar. Sucrose in that case.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So it does the same thing in the body. Everything sticks together and then you can't, you know, red blood cells can't form. You can't deliver oxygen. develop, you know, coach your neurons, you develop neuropathy. It's just bad news. You have to eliminate sugar.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Interestingly, though, cigarette smoke, people who are smoking, we can detect nitric oxide gas coming off the burning cigarette. And we actually did, when I was in Boston, I believe we had a grant looking at the effects of nitric oxide and cigarette smoke on cardiovascular health.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Certainly at the bottom, it's probably not as bad as smoking or seed oils, but it's certainly not good. I mean, again, it's risk benefit. Are there nutrients in that? There's probably not a lot of healthy protein, probably not a healthy fats. There's a lot of carbs. It's going to disrupt your sleep. It's going to disrupt your sleep. So what do you think, a D?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, probably an E, yeah, D. Okay, great. We'll put that as a D.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I don't eat breakfast, but I know people who do. If you're going to eat breakfast, a high-protein, quality-fat breakfast is the best. The worst thing you can do for breakfast is eat pancakes and drink milk and things like that. Bacon, it's high-quality protein. It's good fat. And so if you're going to break your fast, then bacon is the way to go. Okay, you like bacon. I like bacon.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, but it's probably not promoting nitric oxide. So separate from nitric oxide. Okay. Yeah, bacon for breakfast. I think an intermittent fast every day and not breaking your fast in the morning is kind of the best prescription. But if you're going to eat breakfast, bacon for breakfast would probably be a B. Okay, great.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Me too. That's my preference.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So I think what we figured out was there's so many toxic things in cigarette smoke that it certainly outweighs the small benefit you may get from the little bit of nitric oxide that's found in cigarette smoke.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, I agree. But not a high carb breakfast. If you, if you have good metabolic flexibility, the body is designed to maintain optimal blood sugar. We need glucose. We need sugar to fuel cells, especially in the brain. That's a primary energy source for the brain is glucose. If you fast, the body then starts to break down glycogen stores primarily in the muscle and mobilize that as glucose.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So even if you're not consuming it, your body is making it through glycolysis and the breakdown of glycogen. So that's how our body maintains homeostasis.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But if you're not and you don't have a lot of glycogen stores, which a lot of people don't, you can do that through some impedance and figure out then you're going to get some low blood sugar and maybe feel lightheaded and dizziness and develop a little syncope and feel bad. Then I would recommend you probably have to eat. But again, it's the individual. It's the personalization.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Of medicine and nutrition.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, I think it's probably one of the worst things you can do. And again, it's not based on opinion. It's based on data, both clinical observational data and then understanding the mechanism of what that does. And so I, you know, I kind of compare it to the chronic use of antibiotics. No matter what physician you go to, here in the U.S.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
or abroad, there was no physician in his right mind that would say, I'm going to give you an antibiotic, and I want you to take this every day, sometimes twice a day, for the rest of your life. Why wouldn't they do that? Because today we know that destroying the microbiome, the bacteria that live in and on our body, causes systemic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The bacteria that live in and on our body outnumber human cells 10 to 1. And sure, there's some infectious pathogenic bacteria that cause disease, that cause infections. But for the most part, if we can maintain a healthy microbiome, then those bacteria kind of police the bad guys and keep them at bay.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So mouthwash destroys the microbiome, shuts down nitric oxide production because it's killing these nitric oxide producing bacteria. And then what are the consequences of that? We see an increase in blood pressure, which is the number one risk factor for cardiovascular disease, number one killer of men and women worldwide. You lose the protective benefits of exercise. And that's just a short list.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You develop sexual dysfunction because if you can't make nitric oxide, can't dilate blood vessels, can't get an erection. And so that's a major problem. And all you have to do is look at the numbers. Two out of three Americans use mouthwash every day, sometimes twice a day. Two out of three Americans have an unsafe elevation in blood pressure.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And prescription medication isn't bringing it down because there's no prescription antihypertensive medication that's targeted toward the oral microbiome. Antiseptic mouthwash, fluoride is absolutely one of the worst things you can do for the microbiome, nitric oxide production, and overall health.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So it's certainly an F. I mean, it's definitely an F. So we're going to put seed oils as an F. So we're talking about daily chronic antiseptic use. So just like if I get a scrape or something, it's infected and I have systemic inflection or at risk of developing sepsis. I want an antibiotic. Don't deny me an antibiotic, right? It's effective treatment for infections.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If you've got dental patients who have horrible, poor oral hygiene and really pathogenic bacterial infections that could cause them to have a heart attack or stroke or increase vascular inflammation, those patients may need an acute antiseptic kind of treatment, whether it's chlorhexidine or something to kind of eradicate, but you can't do it every day, right?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Just like you can't take an antibiotic every day because of the complete destruction of So we have to, and medicine is risk management, do what's best to get out of the acute critical phase. But then you've got to support the microbiome. You've got to support the body in eliminating daily chronic antiseptic use, whether it's antibiotic, fluoride, or antiseptic mouthwash.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You've got to get rid of it.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Why does poop stink? Why do your armpits stink? Why do some people stink? Why does your breath stink? It's bacteria. It's dysbiosis. So if you can maintain a healthy microbiome, you're not going to have bad breath. Your pits aren't going to stink.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so what we've done, and we've been working on this for probably six years, trying to figure out, I know in dental medicine, you have to eradicate the oral pathogens. But more importantly, we have to support the healthy microbiome. And that's why, you know, it took me five or six years to develop a toothpaste because what's the purpose of toothpaste?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Clean the teeth, clean the biofilms on the teeth, give the body the minerals it needs to enhance mineral density of the teeth, maintain healthy gums and normal pH, but more importantly, support the oral microbiome. And how do you do that?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, you create a toothpaste that's free of any kind of detergents, fluorides, antiseptics, but then create an environment after you brush your teeth that supports the repopulation of the healthy microbiome, improve the diversity of the microbiome, normalize the pH, and that's through our oral care products.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So we're developing a nitric oxide-friendly toothpaste and a nitric oxide-friendly mouth rinse.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You know, I was the person who developed these strips. Wow. In 2009, I developed these salivary test strips and created this kind of semi-quantitative colorimetric test strips. I filed patents on them when I was a professor at UT Medical School in Houston. Years later, we abandoned the patents because this chemistry that we're capturing on this test strip is old chemistry.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, they're nicotinic receptors inside the body. So nicotine is a vasoconstrictor. So when we have nicotine, it constricts the blood vessels. But there are many other kind of extravascular effects of activating the nicotinic receptors and the effects of nicotine. But it makes people feel good. I mean, it's an addictive substance. That's why people smoke.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's called the grease reaction. Grease. The grease. G-R-I-E-S-S. Okay. It was named after, I think, a chemist who developed that. It's a diazonium salt that forms that turns a pink color. So we can absorb it. We can detect it at 540 nanometers. So it should turn pink. And it's basically an acidified sulfanilamide reaction with nitrite.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Very complex chemistry, but it creates this colorimetric reaction that we can quantify. The reason that I abandoned the patents and the reason that I don't rely on them anymore is because there's false positives. So there's really no false negative. And really at the end of the day, when people understand what we're measuring and what it means, then I think they can provide value.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But people would use this test strip and think, oh, this is nitric oxide test strip. It's not a nitric oxide test strip. Nitric oxide is a gas. Once it's produced, it's gone in less than a second. What we're measuring here is salivary nitrite and the ability of the oral microbiome to recycle nitrate from the diet into nitrite. Then we swallow the nitrite in our saliva.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We get nitric oxide in the stomach. And the example came years ago, probably 10 or 12 years ago. We were demoing these test strips, I think, at a compounding pharmacy in Austin. And this 50-year-old guy walked in, severe obese, morbidly obese. His blood pressure was through the roof. He was diabetic. He hadn't had an erection in 10 years.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And obviously the clinical symptoms of nitric oxide deficiency, complete nitric oxide deficiency. He goes, oh, well, let me test this. He turns bright pink.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The higher the nitric oxide. The higher nitric oxide. The interpretation.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So we go, oh, he goes, I'm healthy. If what you're saying is true, I'm healthy. I don't need nitric oxide. Yeah. This dude had... all the comorbidities, all the symptoms.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
What we're measuring in that case is the immune reaction, the local immune response in the gingival tissue in the mouth from either an asymptomatic or even a symptomatic infection. He didn't even know he had an infection.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
but yet his immune system did, and it was creating, these macrophages were producing nitric oxide, it was spilling over in the saliva, and we were detecting it on these test strips.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, so what we're measuring is kind of steady-state salivary nitrite, and so this is dependent upon... Our diet, the last meal we had, the presence of oral microbiome, the activity of the receptors in the transport material in the duodenum, the silent receptor in the salivary glands. So it's a very complex cycle. It's called the enterosalivary circuit.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If it's intact and we eat a good diet, but again, it's based on our last meal, how dilute our saliva, people with dry mouth, poor salivary secretions. They're usually always low because they don't have that circuit intact.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The functional tests are much better. This is a biochemical test. Right, right. And I scored pretty high on that one.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
That's why people dip snuff or chew tobacco. And now you've got the nicotine in the vapes that are rampant. But again... Nicotine is one of these naturally occurring substances, and we have nicotinic receptors just like we have endocannabinoid receptors. So our body is used to seeing these things and initiating some signaling aspect.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So typically what I do is just get some saliva in your mouth. Get some saliva. And just apply it on the end of the test strip.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So this is, you'll see the pad there, the test pad.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So, you know, I haven't eaten since 5.30 PM yesterday. All right. Mine is like super light.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So mine, I mean, I'm optimal, but I work at this, right? I know my circuits intact. Yeah. And I got up this morning. I had one and a half cups of coffee. I did my 200 pushups, 200 setups. I activated, stimulated nitric oxide production. I have the right oral microbiome. And this is, this is typical for me.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, I think it's, you know, it's certainly moderate alcohol consumption has some cytoprotective, cardioprotective properties. And so what happens is when you have moderate alcohol consumption, and we're talking maybe one or two drinks every couple of days, right? What that does is it's called alcohol or ethanol preconditioning. And this has been studied for 30 or 40 years.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I think they have utility. I think they can be useful. But what I want and my goal and really going back to the book, writing the book is people need to understand what they're doing and what they're doing, what meaning that has. Same with these test strips. So I tell people it's a good tool to have in your toolbox.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But like Dr. Twyman, who's a good friend and a great cardiologist, he doesn't rely on this. He complements functional endothelial test, FMD, flow media dilatation, which looks at the functional production of nitric oxide in the lining of the blood vessels and then correlates it with a biochemical test. Then you really get a complete clinical picture. So the answer is they can have utility.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And we may bring them back because really what we're measuring is how well is your oral microbiome. And if you have a good diet and a good oral microbiome, then we can move the needle on these test strips. And that gives people something good because people want to see changes.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
A lot of times you don't feel the effects of nitric oxide, but you can certainly see it on these test strips in your fasting sugar, in your fasting insulin, in your blood pressure, in your sexual function. But people, it's a nice show and tell. For sure.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, I'll just show what we're doing. And the reason this is so important, and we may bring them back, is because the effects of toothpaste, daily oral hygienic practices have such a profound impact on the microbiome and nitric oxide production. But with this mouth rinse, we've recapitulated the effects of a healthy salivary pH environment. And so in these mouth rinses,
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We can actually, if you use it, I'm not a big fan of mouth rinse. I don't even, maybe I'll use my mouth rinse, but I don't need to. As I've shown you, I can do what I'm doing now, maintain healthy microbiome. I haven't had a cavity since I was five years old. I brush twice a day. I don't floss, but I eat a healthy diet and take care of myself.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But again, in the vapes, there's probably more toxic chemicals in there that outweigh the benefits of a little bit of nicotine.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So there's really no need for me to take my own mouth rinse. Well, maybe, maybe not. But people who don't, people who want to take a mouthwash and who want a fresh breath, they don't have a fresh breath otherwise, then this becomes extremely important. That could be helpful. It could be very helpful.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
N101.com. That's the letter N, the number one, the letter O, number one.com.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, so we'll launch it. We're going to launch it probably the third week of March, maybe the end of March. Oh, great. The toothpaste, the mouth rinse is probably maybe in April. But this CardioSmile, maybe Breath of Life, we call this Breath of Life because it's producing nitric oxide gas. But you can do a demo. So we saw that you didn't really light it, the test strip there.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But, you know, we can use this mouth rinse. Sure. And we'll just do a little demo here.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And now test strip. So obviously we've diluted the saliva a little bit, right? So maybe give it a couple seconds. But, you know, mine didn't. Mine was already pretty optimal. But what we're finding is that if what we've done with this mouth rinse, we can now start to see a complete change in the microbiome. Yeah. And what we're finding is kind of the same. The same.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So again, this takes time. Right. Because the turnover of these bacteria.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because the target for me was. Dysbiosis. In dental medicine, we need to still address the pathogens. The pathogens may be causing systemic disease. The oral pathogens causing systemic disease. We still need to address those. So how do we selectively kill the pathogens? But how do we restore and improve the diversity of the non-pathogenic commensal oral bacteria?
