Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
Yeah, so this is a two-way street. So in men, testosterone activates nitric oxide production.
In women, estrogen activates and stimulates nitric oxide production.
So as long as we have optimal sex hormones and as long as the enzyme in the lining of the blood vessel can functionally produce nitric oxide, that explains the cardioprotective benefits of hormone replacement therapy. Okay.
As long as the enzyme is functional and coupled. which means that we have to understand the enzymology and the biochemistry of that reaction to where when it's exposed to testosterone, the cell can actually make nitric oxide in response.
Well, think about it. I mean, there's other agonists too, like vitamin D. I mean, most Americans are deficient in vitamin D. People with low testosterone have erectile dysfunction. And why is that? Because they're not stimulating nitric oxide production and they're not dilating the blood vessels, so they develop ED.
So all of this, no matter what it is, whether it's related to vitamin D deficiency, which is activating or stimulating nitric oxide, if it's low hormones, if it's a poor diet, sedentary lifestyle, all of that can be explained by insufficient nitric oxide production.
I think the same answer is for that too. It's not so much what we should be eating, it's what we should not be eating.
So we'll cover those step by step. Number one, you have to avoid sugar and high glycemic index foods. Because sugar is a toxin, it's a poison. And let's think about what sugar is. So when we eat sugar or drink sugar beverages, right, whether it's sucrose, whether it's fructose, whether it's high fructose corn syrup, the end result inside the human is we see an increase in glucose.
So elevation in blood sugar or blood glucose is diabetes, right? And now there's continuous glucose monitors that you can get anywhere. And everybody does this. So if you eat something and it causes an increase in your blood sugar, blood glucose, then you should avoid that. Because glucose, as the name applies, is glue, right? It's sticky.
And if you have a soda and you spill it on your countertop, you come back the next day, it's sticky, right? That's what happens inside the body. That sugar sticks to everything. It sticks to proteins. It sticks to enzymes. It binds to hemoglobin. And sugar stuck to hemoglobin is what we call hemoglobin A1c. And what is that? It's a marker of long-term glucose control.
If you have hemoglobin A1c of greater than 5.7, you're diabetic. So it's not just hemoglobin it sticks to. It sticks to the enzyme that makes nitric oxide. And in biochemistry and enzymology, enzymes have to be able to undergo conformational changes, right? So it transfers electrons from one donor to an acceptor, and that's how biochemistry is done.
But if sugar is stuck to that enzyme, it locks it in some conformation, and it can't do its job. For instance, it can't make nitric oxide. So sugar is an absolute poison, and it kills many enzymes and binds to everything.
Absolutely. That's why diabetics have a 10-time higher incidence of heart attack, stroke, all-cause mortality. That's why they develop peripheral neuropathy. That's why they have non-healing wounds. There's no nitric oxide. That's why they're developing diabetic retinopathy, macular degeneration, pancreatitis.
I mean, all of that can be traced back to a lack of nitric oxide production because the sugar is stuck to the enzyme. The sugar destroys the oral microbiome and completely changes the ecology of the bacteria and completely shuts down nitric oxide production.
Yeah, diabetic ulcers.
apply the nitric oxide serum. It'll stimulate blood flow to that. It'll improve cellular turnover and heal that wound and basically remediate the scar.
Yeah, so you take one pump from each side.
And we turn it around, one pump from the other.
And now if you apply that and mix it together, as soon as you mix it together, it starts to generate nitric oxide gas. So then that gas will diffuse into that tissue. It's going to increase blood flow. And it's going to mobilize stem cells. And it's going to improve cellular turnover and completely remodel that and heal that.
And if it were an infection in there, it would kill the infectious bacteria.
Showing 881–900 of 1,178 · page 45 of 59
← Previous
Next →