Dr. Nathan Bryan

Well, yeah, there are a lot of things that occur with aging, right? We lose growth hormone with age. We lose many hormones. Nitric oxide is a hormone. We first discovered nitric oxide as a hormone back in 2007. But to understand aging, you have to understand what leads to aging. So aging, from my perspective, is the inability to repair and replace dysfunctional cells.

Well, yeah, there are a lot of things that occur with aging, right? We lose growth hormone with age. We lose many hormones. Nitric oxide is a hormone. We first discovered nitric oxide as a hormone back in 2007. But to understand aging, you have to understand what leads to aging. So aging, from my perspective, is the inability to repair and replace dysfunctional cells.

Every day we wear ourselves out, and if we can repair and replace dysfunctional cells, then we combat aging. or at least prolong the aging process. So what the science tells us in nitric oxide is this, that loss of nitric oxide production is the earliest event in the onset progression of age-related chronic disease.

Every day we wear ourselves out, and if we can repair and replace dysfunctional cells, then we combat aging. or at least prolong the aging process. So what the science tells us in nitric oxide is this, that loss of nitric oxide production is the earliest event in the onset progression of age-related chronic disease.

So as that graph implies, it is part of the aging process, but it doesn't have to be. Because today we know we can shift that curve to the left or to the right. So we can accelerate it. And you see this today with 18-, 20-year-old kids that have high blood pressure. They have diabetes. They have erectile dysfunction. They have learning and cognitive impairment.

So as that graph implies, it is part of the aging process, but it doesn't have to be. Because today we know we can shift that curve to the left or to the right. So we can accelerate it. And you see this today with 18-, 20-year-old kids that have high blood pressure. They have diabetes. They have erectile dysfunction. They have learning and cognitive impairment.

And those are all symptoms of nitric oxide deficiency. And to the contrary, we see 50-, 60-, 70-year-old patients that would fit on a 30- or 40-year-old scale on that graph. So this doesn't have to be the case. We know how to prevent this age-related decline in nitric oxide production. You know, I'm the best example.

And those are all symptoms of nitric oxide deficiency. And to the contrary, we see 50-, 60-, 70-year-old patients that would fit on a 30- or 40-year-old scale on that graph. So this doesn't have to be the case. We know how to prevent this age-related decline in nitric oxide production. You know, I'm the best example.

I'm 51 years old, but I've got the vascular age of a 36-year-old because I employ these principles to prevent this age-related decline in nitric oxide production.

I'm 51 years old, but I've got the vascular age of a 36-year-old because I employ these principles to prevent this age-related decline in nitric oxide production.

You look at the sort of vascular health of your... So there's several objective measures of biological age. Obviously, we can't affect our chronological age, right? But we can certainly affect our biological age. So what you can do, there's databases now that we call carotid intima media thickness.

You look at the sort of vascular health of your... So there's several objective measures of biological age. Obviously, we can't affect our chronological age, right? But we can certainly affect our biological age. So what you can do, there's databases now that we call carotid intima media thickness.

So they take an ultrasound and look at your carotid arteries and they can look at what's called smooth muscle hyperplasia or the thickness of the intima and compare it to a database of age-matched kind of Really, you're comparing against your colleagues. So that's one way. Another way is looking at what's called flow-mediated dilatation or endothelial function.

So they take an ultrasound and look at your carotid arteries and they can look at what's called smooth muscle hyperplasia or the thickness of the intima and compare it to a database of age-matched kind of Really, you're comparing against your colleagues. So that's one way. Another way is looking at what's called flow-mediated dilatation or endothelial function.

And again, through database of hundreds of thousands or millions of patients, you can figure out where you fall on that spectrum on endothelial function. And then there's other markers looking at histone modification of the DNA, methylation profiles. There's a company or a technology called GlyconAge that looks at certain markers that can then define a biological age for each individual.

And again, through database of hundreds of thousands or millions of patients, you can figure out where you fall on that spectrum on endothelial function. And then there's other markers looking at histone modification of the DNA, methylation profiles. There's a company or a technology called GlyconAge that looks at certain markers that can then define a biological age for each individual.

Yep. We've touched on them. So erectile dysfunction. 50% of the men over the age of 40 self-report erectile dysfunction. That's in the U.S. So think about that. 50% self-report. I think the numbers are higher because most 40-year-olds that I know are never going to admit that they have erectile dysfunction. So I think the numbers are even worse. So that's one. High blood pressure.

Yep. We've touched on them. So erectile dysfunction. 50% of the men over the age of 40 self-report erectile dysfunction. That's in the U.S. So think about that. 50% self-report. I think the numbers are higher because most 40-year-olds that I know are never going to admit that they have erectile dysfunction. So I think the numbers are even worse. So that's one. High blood pressure.

Again, 50% of the patients that are treated with prescription medication don't respond with better blood pressure. That's a huge problem because high blood pressure is the number one driver of cardiovascular disease, which is the number one killer of men and women worldwide. Number three, metabolic disease and diabetes.

Again, 50% of the patients that are treated with prescription medication don't respond with better blood pressure. That's a huge problem because high blood pressure is the number one driver of cardiovascular disease, which is the number one killer of men and women worldwide. Number three, metabolic disease and diabetes.