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
That's been the target, and that's what we've accomplished with this toothpaste and with the mouth rinse. That's exciting. All right.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Not a fan. No, personally, I wouldn't do it. I mean, anything that chronically constricts blood vessels to me is about chemists and physiologists and the biomedical sciences I stay away from.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The ones that I know that are probably the best clinically validated is a device called the Endopat. Endopat, sorry. Endopat, yeah.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So, and then there's others, you know, there's a CV profiler, there's the max pulse, all these, but they're all doing different things. The endopat is what we're looking, it's called flow mediated dilatation and it's venous occlusion plethysography is kind of the technique. But what that device does is, if you've done it, they put a blood pressure cuff on your brachial artery. Yep.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And then they pump it up to suprasystolic levels to where it's completely impeding blood flow.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, so for five minutes. So your fingers will tingle because there's no blood flow. Yeah. For five minutes. And then they release the cuff, and now you're getting this oxygen-starved tissue. It's now getting blood flow. The body's natural response is reactive hyperemia.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So the hypoxic, the low oxygen environment, when you release the cuff, if you have good endothelial function and the endothelial cells can make nitric oxide, it immediately dilates the blood vessels. It immediately produces nitric oxide and immediately dilates the blood vessels.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So in the endopat, I believe they're looking at change in temperature of the fingertip, which is correlated to how well, how fast the blood supply returns to that ischemic tissue.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Now that's the functional production of nitric oxide because nitric oxide is produced. It's gone in less than a second. It signals, it relaxes the smooth muscle, dilates the blood vessels. And that's the only way you can detect it. What we're doing here is kind of understanding the circuitry and the oxidative end products of nitric oxide and how the body handles it.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But then there's other machines that are non-ischemic or non-occlusive that's looking at the elasticity of the blood vessels or the compliance of the blood vessels. So with each beat of the heart, you know, the aorta is very important because it dampens that pulse response.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And the ability of the endothelial cells to produce nitric oxide to dampen that heartbeat and that pulse response predicts vascular health.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because if you have stiff arteries with each beat of the heart, that pulse wave travels really fast down the vascular tree. Then when it hits kind of the bifurcation at your renal arteries, that wave reflects. Now you've got a reflective wave going on that new heartbeat, and there's an overlap, and you can look at the waveform.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
on that and so that's the beauty of things like the cv profile or the max pulse because it's looking at the structure of the blood vessels if somebody's listening today and they're like well i want to find a practitioner that does these tests where do they go look there's not enough clinicians i mean the really good innovative physicians cardiologists like dr twyman mark houston the ones that are kind of on the cutting edge of diagnostics and clinical care
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You got to find them. But as we, and the beauty of this podcast is if patients go to their doctor and demand this and they start asking enough, then they'll almost be forced to bring it in the clinic. And there's no reason they should, because whether it's a cash practice or an insurance-based practice, there's ICD-10 codes for these diagnostics.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The data is only good if you know what to do with it and how to interpret it.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, I mean, sunlight is beneficial in many ways. Part of it is due to the release or activation of nitric oxide. So there's certain wavelengths of the sun, both infrared and both ultraviolet, so kind of both ends of the visible light spectrum. So infrared light coming from the sun or infrared light technology provides a frequency and a vibration that can release nitric oxide bound to metals.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So when nitric oxide is produced in the body, it's a gas, and typically it has an affinity for metals, and then it binds to that metal. And sometimes it can be released. If we dispose to certain frequencies like infrared light, it'll release that nitric oxide, and that becomes vasoactive. It can dilate blood vessels. The ultraviolet can actually bind.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
That energy is much higher, so it can cleave a nitric oxide molecule bound to a thiol, what we call a nitrosothiol. It's a much stronger bond, covalent bond. You need higher energy to release that. But, you know, as we know, it activates vitamin D, the active form of vitamin D. Worse than lack of sunlight is sunscreen.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because you've got the toxic chemicals in the sunscreen that's completely preventing... Traditional sunscreen. Traditional sunscreens. I stay away from it. My kids, none of us wear sunscreen. Very dangerous.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Look, it lowers blood pressure. If you look at just epidemiological data, people who live in kind of Scandinavia and northern kind of countries or societies have higher blood pressure on average than people who live near the equator. And there are a lot of confounding factors on that. But a predominant hypothesis or theory is that it's because there's less sunlight.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We know through the mechanism of nitric oxide production, we can produce nitric oxide. We can dilate blood vessels to normalize blood pressure.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
There's no benefit.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, I think it gets an A. Again, because it's moderate and it's dependent upon skin type. Yeah. You know, kind of the white, kind of the typical Irish American, you know, that has really light skin, light complexion. compared to a person who makes a lot of melatonin, African-Americans, dark skin. The requirements are completely different. Again, it's the personalization of diet and lifestyle.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Now, that ranks up there. That's pretty high. Would you put that as an S? Well, it depends upon... endogenous systems in the person that's exposed to that light.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But certainly it's the most cost effective and effective thing you can do if you want to do one thing, because it has multiple benefits. Number one, you're getting that 20, 30 minutes of sunlight and that first sunlight a day completely sets, resets your circadian rhythm, right? Because it's that for saying to you, Oh, it's daylight. It's time to wake up. We've been, have our eyes closed all night.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We've been in darkness. Now we're waking up and it completely sets our circadian rhythm.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because it's fueling at least one of the major pathways, how the body produces nitric oxide, right? So nitrate is found primarily in green leafy vegetables. Then when we consume it, About 90 minutes after we consume that food or that nitrate-rich vegetable, it's concentrated in our salivary glands. Now we're secreting nitrate with the saliva. We have the right bacteria. It's reducing this.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's doing a two-electron reduction of nitrate to nitrite. Now our saliva is enriched in nitrite, which we can detect with the test strips. And then we swallow our saliva. And that nitrite becomes nitric oxide gas in the lumen of the stomach as long as there's stomach acid production.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But if we're taking antacids, proton pump inhibitors, and there's no stomach acid secretion, we disrupt that entire cycle. And that's the other problem. You know, we may detect nitric oxide in the saliva, but if we're taking an antacid, you're not going to get the nitric oxide that's produced in the lumen of the stomach.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, maybe even worse. I mean, because they're causing death. I mean, the proton pump inhibitors are causing a 40% higher incidence of heart attack, stroke, and Alzheimer's. This is very clear, indisputable clinical observational data. Because they're shutting down nitric oxide production.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's leading to an elevation of asymmetric dimethylalarginine, which is then inhibiting the enzyme in the lining of the blood vessel from producing nitric oxide. So this one class of drug shuts down both pathways to produce nitric oxide in the body. And what do we see? Heart attack, stroke, and Alzheimer's.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
No, these are like similar to SSRIs and you can't just stop these drugs cold turkey because there's clinical consequences to that. You'll get an overproduction and secretion of stomach acid and life will be miserable.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
See, I told you you're dependent upon these, yeah. Yeah. Now, so what I, again, work with your prescribing physician, but the best kind of recipe I found is whatever dose you're taking, cut it in half. And now for 10 days, take that half dose. And then after 10 days, take that half dose every other day. And then do that for 10 days.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So we're slowly titrating down the circulating levels of these PPIs. And then once you get those 20 days, then you can stop. But then, because you need stomach acid to absorb things like B vitamins, iron, zinc, iodine, things you need to make stomach acid on your own, you have to supplement that because your body hasn't been able to absorb that.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I tell people, take apple cider vinegar before a meal. So now you're acidifying the lumen of the stomach. So now you can actually break down the foods you're eating so you don't get reflux. And you've got to figure out what nutrients you're missing.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If you've been on antacids, if you do a micronutrient analysis test, blood test, you're going to find that you're depleted in B vitamin, selenium, chromium, iron. You may be anemic. You don't have any iodine because all this requires stomach acid production.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You know, that's a great question, a question we've been trying to answer, but no, it doesn't appear to be. And here's the thing, when we list things like beets, and there are hundreds of beet products on the market now, which typically aren't providing nitric oxide. But the problem with root vegetables, the problem with green leafy vegetables is the oxalates and the oxalic acids.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So some people that are prone to developing kidney stones may not be able to tolerate things like this. But here's the deal with the straight carnivore diet is that you're not getting the inflammation from the high carbs. And you're not getting the sugar. So what we're doing is we're maintaining optimal endothelial function. That enzyme is functional.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So now we can make nitric oxide on demand in the lining of the blood vessel. And we're less dependent upon the oral microbiome in feeding this pathway through the diet. Because I think most carnivores, if you've made a decision, a conscious decision to eat a carnivore-based diet, at least in my interaction with the people I've met, these people are very health conscious.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
They're working out every day. They're getting sunlight. They're getting sunlight. They're drinking good, clean water. And they're doing everything else. So they can get away with that, of elimination of the nitrate. But here's the other thing. If you're making nitric oxide in the body, in the lining of the blood vessels— That nitric oxide is immediately oxidized to nitrate.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So now we have nitrate, an elevation of nitrate circulating in the blood, and it's taken up in the saliva, and we're still secreting nitrate. But the nitrate is not coming from the foods we eat. It's coming from the oxidation of nitric oxide that was produced in the lining of the blood vessel.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, look, the body is 80% water and the water hydrates cells that allows for the transport of minerals and oxygen and nutrients. And if we're dehydrated, you know, we become dehydrated at the cellular level, right? And so then we get a buildup of toxins. And so now you've got a lower volume and a higher concentration of toxins. It becomes toxic to the cell.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And hydration and urination is part of detoxification. So we drink water, we have an exchange of solutes, and we urinate it out. If we're dehydrated, obviously we make less urine because the body's trying to preserve what volume it has. So then we get a buildup of toxins.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But the problem is, you know, municipal water supply, which is toxic, you're hydrating, but you're actually poisoning yourself too. And that's why I recommend good clean water, good, you know, well-designed home filtration system, remove the fluorine, the fluoride, the chlorine, the chloramines, the drug metabolites that's found in municipal water.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But it's just a good way to detoxify, to dehydrate the cell or to hydrate the cell and to maintain good health.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I didn't realize I was focused on...
