Dr. Paddy Barrett

They did natural experiments whereby they basically looked at people before there was mandated shingle vaccines and after mandated shingle vaccines.

And basically, there was a significant reduction in dementia across loads of different studies, loads of different countries.

And one of the theories here is that it's less to do specifically with shingles, but more to do with the reduction of kind of inflammation infections in the brain.

Is that factored in?

a factor?

It will be a factor but it's probably going to be intimately linked to the likelihood of having blood pressure excesses and also an increase in weight and diabetes that track very closely with those.

So whether or not it's the actual sleep apnea itself would be hard to specifically say but the probability of having sleep apnea and high blood pressure and say excess weight is very high and those are both very clearly indicated as a higher risk for dementia.

Correct.

Well, the answer is the same answer.

But not only is it dementia, if you look at what's called all caused mortality, which is the chances of dying from anything.

And if you get all the core cardiovascular risk factors right, your chances of dying from anything at an earlier time point goes down significantly.

And so this is why I really kind of push this in terms of if you get heart disease right, you pretty much get everything else right that you can get right.

You can't take risk completely off the table.

But if you're tilting the odds as much as possible, you'll get heart disease right and get a whole load of spillover benefits.