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Well, these are a class of drugs called NSAIDs, or non-steroidal anti-inflammatory drugs. You can get them over the counter. All we have to do is look at the history and the use of these. And the number three killer of men and women worldwide is medication. Prescription medication, over-the-counter medication. NSAIDs cause gastric bleeds that cause gastric ulcers.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Things like acetaminophen, which is Tylenol, can cause liver failure, liver disease, and death from liver failure. So these are very effective anti-inflammatory drugs. But what they're doing is they're masking the symptoms of inflammation without getting to the root cause of the inflammation. Same thing that steroids do. They kind of suppress the inflammatory response and alleviate pain.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But what they don't do is address the root cause of the inflammation. So if your diet is inflammatory, if your lifestyle is inflammatory, if you have infections that are inflammatory, the worst thing you should do is just take an anti-inflammatory drug. Get to the root cause of it because that inflammation is still there. You just don't feel it. And so, again, it's risk benefit.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Certainly, they can provide benefit on alleviating pain in chronically inflamed patients. But the risk, there's also risk there. There's nothing that's without risk. And so you just have to, again, it's personalized.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
It's the number one driver of chronic disease and it's the number one thing that completely shuts down nitric oxide production. It is the number one enemy. And it's a national security crisis, right? Because we don't even have enough healthy young kids these days to serve in the military. They can't even pass a physical. So this is a national security issue.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Years ago, 30 years ago, we knew that once you develop diabetes, get what's called advanced glycosylation end products, or AGES, and that's sugar that's stuck to enzymes, hemoglobin, other proteins like the nitric oxide synthase enzyme. completely shuts down nitric oxide production.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And that explained why diabetics have higher blood pressure, they have diabetic retinopathy, they have diabetic neuropathy, and everything that in rectal dysfunction, everything about diabetes shuts down nitric oxide production, explained everything about the clinical presentation of diabetes.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Then the other thing is we're learning now that once you get, if you lose the ability to produce nitric oxide from poor diet, from sedentary lifestyle, that leads to insulin resistance.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because as I mentioned earlier, when insulin binds to the insulin receptor, it activates intracellular signaling called AKT, PI3 kinase, and AMP kinase, which is the target of metformin, glucophage, the main anti-diabetic drug. And those two proteins, what we call kinases, activate the nitric oxide synthase enzyme. But in diabetics, we know that that enzyme isn't functional.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so it's a loss of signaling. It's resistant to insulin. We call that insulin resistance because the cell can't make nitric oxide to bring glucose into the cell. So now, if you develop insulin resistance, you've got a feed-forward mechanism. It's decreasing nitric oxide production, which is then decreasing insulin signaling.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Now you get hyperglycemia, hyperinsulinemia, and it's just fueling this diabetes. And it's uncontrolled. And now you see even type 1 early-onset diabetes that now become insulin-resistant to their own insulin that they're having to take. This is a huge problem. But it's the number one driver. And so we have to get to the root cause of this. We have to give nitric oxide.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If your body can't make it, then we got to get it. And that's what I've spent 25 years doing. Now we can improve insulin signaling, glucose uptake, restore endothelial function. And then you see, along with changing their diet and their lifestyle and the things that made them diabetic in the first place, we can correct them.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Because we know diabetes is reversible, it's curable, it's treatable, and it's preventable. Type 2 diabetes. Type 2 diabetes. So once you understand the mechanism of how insulin is secreted and insulin signals and glucose is taken up into the cell and we clear it from the circulation, then you can start to take steps to address that. And the other thing is Alzheimer's. It's diabetes type 3.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And it's going to increase sixfold in the next 10 to 15 years. And what is Alzheimer's? It's insulin resistance. Again, the brain uses glucose, so you can't get glucose into the cell. Those cells don't function. You get misfolding of proteins. There's focal ischemia, so loss of regulation of blood flow to the brain.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
You get neuroinflammation, you get oxidative stress, and you get immune dysfunction. That's Alzheimer's. What does nitric oxide do? It perfuses the brain, gets insulin in the cell, inhibits the inflammation, mitigates the oxidative stress, and prevents the immune dysfunction. So you don't get protein misfolding. I mean, it's the root cause. I mean, again, that's the purpose of writing this book.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So consumers and physicians and patients can begin to understand that maybe this one molecule, it's not a panacea, it's not a silver bullet, but understand your own health challenges. Consider nitric oxide may be the cause. The lack of it may be the cause of your health problems. But more importantly, it may be part of the solution.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And so just employing these things that we talk about today of diet, lifestyle, eliminating things that are inhibiting nitric oxide production, and focus on the restoration of this molecule, and your life is going to transform. I mean, I've been doing this for 20 years, and I get emails, texts every day when I wake up, hundreds of we've changed people's lives.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
There's just nothing more gratifying than that.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Or just reduce how much you're eating in a day.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
2,000 calories into 1,500.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah, all of our products are going to be the N101. It's our consumer product division of our drug company, Bryan Therapeutics. So my objective is to create safe and effective nitric oxide product technologies in every major market segment around the world. We've done it in supplements, our orally disintegrating tablet. We make a fermented beet powder for pre-workout and energy.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We've got a skincare line of products for skin and fine lines and wrinkles. Oral care, we've got a toothpaste and mouth rinse coming out, which I think is going to be a game changer. Because 50% of the people who have high blood pressure don't respond to prescription medication. And it's resistant hypertension.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And the reason they're resistant to drug therapy is because it's not affecting their, the hypertension is a symptom of oral dysbiosis. So what we're finding is if people change out their toothpaste to our toothpaste and then start using our mouth rinse, we can improve the oral microbiome and we watch their blood pressure come down. simply by targeting the oral microbiome.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And now, for the first time in the history of Western medicine, we can talk about how do we get people off medication. That's never happened before.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And we covered many of them. The body is smarter than we are. We just got to get out of the way, give the body what it needs and let the body do its job. And I think that's the direction we need to take.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
My objective is to educate, inform, you know, and I developed a YouTube channel, Dr. Nathan S. Bryan, Nitric Oxide. I'm on LinkedIn, Instagram, Dr. Nathan S. Bryan. Yeah, nathansbook.com. This will officially launch February 24th. Oh, beautiful. It's where books are sold. Amazon, Barnes & Noble, a thousand private booksellers around the U.S. And then for those interested in the products,
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And if your body can't make it, then we do it for you. And we got products that actually produce nitric oxide. In fact, I coined a term and trademarked nitroceuticals to differentiate what we do from all the other nitric oxide products out there. And those are at N101.com.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And the observation was that people who drink moderate alcohol, if they have a heart attack, the heart is a little bit protected from injury from someone who hasn't consumed alcohol. It's ethanol preconditioning. So it's upregulating an enzyme called aldehyde dehydrogenase, which is an enzyme that's responsible for metabolizing and prolonging nitric oxide activity. So there's a clear connection.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
If we had a Z on the ranking, I would rank it as Z. You'd put it as Z. But right now we're going to put it at F. It's the absolute bottom. And again, for me, it's about what are the risks and what are the benefits? Yeah. And there's really no benefit of seed holes. What are the risks? I mean, we probably don't have enough time on the show to talk about the risks.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But the same people who are saying the so-called experts and nutritionists and epidemiologists who tell us that, you know, seed oils provide some benefit are the same people who told us that cholesterol causes heart disease for the best 30, 40 years. And it's absolutely false. Cholesterol does not cause heart disease. Targeting cholesterol to mitigate or to prevent heart disease has failed.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
In fact, it's made people worse. Again, let's talk about what cell biology and the effect of seed oil on human health. So every cell in the human body has a phospholipid bilayer, a cell membrane. And the fluidity of that cell membrane allows for intracellular signaling.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So the cell senses an extracellular environment, and then it binds to receptors, and through this, really, it's a seven-transmembrane receptor signaling, and then it activates intracellular signaling, turns on proteins, turns on certain genes.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But if we lose that fluidity, if we don't have enough cholesterol in there, or if we have these polyunsaturated fatty acids, these synthetic oils, it completely disrupts the fluidity, completely disrupts intracellular signaling. And we develop cellular dysfunction. And what is that? Well, insulin institutes or causes an intracellular signaling, right? We get insulin minus insulin receptors.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
The inside of the cell gets the signal. Glut4 goes to the membrane, brings in glucose, and we clear it from the circulation. But what happens when insulin doesn't transduce that signal to bring in glucose because of lack of cholesterol, because of lack of the fluidity and the signaling aspects of seed oils, we develop insulin resistance and diabetes.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And the worst, the half-life of these is about 600 days. And a half-life means that in 600 days, half of the seed oils that you had incorporated in your cell membranes is gone. And in the sciences, we need at least five half-lives to completely clear over 99% of that. So you need 10 years. If you consume Cetol, it takes 10 years to remove that exposure from the incorporation of human cells.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
So they provide zero benefit. And it's not just an acute injury. This is a chronic thing. This is what leads to chronic disease. When you lose the activity of the functional unit of life, which is the cell, you get sick, you can't perform, and your health becomes compromised.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Yeah. Because everything we know about cell signaling and signal transduction from the outside sensing to inside regulation, whether it's transcriptional, translational regulation of proteins and enzyme function, I mean, it all depends on the integrity of the cell membrane and how we can transduce that signal.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
However, the problem with overdoing alcohol consumption, you get portal hypertension, you get liver disease, and it destroys nitric oxide production, leads to inflammation, oxidative stress, and immune dysfunction. I think what we're finding is, and the other thing people ask me all the time too, what about drinking alcohol and affecting the oral microbiome? Because we know alcohol-based mouthwash
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
I don't think, not to kind of convincingly tell us that this is a problem. I mean, the standard of care is you look at a standard lipid panel, cholesterol, HDL, LDL, triglycerides. I mean, those really don't tell us anything. Total cholesterol, you know, the people who live the longest typically have cholesterol between 240 and 280 based on the Framingham data. Triglycerides are inflammatory.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
We have to get our triglycerides less than 150. But if you do an advanced lipid panel and look at certain lipoprotein particles, the size, the number, and the amount of oxidized particles, that tells us really how inflamed the cell is and how inflamed that person is.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
But you have to ask for that because if you just go to your primary care physician and they do a blood draw, they're just going to give you a standard lipid panel, which to me doesn't provide any – it certainly has no prognostic value. You've got to dig a little bit deeper.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Certainly these C-dolls are inflammatory. So you'll see inflammatory markers, whether it's C-reactive protein. These are kind of lead to lipid peroxidation and inflammation within the cell membrane. So you may see ferritin go up. You may see uric acid go up, C-reactive protein. Those are kind of the acute phase inflammatory markers that you may see in people who are chronically consuming C-dolls.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
And they'll probably have metabolic disease.
Dhru Purohit Show
Having Low Levels of this Miracle Molecule Puts You At Risk of a Heart Attack. The Best and Worst Habits to Increase Nitric Oxide Production with Dr. Nathan Bryan
Kill it. But I tell people, at least when I drink a scotch, I'm not holding in my mouth for 30 or 60 seconds and swishing it around. So the alcohol in spirits in wine doesn't have a resident time long enough in the oral cavity to disrupt the microbiome.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I'm absolutely convinced this will eradicate and cure Alzheimer's. Really? The data don't lie. And I'm a data guy. And the future of medicine and healthcare around the globe is going to be dependent upon this. Dr. Nathan Bryan is the biochemist whose cutting-edge research suggests how one crucial molecule can impact our health, brain function, and longevity.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And again, through database of hundreds of thousands or millions of patients, you can figure out where you fall on that spectrum on endothelial function. And then there's other markers looking at histone modification of the DNA, methylation profiles. There's a company or a technology called GlyconAge that looks at certain markers that can then define a biological age for each individual.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yep. We've touched on them. So erectile dysfunction. 50% of the men over the age of 40 self-report erectile dysfunction. That's in the U.S. So think about that. 50% self-report. I think the numbers are higher because most 40-year-olds that I know are never going to admit that they have erectile dysfunction. So I think the numbers are even worse. So that's one. High blood pressure.
The Diary Of A CEO with Steven Bartlett
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Again, 50% of the patients that are treated with prescription medication don't respond with better blood pressure. That's a huge problem because high blood pressure is the number one driver of cardiovascular disease, which is the number one killer of men and women worldwide. Number three, metabolic disease and diabetes.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
We published in 2011 that nitric oxide production is necessary for insulin signaling. If the cell can't make nitric oxide, you develop insulin resistance. So diabetes, a global pandemic. Nine out of ten Americans are metabolically unfit. The other thing is exercise intolerance.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
If you try to start an exercise regimen and you can't walk up a flight of steps or exercise moderately for 15, 20, 30 minutes, then you're nitric oxide deficient. And then the other one is obviously Alzheimer's because Alzheimer's is a vascular disease. It's reduced blood flow to the brain, what we call focal ischemia. There's insulin resistance. Alzheimer's has been called diabetes type 3.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So you can't get glucose into the cell, and that's the primary energy source or substrate of the brain. Oxidative stress and immune dysfunction. And then you get misfolded proteins, and that shows up as the tau tangles and the amyloid plaque that we see in Alzheimer's patients. So if we can restore—and nitric oxide corrects every single thing we know about Alzheimer's.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
It improves blood flow to the brain. It improves glucose uptake, so it overcomes the metabolic aspect of Alzheimer's. It reduces inflammation. In fact, a number of my patents are on a method of reducing inflammation. It inhibits the oxidative stress we see in Alzheimer's and neurological disease, and it prevents the immune dysfunction.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And when you do that, when you restore blood flow and you get nutrients and oxygen in and you take out the metabolic waste products, there's no misfolding of protein. So you don't get the amyloid plaque. You don't get the tau tangles. So this simple molecule, nitric oxide gas, I'm absolutely convinced will eradicate and cure Alzheimer's.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Because it addresses every physiological root cause of Alzheimer's.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, I think that's a very key because the success or failure of any clinical trial, any drug in any clinical trial is dependent upon the design of the clinical trial and what patients at what stage of disease that you enroll these patients. So what are the inclusion criteria and what are the exclusion criteria?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And there's a stage in every disease, whether it's heart disease, kidney disease, Alzheimer's, where you've reached a point of no return. There's really no medical therapy that's going to reverse that disease because it's progressed to a state that's irreversible.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So I think what we try to do is take patients early in the process, what we call vascular dementia, mild cognitive impairment, early Alzheimer's. Because what I want to be able to demonstrate is two things. Number one, can we stop the progression of disease? Once it's started, can we stop the progression?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And then number two is we want to enroll patients far enough along to where we can show regression. So can you move the needle back? And so that's a very kind of a specific and finite patient population. When you design a clinical study, number one, at the absolute worst, we want to stop progression. At the absolute best, we want to show that we can regress disease.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And that's the goal of therapy, is that you understand the mechanism of disease to the extent that you can treat it, you can prevent it, you can reverse it, and you can cure it.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I believe in the truth, and I come from a very objective scientific background, so everything that we do is based on objective data.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, absolutely, because, you know, we talk about epiphanies and eureka moments in science. But for me, one of the kind of complete change in paradigm in the way that I think was changed when I was in academia and teaching in medical school and doing research in an academic institution. And you start to think, in the scientific community, we've cured every disease.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Every disease known to man, we've cured it in rats and mice. So then the question is, why isn't this translated into patient care? Why can't we do this in humans? Number one, in animal experiments, we control their environment. We control their food. We control their light cycle. We control everything about them. You can't do that. Everybody has a different diet.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Everybody has different drug therapy that they're on or hygienic practices. But then what I realized was because when I was in academia, we wanted to create this consortium, a center of excellence for diseases, because my thought process was, you know, Western medicine is siloed, right? If you have a heart problem, you go to a cardiologist.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
If you've got a GI problem, you go to a gastroenterologist. If you've got a neurological problem, you go to a neurologist or psychiatrist. But none of these disciplines talk to one another. So if you go to, that neurologist is going to treat that condition much different than the cardiologist would, much different than the GI doc would. But what if we're looking at the exact same root cause?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so my philosophy, well, let's create a center of excellence and let's bring everybody in the room. Let's bring the GI docs, the neurologist, the cardiologist, the geneticist, the pulmonary docs, the kidney docs, the renal docs. And let's understand this kind of wheel and cog because everything occurs at the mitochondria, subcellular level, and energy production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And then basically everything can manifest from that. But what I quickly realized when you go to, for instance, MD Anderson and trying to treat cancer, no one is interested in curing cancer. No one is interested in curing human disease. Because the epiphany for me came because medicine is a business. It's a for-profit business.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
In fact, it's the largest business and economic model in the world, trillion-dollar annualized market. And most of these drug companies who influence and pay and support scientific journals, JAMA, New England Journal of Medicine, the major publications, the major journals, and they're influencing regulation and policy and FDA.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so when you figure out that there's undue influence by these for-profit companies, because the number one rule of business, as you know as an entrepreneur and a business guy, is acquire a customer and keep that customer as long as you can. Call it lifetime value of that customer. And that's what medicine is. They get you, they acquire you as a customer. They put you on a drug.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
That drug has side effects. They have to put you on another drug to mitigate the side effects of that drug. Now you've got side effects from that polypharmacy. They have to put you on another drug to mitigate those side effects. And now you look up and people who are 50 to 60 years old and older are on 10, 12, 18 different medications. That's the best financial model in the world.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So it's a great financial model, but it's at the expense of our health and the health of everybody living in the world. And in the U.S., you know, we have the sickest population in the world. Now, for the first time in the history of Western medicine, have discussions between physician and patient, how do we wean you off this drug?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
That conversation has never had before because it's always, if this doesn't work, come back and I'll prescribe you more drugs. Let's do the opposite. You come back and let's understand the root cause of disease. Let's say, okay, well, if we are addressing this, you don't need this medication. And if you don't need this medication, you don't need this medication.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, well, thanks so much for having this conversation with me. I think that illustrates the problem, right? Someone as informed as you don't know anything. I've never heard of nitric oxide.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And now for the first time, you start weaning patients off of drugs. And what happens? You're now impeding upon the market share of these multi-billion dollar drug companies who make their living buying influence, regulating policy, influencing policy, And the FDA is a stepping stone to a board seat of Big Pharma. Every former FDA official in the U.S.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
for the past 20 or 30 years goes on to become multimillion-dollar salaried employee from Big Pharma. It has to stop.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, I mean, that's depressing. I mean, but those are the facts. And you have to understand, those are indisputable data, right? And so when people hear that, they go, but when you look at kind of the system, and I don't blame doctors because doctors are getting into this field. You know, I was on the admissions committee to UT Medical School for a number of years.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So we interviewed a lot of these young kids, figured out what their motivation was. Will they have a successful career in medicine? And almost everyone, I mean, there's always the exception, but everyone gets into medicine because they want to make a difference. They're driven by curiosity. And most of them want to leave a lasting legacy and help people. That's what drives entry into health care.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But when you look at the system in which they're trained in, it prevents them, it basically handcuffs them. Because when you figure out the pay, the economic model of medicine, once you make a diagnosis, now you've got a diagnosable disease to which you have a finite number of responses, right? If you make this diagnosis, that's called an ICD-10 code, which is reimbursable,
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And that's how you get paid. So once you make a diagnosis, you only have a finite list of things you can do. You can't ask that question and go, well, what's really causing this and spend, you know, 90 minutes with that patient. Because most physicians have to see 60, 70, 80 patients a day to pay the bills, to cover their overhead. So it's a factory.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You come in, you look at it, you've got a transcriber, you make a diagnosis, okay, I'm going to prescribe this medication, come back in two weeks or six months and we'll see where you are. And then it's just, it's a churn, it's a meal. But as you meant, the data don't lie, right? Sickest population, highest infant mortality in the most industrialized nation in the world.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, again, longevity is this emerging field that's driven by how do we live longer? How do we increase our healthspan and longevity, right? Because I think we can all agree that nobody wants to live to be 100 years old if we spend the last 25 of that year as incapacitated, in a diaper, unable to get out of bed, right? That's not living.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So when I look at longevity, I look at kind of what are the hallmarks of longevity? What defines longevity, right? How do we live longer, healthier life free of disease? And really there's three objective measures. There is stem cells.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, this whole field of regenerative medicine is based on mobilizing our own stem cells or deploying stem cells throughout the body to repair and replace dysfunctional cells.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, very good point. So this is not nitrous oxide. Nitrous oxide is, I mean, in medicine, it's a dental anesthetic, right? It's a gas. It's called laughing gas. That's N2O. It's the chemical formula. What we're talking about is nitric oxide or NO, one nitrogen, one oxygen. But yeah, they sound very similar, but they're completely different.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, we call them pluripotent stem cells. So mean that, and some of these are bone marrow derived. Some of these are what we call stromal vascular fraction that you get from the adipose tissue or the fat.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Pluripotent means that stem cell can go and become a neuron. That stem cell can go to the heart and become a functional myocyte. It can go and become a macrophage or an immune cell, white blood cell. So pluripotent means it can become many things, whatever it needs to be. In some cases, the amount of stem cells present in our bone marrow get smaller with age. The number of cells decrease with age.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But fortunately or unfortunately, the older we get, the more fat we deposit. And so we have a number of stem cells in our fat, so we increase the number of stem cells in our fat. So the problem with aging and longevity is when we lose the ability to mobilize our own stem cells, we can't repair and replace dysfunctional cells. So we have what we call zombie cells or senescent cells.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
They're there, but they can't do their job. They're dysfunctional. And that's what leads to age. Number two, it's telomeres. And telomeres are the ends of the chromosomes of our DNA. And so they're the very end. So it's like the... the tips of the shoestrings, right? That prevent the shoestring from fraying.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And those are like the telomeres. So as long as you have a functional telomere and it prevents it from getting shorter, then shorter telomeres, shorter lifespan. Longer telomeres, longer lifespan. So when telomeres get shorter, it decreases our lifespan and longevity. And then the third one is mitochondrial function.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Every age-related chronic disease, you have a lower number of mitochondria per cell, and the mitochondria that are present aren't functional. So you get what's called an uncoupling of the electron transport chain inside the inner mitochondrial membrane, and you can no longer effectively produce cellular energy or ATP.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So nitric oxide is the foundational longevity molecule because nitric oxide is the signal in the body that tells our stem cells to mobilize and differentiate. Without nitric oxide, you have less number of circulating stem cells. Nitric oxide activates the enzyme telomerase, which prevents telomere shortening. Without nitric oxide, you don't get activation of telomerase. Telomeres shorten.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And then nitric oxide is the signal in the cell that tells the cell, I need more mitochondria and I need these mitochondria to be more efficient, generate more cellular energy with less oxygen. So when you restore nitric oxide, you address all three aspects of longevity. And there's no other molecule in the body that does that.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, I would never replicate or try to do what he does. I don't think it's the proper approach. You know, and I don't mean to criticize people because this whole field of biohacking, you know, you get people who have no science background, no medical background, no biochemical background, and yet they're out there influencing people millions of people that follow him.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Nitric oxide is a signaling molecule in the human body which regulates things like blood flow and oxygen delivery. And the loss of nitric oxide production is the earliest event in the onset progression of age-related chronic disease.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And many times they're giving really bad advice, not intentionally, it's because of ignorance. They just don't know. They don't know the science, they don't know the medicine behind it. So before you go and follow any influencer or biohacker, number one, look at their credentials.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And if they don't have any science background, if they're, you know, formal technologists or, you know, come from anything besides science and medicine, you really need to do a little bit of deep dive and make sure that what they're giving you is scientifically valid or recommending.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
This molecule is foundational for human health and longevity. So nitric oxide is a gas. It's a naturally produced molecule. It's a signaling molecule in the human body. And so it regulates things like blood flow and oxygen delivery, and it mobilizes our own stem cells to help us recover and repair and replace dysfunctional cells that improves energy production inside the cell.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, I think as we advance the science and we do more to communicate the complex science into layman's terms where the non-scientists, non-medical professionals can understand it and appreciate it, I think more people are going to pick up to that.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But there's also some well-known biohackers with influences of millions of people that still say that nitric oxide is a toxin that inhibits mitochondrial respiration and it should be avoided.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Absolutely. We know water is essential, right? But we can drink too much water and kill ourselves. You see it on the news a couple of times a year called hypotonic lysis. So yeah, dose dictates poison.
The Diary Of A CEO with Steven Bartlett
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And so what we have to do is make sure, maintain the integrity of the field to make sure that if there are nitric oxide products out there, that number one, you don't overdo it and lead to health issues or kill a consumer or kill a patient. Because that could kill the entire field. But we also understand that there's only two signs of toxicity for nitric oxide.
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So it's really pretty straightforward. Number one, if you take too much nitric oxide, you're going to get an unsafe drop in blood pressure. Just think about this. If you take nitric oxide or you're enhancing nitric oxide production through whatever means, it's going to lead to systemic vasodilation.
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Now you've got that same volume of blood pumping through much larger pipes, and you're going to have a drop in blood pressure. And if you lose perfusion pressure, you're not going to be able to perfuse the brain because you've got a pump against gravity, and you're going to get lightheaded and you'll pass out.
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And if that's prolonged, it leads to ischemic end organ damage and organ failure, and it can be deadly. So that's number one. And then number two is a condition called methemoglobinemia. And that's a big word, meaning that it oxidizes the iron of hemoglobin and reduces your oxygen-carrying capacity. So you'll become cyanotic. You'll get blue around the lips.
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Your extremities will turn white from lack of perfusion or lack of oxygen. But you never see that. I mean, you really never see clinical methemoglobinemia. Fortunately, your blood pressure will drop to an unsafe level long before you get any accumulation of methemoglobinemia.
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Absolutely. So we understand at the DNA level, at the nuclear level, that nitric oxide is what's called a co-localizes with estrogen receptor to allow for the cell to turn on transcription and translation of the telomerase enzyme. So it's not only affecting the genetic transcription of that protein, but it's also regulating the function of the enzyme.
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So without nitric oxide, you have less telomere telomerase enzyme, and that telomerase enzyme isn't functional.
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So what happens with each cellular division, those telomeres can get shorter.
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And it regulates blood flow. When we begin to exercise, if we want to recall memory, that's dependent upon adequate blood flow to the organs. It's intimately involved in sexual activity and dilation of the sex organs for sexual function. So what we're finding is that the older we get, the less nitric oxide we naturally produced.
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Right? But as long as that telomerase enzyme is active, it prevents the shortening of the very ends of the chromosome.
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Yeah, and different cell types have different replication rates, right? So the epithelium of the gut is highly regenerative, right? It's replicatable. We're replacing these cells all the time because it's the outside environment that you're having to continue to replace those cells. Neurons, to the exact opposite, aren't regenerative by nature. So we don't typically make them. I mean, we can.
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It was once thought that you can't regenerate neurons, but today we know we can't. But yeah, so it affects different organ systems differently. But the data are clear, shorter telomeres, shorter lifespan.
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Yeah.
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No doubt. I mean, this is probably 20-year-old science where we find that, you know, probably 20 years ago, the microbiome project was complete. And what that means is that the bacteria that live in and on our body were completely mapped out. And these communities were identified in the gut, started in the gut, the gastrointestinal tract. And then, you know, you can culture the skin flora.
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There's bacteria that live on our skin. There are bacteria that live in our colon. There are bacteria in women that reside in the vagina. And so all of these different ecologies of bacteria that live in and on the body are there to do things to help the human host. We call this symbiosis. We're providing benefit to the bacteria and the bacteria providing benefit to the human host.
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And so if we use antibiotics or antiseptics to kill the bacteria that live in and on our body, you get human disease. I mean, that's clear. And the best example is that there's no physician in the world that would recommend you or I take an antibiotic every day for the rest of our lives. Right? Do you agree with that?
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And why is that? Because the antibiotics are killing the good bacteria. They kill the infectious pathogen bacteria, but they also destroy the entire microbiome. And when you disrupt the microbiome, you get systemic disease.
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You get vascular disease, you get Alzheimer's, you get leaky gut syndrome, you get autoimmune disease, you get high blood pressure, you get yeast infections, you get overgrowth of candida, you get parasites. So the bacteria are really the police of the human kind of surveillance. So we have 10 times more bacteria cells that make up the human than we have human cells.
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And now today, that's recognized as the earliest event in the onset and progression of age-related chronic disease. So my mission is to inform and educate the global population
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So we're 10 times more bacteria than we are human. And so if you destroy that microbiome, then it leads to systemic disease.
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And again, you look at epidemiological data, kids who grow up in a rural area, they're out in the environment, they're rolling in dirt, they've got dirt on them, and they're inoculated with a lot of bacteria. Those kids are the healthiest people. And you look later in life, they have lower incidence of cardiovascular disease, diabetes, they have better immune dysfunction, less autoimmune disease.
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So there's this whole hygienic principle or hygienic hypothesis of disease. And I don't think it's a hypothesis anymore. I think it's proven out. So for me, I go back and I go, why are we doing this? Why are we using fluoride rinses in dental offices? Why is there fluoride in our toothpaste? Why is there fluoride in the municipal water of 72% of municipalities in the U.S.?
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When fluoride is a known antiseptic, it's a chemical toxicant, it's a thyroid toxicant, it kills your thyroid, and it's a neurological toxin. And so when you go back and look at the history of dentistry, over 100 years ago it was first identified that oral bacteria can be found in the plaque that killed someone from an acute heart attack, right?
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People who died from sudden cardiac death, they'll take the thrombus or the embolus that occluded that coronary artery, and they basically biops it, and they find oral bacteria in that plaque that caused the heart attack or stroke. So that told us there's an oral systemic link. There's bacterial translocation of the pathogens. That's why bleeding gums are a problem.
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on how important, number one, what nitric oxide is, how it's produced in the human body, what goes wrong in people that can't make it, and then perhaps most importantly, how do we prevent that age-related decline in nitric oxide production so everybody can be empowered to take control of their own health and prevent age-related disease.
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Because you've got bacteria in the mouth, you've got bleeding gums, there's open blood vessels for those bacteria to get into our blood supply. Now they become systemic, cause inflammation, plaque rupture, and heart attack and stroke. So 100 years ago, with reason, with good reason, they go, well, let's treat with an antiseptic.
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We have to kill all the bacteria in the mouth, so if you have bleeding gums, there's no translocation of that into systemic circulation, and we can prevent heart attack or stroke. That was 100 years ago, and we've learned a lot in those 100 years. Number one, it wasn't recognized that we have a microbiome on our body, in our body. So now, when I ask dentists all the time, why do you use fluoride?
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And they go, well, it's been used for 100 years. And I go, I don't care what the question is, that's the worst answer you could provide. Just because we're doing it because that's the way we've always done it. Right? So now we have to understand, how do we selectively kill the pathogens while maintaining a healthy microbiome?
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And so this field started probably in the, I mean, some of the first papers were published probably in the 90s, showing that there were, if you use mouthwash, it destroyed the microbiome, and we saw an increase in blood pressure. These papers were published in the late 2000s. We published on this probably in 2008, 2009. We created what's called an association.
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So people who had the healthiest and most diverse bacteria in their mouth had the best blood pressure. people who had the least diverse oral microbiome, and we could not culture any of these nitric oxide-producing bacteria, appeared to have the highest blood pressure. So that's what we call association. It's not causation, but it's a nice association.
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So in 2019, we published a paper showing, okay, now let's see if we take normal intensive patients, young, healthy people with good nitric oxide, good blood pressure, and we just give them mouthwash twice a day for seven days to kill the entire oral microbiome. And then we do tongue scrapings to see if we're killing the bacteria, and we do blood pressure measurements.
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And so we do that twice a day for seven days. Seven days, we bring them back in, we measure their blood pressure, And then we stopped for four days. We said, okay, don't take mouthwash for four days. Then come back, let's remeasure your blood pressure, and let's do tongue scrapings and figure out what's happening to these bacterial communities.
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And what we found was that if you eradicate the bacteria, within seven days your blood pressure goes up.
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I think it occurs earlier. But we looked at seven days. We only looked at day one at baseline, seven days, and then four days after stopping the mouthwash. But in one 21-year-old kid, his blood pressure went up 26 millimeters of mercury.
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And that's what the science tells us, but as you illustrated, most people have never heard of this.
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That's clinically hypertensive. So for every one millimeter increase in blood pressure, that increases your risk of cardiovascular disease by 1%. So within seven days, we increased this kid's risk of cardiovascular disease by 26% simply by giving him mouthwash.
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Well, we're still trying to understand mechanism. Again, we're at the observational level that's really indisputable. Because these bacteria, there's what we call nitrate-reducing bacteria. And humans do not have this enzyme. So nitrate is what's found in green leafy vegetables, right? These plants assimilate nitrogen in the soil in the form of nitrate. We consume these vegetables.
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The nitrate is taken up in the gut. It's concentrated in our salivary glands. And the bacteria... perform this metabolism of nitrate into nitrite and nitric oxide. And humans do not have the functional enzyme to do this. We're 100% dependent upon the bacteria.
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So then now, because nitrate is inert in humans, we rely on the bacteria to metabolize this molecule into a usable form where we can make nitric oxide. So when you're killing the bacteria, now the nitrate is just being recirculated, but you're urinating because it's filtered across the kidneys. You poop it out and you sweat it out. So it's completely unchanged unless you have the right bacteria.
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And what we're finding is that that oral production of nitrite and nitric oxide being produced in the acid environment of the stomach is somehow regulating resistance arteries in dilation to normalize systemic blood pressure.
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As it relates, there are many benefits of many nutrients in foods, particular plants, that confer some health benefits. But when we focus specifically on the benefits of nitric oxide from your diet, if you don't have the right oral bacteria, you get zero nitric oxide benefits from your diet.
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Now, you're going to get, you know, obviously, hopefully vitamin A, vitamin C, vitamin D from foods, fiber, other phytonutrients. But in terms of the blood pressure lowering effects of, for instance, a plant-based diet, if you don't have the right bacteria, you get zero benefits of that.
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Well, you know, if you look at population-based studies at different age groups, we see about a 10% to 12% decline in what we call endothelial function per decade. So nitric oxide is a gas. It's produced in the endothelium. So the endothelium is the single layer of cells that line every blood vessel throughout the body.
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Yes, absolutely.
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People that have dental infections, root canals, cavitations from previous extraction sites, have typically cancer. It sets the stage for cancer cell growth and proliferation. So I made a controversial statement on a previous podcast where I say, number one, I'm not an oncologist.
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But people who have terminal metastatic disease who aren't ready to die, who are sent home to die on hospice, somehow find me and go, can you help me with this cancer? So the first thing I always send them to is a dentist. to see do you have any active oral infections that may have led to the development of the primary tumor in the first place.
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But obviously it's metastatic, meaning that it's now everywhere. It's migrated outside that primary tumor. But almost always without fail, they have an active oral infection. And it may be a symptomatic infection to where they know it and they have a toothache, or it may be an asymptomatic infection where they don't even know they've got a dental infection.
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People with primary tumors, solid tumors, so we categorize these in blood-borne cancers, something like lymphoma, leukemia, multiple myeloma, which is a blood-borne cancer, and those that have a solid tumor, a primary tumor that starts in the breast, the colon, the prostate, the lungs, or the liver. Without fail, 100% of them have dental infections.
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So things like erectile dysfunction, diabetes, Alzheimer's, high blood pressure, which is the number one driver of cardiovascular disease, which is the number one killer of men and women worldwide. And 50% of the patients that are treated with prescription medication don't respond with better blood pressure because they aren't targeted toward nitric oxide. But most people have never heard of this.
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Cause and effect, no, I don't think we're there yet. I think probably as the science advances and people start to look at this. Because you may imagine...
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If you have cancer and you've been to the best cancer doctors in the world and you've done surgery, you've done chemo, you've done radiation, you've gone through the standard of care and the cancer comes back, it's terminal, it's metastatic, and you tell, when I tell people, well, you need to go see a dentist. I mean, many people laugh and they go, what in the hell did you just say?
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I've got cancer. I don't have a dental problem. And I go, well, perhaps you do. Because again, if you go back, and I always look back, what's held true throughout ages? And if you look at Ayurvedic medicine, if you look at traditional Chinese medicine, if you look at acupuncture, and if you go back and you look, if you don't know what to look for, you're never going to find it.
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If you know what to look for, it's out there. It's in the published literature. But every tooth in the body is connected to an organ system, right? And so these are the meridians, the acupuncture meridians. You know, the analogy is they're circuit breakers. So if you trip a breaker in your home, there's no electricity going through that circuit.
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So your oven doesn't work, your refrigerator doesn't work, your lights go out. Well, the body is electric, right? And how do we diagnose death? No electrical activity, right? Either through an EKG or an EEG. So the body is electric and we're batteries. And so if that red light comes on on our phone, it says we have a low battery, everybody panics and goes and plugs it in and charges, right?
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And the human body is the exact same. We lose voltage over time. And if you've got a trip breaker from an infected tooth, there's no voltage, there's no circuitry going to that meridian that feeds individual organs. So the best example is if you've got a root canal, and 100% of root canal teeth are infected. And when you think about it, people go, well, that's not true.
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So the function of these endothelial cells is to regulate vascular tone and to regulate solute exchange and extravasation or transport of molecules across that endothelial layer.
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Well, think about what a root canal is. You had a toothache at some point because of an infection. So you go to the dentist and they pull the nerve root out of that tooth. So you don't feel the pain anymore because there's no nerve root there. And they pull the blood supply out of that tooth. Now you have no blood supply to that tooth. And a tooth is a crystalline structure. It's a living organ.
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With no blood supply and no nerve root, that's a dead tissue. So if you were to go in and we'd disconnect your gallbladder, for example, and just cut the blood supply to it, the nerve supply to it, within seven or 10 days, you'd be dead from sepsis. Nobody leaves dead tissue in the body. And so then what happens is when you leave the dentist, what do they do? They put you on an oral antibiotic.
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But they must have forgotten they took out the blood supply to that infected site. So an oral antibiotic isn't going to reach the site of infection. I mean, to me, when you sit back and think about this and go, who the hell does this and why do they do it? Well, it's because of what we've always done. So then what happens is these anaerobic bacteria, they don't need oxygen.
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They're sitting there in an anaerobic, low oxygen environment, and they're just eating away at your jawline. They're just like us do. They metabolize, they take stuff in, they poop waste out. Those waste products accumulate, it shuts down voltage, and they eat away at your jawline. So then you've got osteonecrosis, osteomyelitis, and you don't even know it. And an x-ray will not show it.
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And most dentists, unfortunately, still use x-rays instead of a higher resolution CT.
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And so when your endothelial cells can no longer make nitric oxide gas, they no longer dilate, so the blood vessels become constricted, you start to get inflammation, you get stiff arteries, plaque deposition, and that's what starts cardiovascular disease or atherosclerosis.
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Well, I think the most important thing we've learned is what you shouldn't be doing. So it's not what should we do, it's what we shouldn't be doing. Number one, we have to get rid of fluoride. You know, just this past weekend, I was speaking at a dental conference in Salt Lake City, and there were people there from the National Toxicology Program. which in the U.S.
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is the organization tasked with, if there's any kind of risk of exposure of environmental toxicant, they're charged with doing the toxicology studies to see if there's an increased risk. What is the risk? And is there a safe level that is without risk? And what they report is that fluoride, there's no benefit of fluoride, and it's all risk. It lowers IQ in kids by as much as seven points.
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and it shuts down your thyroid function, and it's a neurotoxin. And as I mentioned before, most toothpaste has fluoride in it. And if you read the back of your toothpaste, it will tell you, at least in the US, I don't know about in other countries, but it says, if you swallow this, call poison control. Because it's a poison. They're putting poison in toothpaste.
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And then if you also pay attention, it says only put a pea-sized amount of toothpaste on your toothbrush. A pea-sized. But everybody that I know fills the entire bristle of the toothbrush with toothpaste. So that's about 10 or 15, sometimes 20 pea-sized amounts of toothpaste. And a pea-sized amount of toothpaste contains about half a milligram of fluoride.
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Now, if you're using 10, 20 times more than that pea size, now you're exposed to 5 milligrams, 10 milligrams of fluoride. And you don't even have to swallow it. This is a very small molecule, a molecular weight of 19. So it's absorbed directly across the buccal mucosa, the oral cavity, and it becomes systemic.
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Well, we know there's a hierarchy, right? So the first sign and symptom of nitric oxide deficiency is usually erectile dysfunction. And when you think about this, when we're stimulated or we're about to have intimacy with our partner, we have to dilate the blood vessels.
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No, you shouldn't.
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Now, tongue scrapers, the data, again, that's time-tested. That's an ancient practice. And even in our study, we found that people who do tongue scraping have a more diverse oral microbiome, and they seem to have better oral health.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, if you're going to plant a garden, do you plant a garden on untilled soils?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So you have to till the soil, right? You got to break up the soil so the seeds actually can be aerated and you break up that biofilm. Yeah, you take the back of the dorsal tongue, I mean, almost to the point of the gag reflex, and you just pull that... ideally copper, tongue scraper forward, and you're going to see this goop coming in there.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But it's kind of like tilling the soil, and it's increasing the diversity of the dorsal part of the tongue, the microbiome.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
In that regard, yes. But what we found was in that one kid, we saw the greatest increase in blood pressure. If you tongue scrape and use antiseptic mouthwash, that's the absolute worst scenario.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Just think about this. You're tongue scraping, you're opening up the pores, and now you're using mouthwash. It's better to easily penetrate deep in the crypts of the tongue and more effectively kill the bacteria.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Absolutely. And no antiseptic mouth rinse. Okay.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, I think that's a good proactive practice because you need to look at the health of the gum tissue and the gingival tissue. And a routine clean and scraping the plaque off the teeth and making sure you have good mineralization of the enamel of the tooth is good, but never let them do a fluoride rinse on you.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So when erections in both men and women are dependent upon dilation of the blood vessels to get engorgement, to get increase in blood flow, and that's what an erection is. But if those blood vessels can't make nitric oxide, the blood vessels don't dilate, so there's no increase in blood flow, there's no engorgement, and that's by definition what we call erectile dysfunction.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, there's also data showing that if you use mouthwash, you lose the cardioprotective benefits of exercise. So think about this. We know that diet and exercise is the best medicine. And many people aspire to do that. They go and they try to eat good. They avoid the temptations of sugars and sweets. They exercise every day to try to increase their longevity and cardiovascular health.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
If you do that and you're using mouthwash, you no longer get the benefits from exercise. And we've already established you don't get the nitric oxide benefits from diet. So two out of three Americans wake up every morning and use a mouthwash. And two out of three Americans have an unsafe elevation in blood pressure.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, because you're killing the oral microbiome that's partly responsible for production of nitric oxide.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Without nitric oxide, you get constriction of blood vessels, and it leads to high blood pressure.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, so this is a two-way street. So in men, testosterone activates nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
In women, estrogen activates and stimulates nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So as long as we have optimal sex hormones and as long as the enzyme in the lining of the blood vessel can functionally produce nitric oxide, that explains the cardioprotective benefits of hormone replacement therapy. Okay.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
As long as the enzyme is functional and coupled. which means that we have to understand the enzymology and the biochemistry of that reaction to where when it's exposed to testosterone, the cell can actually make nitric oxide in response.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, think about it. I mean, there's other agonists too, like vitamin D. I mean, most Americans are deficient in vitamin D. People with low testosterone have erectile dysfunction. And why is that? Because they're not stimulating nitric oxide production and they're not dilating the blood vessels, so they develop ED.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So all of this, no matter what it is, whether it's related to vitamin D deficiency, which is activating or stimulating nitric oxide, if it's low hormones, if it's a poor diet, sedentary lifestyle, all of that can be explained by insufficient nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I think the same answer is for that too. It's not so much what we should be eating, it's what we should not be eating.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So we'll cover those step by step. Number one, you have to avoid sugar and high glycemic index foods. Because sugar is a toxin, it's a poison. And let's think about what sugar is. So when we eat sugar or drink sugar beverages, right, whether it's sucrose, whether it's fructose, whether it's high fructose corn syrup, the end result inside the human is we see an increase in glucose.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And it's the same in men and women, right? Whether it's the penis or the clitoris or the labia, you have to have an increase in blood flow. And without nitric oxide, there's no increase in blood flow. So that's number one. And we call that the canary in the coal mine. Because for years, people thought it was a lifestyle disorder, right?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So elevation in blood sugar or blood glucose is diabetes, right? And now there's continuous glucose monitors that you can get anywhere. And everybody does this. So if you eat something and it causes an increase in your blood sugar, blood glucose, then you should avoid that. Because glucose, as the name applies, is glue, right? It's sticky.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And if you have a soda and you spill it on your countertop, you come back the next day, it's sticky, right? That's what happens inside the body. That sugar sticks to everything. It sticks to proteins. It sticks to enzymes. It binds to hemoglobin. And sugar stuck to hemoglobin is what we call hemoglobin A1c. And what is that? It's a marker of long-term glucose control.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
If you have hemoglobin A1c of greater than 5.7, you're diabetic. So it's not just hemoglobin it sticks to. It sticks to the enzyme that makes nitric oxide. And in biochemistry and enzymology, enzymes have to be able to undergo conformational changes, right? So it transfers electrons from one donor to an acceptor, and that's how biochemistry is done.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But if sugar is stuck to that enzyme, it locks it in some conformation, and it can't do its job. For instance, it can't make nitric oxide. So sugar is an absolute poison, and it kills many enzymes and binds to everything.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Absolutely. That's why diabetics have a 10-time higher incidence of heart attack, stroke, all-cause mortality. That's why they develop peripheral neuropathy. That's why they have non-healing wounds. There's no nitric oxide. That's why they're developing diabetic retinopathy, macular degeneration, pancreatitis.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I mean, all of that can be traced back to a lack of nitric oxide production because the sugar is stuck to the enzyme. The sugar destroys the oral microbiome and completely changes the ecology of the bacteria and completely shuts down nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, diabetic ulcers.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
apply the nitric oxide serum. It'll stimulate blood flow to that. It'll improve cellular turnover and heal that wound and basically remediate the scar.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But now it's recognized that it's a symptom of loss of nitric oxide and really an accelerated form of cardiovascular disease. So we have to focus on the vascular component of erectile dysfunction.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, so you take one pump from each side.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And we turn it around, one pump from the other.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And now if you apply that and mix it together, as soon as you mix it together, it starts to generate nitric oxide gas. So then that gas will diffuse into that tissue. It's going to increase blood flow. And it's going to mobilize stem cells. And it's going to improve cellular turnover and completely remodel that and heal that.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And if it were an infection in there, it would kill the infectious bacteria.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, you've got to eliminate sugar. And I think the benefits of a straight ketogenic diet or a straight vegan vegetarian diet is just the elimination of sugar and carbs.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Right. But I think to answer your question, what should we be eating? I think you've got to eat a balanced diet in moderation. You know, Americans are overfed. All you got to do is walk around and see the epidemic of obesity. Good high quality protein, good quality fats, and little or no carbs. And it's really that simple.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Beets, yeah, the beets hit really the airwaves back in 2012 in the London Olympic Games. There was a lot of data coming out at the time of the benefits of beetroot juice on enhancing athletic performance. And there was a benefit of the nitric oxide being produced that could explain the improvement in athletic performance.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
The problem is these athletes were drinking liters and liters of beetroot juice and causing a lot of gastric discomfort, causing diarrhea. Their urine and their feces would turn red, and a lot of people misinterpreted that as gastric bleeds or urinary bleeds.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And then when I started looking at the products on the market, most of the beet products, the desiccated beet powders, provided zero nitric oxide benefit. They didn't contain any nitrate, no nitrite. They were just, we called them dead beets. They're a dead beet product.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so I thought if consumers are out there looking for beets because they've been shown to enhance their performance, but that enhancement in performance was dependent upon the beet's ability to improve nitric oxide production in the body, then the non-scientist out there wouldn't know what to look for, right? They're buying products that aren't providing any benefit to them.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so years ago, we would do randomized placebo-controlled clinical trials, and we would take some of these commercial bead products that you can go to your local nutrition store or pharmacy, buy off the shelf, and we would use those as placebos in our clinical trials because it's the perfect placebo.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So what I tried to do in that book is educate, okay, what is it about beets that are so important? What's the mechanism and what is necessary in those beets that can improve nitric oxide production?
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Deficiency. So if you don't correct the ED, then what you start to see is an increase in blood pressure. And when you think about this mechanistically, so we have a finite volume of blood that's pumping throughout our body every day, every second. And if you can make nitric oxide, the blood vessels are more dilated. So now we're pumping that volume through more dilated blood vessels.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So again, everything I do is intended to educate and inform the consumer so that they know how to make informed, educated choices on the products they're taking or the foods they're eating or their oral hygienic practices.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, that may be in the Beat the Odds. I thought it was in this book. But if you go back to historical times and you look at the hieroglyphics on caves of the ancient cavemen, You know, people thought they were drinking wine because they would have these red stuff in this before battle.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But what these ancient Egyptians were doing was they were drinking beet juice to improve their performance before they went into battle so that they were ready, they were energized, they improved their circulation. So that's the historical study on beets. And obviously, these were beets grown at a time when there were no herbicides, pesticides, and the soil was probably fertile.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So these beets were full of nutrients, probably full of nitrate that provided the benefits of that. But unfortunately, today, the beets that are grown, at least in America, really are nutrient depleted, just like most of the food.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, because, again, through our survey that we published in 2015, we realized that you really can't eat enough beets to get enough nitrate to improve your performance. And the other caveat is that if you're using mouthwash, you've got fluoride in your toothpaste or fluoride in your drinking water that you're mixing the beet powder in, you're not going to get a nitric oxide benefit from it.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Oh, yeah, from 2004 to... So a 20-year period, we're seeing... What is that? Almost a quadrupling of the use of antacids. And this is globally or is this in the US? That's worldwide, I believe. Yeah, worldwide. Now, this is the problem. I mean, these antacids... What is an antacid? So it's a medication that's given orally to suppress stomach acid production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And as a biochemist and physiologist, I can't think of nothing more damaging than to inhibit stomach acid production. Because stomach acid is required to break down proteins into amino acids, whether you're eating animal protein or plant-based protein. It's required for nutrient absorption. You need stomach acid to absorb B vitamins.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You need stomach acid to absorb selenium, chromium, iodine, magnesium, iron. I mean, most nutrients, micronutrients, are absorbed in the lumen of the stomach. And if the stomach is not making stomach acid, then these nutrients are not absorbed. And most Americans, 75% of Americans are deficient in magnesium. 95% of Americans are deficient in iodine. I mean, it's a huge problem.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
No, these are like the Prilosec, the Prevacids, the Nexium, the prescription medications are Omeprazole, Pantoprazole. Today in the U.S., I think it's probably worldwide, you don't even need a prescription for these from your physician. You can go to your local drugstore and you can buy these, what we call proton pump inhibitors or PPIs. What about Tums? Over the counter.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But if we lose the ability to produce nitric oxide, now you don't get the dilation. Now you have smaller blood vessels. You're pumping that same volume of blood through smaller pipes, and simple physics tells us that blood pressure goes up.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So there's a difference in—so Tums and things like baking soda are a buffer, right? Sodium bicarb or calcium carbonate, and it's a buffer, right? So if you have an acute bout of hypersecretion of acid, you can take a Tums or some buffer, some base, alkaline substance, to neutralize the acid.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Neutralizing acid is completely different than inhibiting its natural production in the polyuric cells of the stomach.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, there's certain classes of antacids. There's what we call H2 blockers. There's proton pump inhibitors. And then there's the natural buffers that are just kind of neutralizing the acid environment in the stomach. Gaviscon, I'm trying to think what class that falls under. I don't think it's widely used here in the U.S. I mean, the main drugs used here are Prilosec, Nexium, Prevacid.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Those are the over-the-counter. And then the main prescription medications are the Omeprazole and the Pentoprazole.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Oh, so Gaviscon, so number one, it's got aluminum in it, which should absolutely be avoided. But yeah, it looks like a buffer. It's got an aluminum hydroxide, which is a strong base, so it's neutralizing the stomach acid production. But it's a neutralizing agent, but anything that contains aluminum, you should absolutely avoid.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, when we talk about the enzyme that's found in the lining of the blood vessels, when we started this segment, that same enzyme is found in our epithelial cells, in our upper airways, in our sinuses. So just like exercise can activate nitric oxide production in the lining of the blood vessels, deep breathing, nasal breathing activates that enzyme in the epithelial cells of our sinuses.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so when we do nasal breathing, it's activating the enzyme to make nitric oxide. And now we're delivering that nitric oxide gas into the bronchioles, the lower airway. It's dilating those bronchioles. Moreover, it's dilating the pulmonary arteries. So now we're improving oxygen uptake, oxygen delivery. And that's why nasal breathing and deep breathing has been shown to lower blood pressure.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, you're going to have high blood pressure or hypertension. And at least in the U.S., and I think these statistics probably are worldwide, but two out of three Americans have an unsafe elevation in blood pressure. And 50% of the people that are given prescription medications to treat their blood pressure do not respond with better blood pressure.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Oh, yeah, again, going over the past 20 years. Yeah, no, I think there's a lot of people. I mean, obviously your girlfriend, there's Patrick McKeown in the UK.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah. Now, I think the benefits of that are pretty well, and mechanistically we understand the benefits of it. So the mouth breathers are not only bypassing this natural nitric oxide production pathway, but when you mouth breathe, it completely changes the microbiome.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so you're not only bypassing the nitric oxide producing in the upper airway, but you're inhibiting nitric oxide production in the mouth from the microbiome because you're fully oxygenating the mouth. It's changing the pH of the saliva and completely changes the microbiome and completely shuts down nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So you have to, I mean, I'm a big fan of mouth taping. But for me, I know, and I watch my kids, but sometimes there's anatomical issues where there's obstructive airways and airway obstruction that has to be corrected by dental appliances or sometimes surgery. But the worst thing you can do is tape your mouth and your airway be constricted and, you know, you suffocate. Yeah.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So before you do mouth taping, you need to get some imaging done from your dentist to make sure that your airway is open to where if you're forced to breathe through your nose, you can actually have oxygen exchange.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Humming, you know, there are certain frequencies. We've done this in looking at nitric oxide coming out of the exhaled breath when you're humming. So certain frequencies can activate this enzyme. And it's dependent upon the volume of the nasal sinuses. So there's not one frequency that would work in every single person.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Because the volume of your airways and oral cavity and sinuses was probably much different than mine.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, if you just, you know, like ohms like you do in meditation or just simple humming, you could actually, so if I had my ozone or gas phase analyzer here, I could hum and I could detect nitric oxide coming out of my exhaled breath. Because of the frequency of the... Because of the frequency and activating the nitric oxide synthase enzymes.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
They don't know that if you can't walk up a flight of steps or exercise moderately for 15, 20 minutes, then you're nitric oxide deficient. They don't know that most toothpaste and mouthwash is killing the oral microbiome that's partly responsible for production of nitric oxide. But no one is interested in curing human disease because medicine is a business.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But if you take older patients, and we've demonstrated this, it's published years ago, other groups have demonstrated this. Older patients, that their enzyme isn't making nitric oxide, whether they do nasal breathing or whether they do humming, there's no nitric oxide coming out.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So again, this is an activator and a stimulator, but it's dependent upon the function of the enzyme that makes nitric oxide. If your enzyme is broken, humming, nasal breathing, exercise isn't going to produce any nitric oxide.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I think it's doing the things that disrupt it. Get rid of fluoride. Get rid of mouthwash. Stop using antacids. Stop eating sugar, anything that leads to an elevation in blood sugar. A balanced diet in moderation. Moderate physical exercise. 20 to 30 minutes of sunlight a day. Sunlight. Sunlight. At both ends of the visible spectrum, the UV spectrum and the full spectrum infrared,
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide. So that's why we call that resistant hypertension. They're resistant to traditional therapies.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So those frequencies and vibrations, again, stimulate nitric oxide release. So the UV has enough energy to where it'll knock nitric oxide bound to a cysteine thiol and protein, and then the UV spectrum will release nitric oxide down to metals.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, I have a red light bed. I have an infrared sauna that uses red lights in it, and I use it every day.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah. And there's other benefits of light. You know, it can stimulate mitochondrial biogenesis. It improves energy production. It can lower blood pressure. But yeah, lots of benefits of light therapy. And yet we're programmed to not go outside. If we go outside, put on SPF 60 and intoxicate ourselves with these cancer-causing chemicals and sunscreen. I mean, it makes no sense.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, I think the future of, well, I don't think, I know, you know, there's three levels of conviction. You think, you believe, and you know. I'm at the point of knowing now that the future of medicine and healthcare around the globe is going to be dependent upon nitric oxide product technology.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Because I think we can inform and instruct people to stop doing things or start doing things, but the most difficult thing to do is to change people's habits and to get people out of their comfort zone and stop drinking soda waters, eliminate sugar to the best extent possible, get 20, 30 minutes of exercise a day, and completely change your diet. compliance is an issue. People don't do that.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
We're programmed to want to take a pill to overcome everything. And that pill, nitric oxide, is very important, but it's not a silver bullet. It's not going to overcome all your bad habits. But what it is going to do, it's going to correct a lot of the things that your bad habits are leading to a deficiency of.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And the reason they're resistant is because it's a nitric oxide problem. And those drugs aren't designed to affect nitric oxide production or improve it.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Kim.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Happily or unhappily mated. You know, one of my biggest challenges in life is maintaining balance, right? Because I've been so focused on you know, discovery and research and leaving a lasting legacy and making innovations and doing things in the scientific and medical community that many people said couldn't be done. And so my problem is there's always a deficiency.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, I've got young kids I spend a lot of time away from, And, you know, I'm happily mated, but there's deficiencies, right? Because, again, my challenge is always maintaining balance, work, home life, kind of maintaining, you know, my spiritual, my, you know, it's mental, it's physical, and it's spiritual health.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I'm trying to do better at that now, but you know, you can't, there's always sacrifice, right? And we just have to pick our sacrifices and, you know, so I've got to choose to do better.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, I mean, obviously I'm here to educate in formal nitric oxide. You know, this latest book, The Secret of Nitric Oxide, Bringing the Science to Life, really chronicles both my kind of journey through science and medicine as you revealed kind of my early years and kind of what motivated me to go in this space.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
But I think more importantly, it tells the story of nitric oxide, what it is, what led to a Nobel Prize for its discovery, what you can do to prevent the loss of this molecule. So you can go to nathansbook.com or you can get it anywhere books are sold, Amazon, Barnes & Noble.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I've got a YouTube channel, Dr. Nathan S. Bryan Nitric Oxide, where we provide education, information, latest scientific information on nitric oxide. You can find me on social media, Instagram, Dr. Nathan S. Bryan. And then for those who want to follow our product journey and, you know, bringing forth safe and effective product technology, that's N101.com.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So it's the letter N, the number one, letter O, number one.com. But, you know, we make products that release nitric oxide.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Thank you so much. Pleasure being with you.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, for me, I was a student at LSU School of Medicine. This was the late 90s, maybe early 2000s. But a Nobel Prize had just been awarded for the discovery of nitric oxide. There were three U.S. scientists that were awarded the Nobel Prize in Physiology and Medicine in 1998. And I was very fortunate at the time. I was a young student, probably a first-year student.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And Lou Ignaro, who had just won the Nobel Prize for the discovery of nitric oxide, came and spoke and gave a lecture before the student body. And I had a chance to have a conversation with him afterwards, and I was fortunate to be invited to have dinner with him that night. And he made a very poignant statement to me.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
He goes, if the scientific community can figure out how to restore the production of nitric oxide, it'll change the world. And it'll change the landscape of medicine. Because even then, what is that, 25, 26 years ago, that it was recognized that a loss of nitric oxide production is leading to the onset and development of many poorly managed age-related chronic diseases.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So I go, that's a very profound statement from a guy who just won the Nobel Prize. But that was the first kind of eureka moment for me that stimulated the interest. But then my dad, and I talk about it in the book, his dad is 76 years old. In 1984, he had a car accident that left him paralyzed from the mid-back down.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So the majority of my life, even as a kid, I was treating dad's wounds, the cubitus ulcers, pressure ulcers on his feet, on his butt. And he developed these non-healing wounds. He was diabetic, he was paraplegic, poor blood flow, hypertension, and he developed a non-healing wound, and no wound care doc that I took him to could heal this wound.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So I started making a topical nitric oxide, and I healed this wound within a period of four years of non-healing. I healed it within six months simply by giving nitric oxide and getting blood flow to that wound, killing the infection in the wound. And this was in a 60-something-year-old paraplegic, diabetic, sedentary old man.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And the epiphany for me came because my dad had a car accident. And he developed these non-healing wounds. And I saw the failure of the standard of care to treat dad's wounds. And so I just thought that there had to be a better way. And simply by giving nitric oxide, I've healed this wound within six months.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You know, certainly it directed kind of my life because I witnessed the failure of the standard of care to treat dad with what I thought should be pretty simple. I mean, we have, again, the most advanced technology, medical technology, best medical schools in the world, and yet we can't treat a wound. We can't address the hypertension. We can't address the diabetes medically.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And so I just thought that there had to be a better way.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Yeah, but I see... You know, Dad, when I think I'm having a bad day, I just think, look, I'm not in a wheelchair. I got my health. So no matter how bad I think I got it, it could always be worse. So I just wake up every day with a grateful heart. And, you know, some days are good, some days are bad. But I always realize it could always be better, but it could be a hell of a lot worse.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So I don't complain.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I was in molecular and cellular physiology, got a PhD in molecular and cellular physiology. And that was, I was recruited by Fred Murad, one of the other guys who shared the Nobel Prize. to join the faculty at the University of Texas Health Science Center in Houston, which is the world's largest medical center, but it's part of the University of Texas system.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So I was recruited as a professor of molecular medicine, published probably, well, over 100 peer-reviewed scientific publications, I've edited several medical textbooks on the subject. I taught in medical school.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And then I resigned from academia, I guess, several years ago during COVID to focus on the next phase of my career is taking this 25 years of science and research and discovery and now bringing that to the fore for safe and effective product technology, drug therapies to eradicate a lot of these poorly managed chronic diseases that, you know, we're faced with today.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, it dilates the smooth muscle. It's not affecting the cells per se, but it's dilating the smooth muscle that surrounds the blood vessels, and that leads to relaxation and dilation.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
That's right.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
It's what you shouldn't be doing. And we'll cover those step by step.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Well, yeah, there are a lot of things that occur with aging, right? We lose growth hormone with age. We lose many hormones. Nitric oxide is a hormone. We first discovered nitric oxide as a hormone back in 2007. But to understand aging, you have to understand what leads to aging. So aging, from my perspective, is the inability to repair and replace dysfunctional cells.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
Every day we wear ourselves out, and if we can repair and replace dysfunctional cells, then we combat aging. or at least prolong the aging process. So what the science tells us in nitric oxide is this, that loss of nitric oxide production is the earliest event in the onset progression of age-related chronic disease.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So as that graph implies, it is part of the aging process, but it doesn't have to be. Because today we know we can shift that curve to the left or to the right. So we can accelerate it. And you see this today with 18-, 20-year-old kids that have high blood pressure. They have diabetes. They have erectile dysfunction. They have learning and cognitive impairment.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
And those are all symptoms of nitric oxide deficiency. And to the contrary, we see 50-, 60-, 70-year-old patients that would fit on a 30- or 40-year-old scale on that graph. So this doesn't have to be the case. We know how to prevent this age-related decline in nitric oxide production. You know, I'm the best example.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
I'm 51 years old, but I've got the vascular age of a 36-year-old because I employ these principles to prevent this age-related decline in nitric oxide production.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
You look at the sort of vascular health of your... So there's several objective measures of biological age. Obviously, we can't affect our chronological age, right? But we can certainly affect our biological age. So what you can do, there's databases now that we call carotid intima media thickness.
The Diary Of A CEO with Steven Bartlett
The Silenced Scientist: The Cure For Alzheimer's Already Exists?! Doctors Are Trapped In A Broken System! The Link Between Oral Infection & Cancer!
So they take an ultrasound and look at your carotid arteries and they can look at what's called smooth muscle hyperplasia or the thickness of the intima and compare it to a database of age-matched kind of Really, you're comparing against your colleagues. So that's one way. Another way is looking at what's called flow-mediated dilatation or endothelial function.