Dr. Patrick Soon-Shiong

Well, that was, as you were making the introduction, I was fascinated to hear that. I didn't know that. Well, it's exactly why actually I'm working like crazy now because, you know, we have 100 patients now already accrued in this trial. And the molecule that's been tried for the Lynch syndrome patients will literally be the first cancer vaccine that's been developed.

What's exciting is that the drug got approved last year for bladder cancer. We can talk about it a little bit, you know, because what I wanted to present is pretty simple, but pretty profound. And we can get into that of these molecules we put into patients with Lynch syndrome. Because what we are activating is in your body, all of us, have nature's first responder called the natural killer cell.

What's exciting is that the drug got approved last year for bladder cancer. We can talk about it a little bit, you know, because what I wanted to present is pretty simple, but pretty profound. And we can get into that of these molecules we put into patients with Lynch syndrome. Because what we are activating is in your body, all of us, have nature's first responder called the natural killer cell.

And so far, nobody's ever tried to go and activate that with a single jab, which will ultimately be a cancer vaccine.

And so far, nobody's ever tried to go and activate that with a single jab, which will ultimately be a cancer vaccine.

That's correct. And, you know, you explained it perfectly, whether you have Lynch syndrome or not. Unfortunately, one in 280 Americans have Lynch syndrome. And because you have this deficient repair mechanism, there's an 80% chance higher risk of the cancers, colon cancer, breast cancer, ovarian cancer. But if you take the normal American or human being...

That's correct. And, you know, you explained it perfectly, whether you have Lynch syndrome or not. Unfortunately, one in 280 Americans have Lynch syndrome. And because you have this deficient repair mechanism, there's an 80% chance higher risk of the cancers, colon cancer, breast cancer, ovarian cancer. But if you take the normal American or human being...

We all actually produce these incorrect, mathematically incorrect cells, and otherwise we'd all be walking around with cancer, and why not? And the reason being is because these natural killer cells that float around in your body recognize these abnormal cells, whether they're infected with COVID, a virus, or cancer, these natural killer cells would kill it.

We all actually produce these incorrect, mathematically incorrect cells, and otherwise we'd all be walking around with cancer, and why not? And the reason being is because these natural killer cells that float around in your body recognize these abnormal cells, whether they're infected with COVID, a virus, or cancer, these natural killer cells would kill it.

And that's the work I started in 1990 at UCLA, and... That got evolved from my understanding of transplantation, that got involved in my work in cancer. And now, excitingly, we're on this verge, literally on this verge, because of the approval in 2024, of creating a molecule that activates what we naturally have to fight cancer, to prevent cancer.

And that's the work I started in 1990 at UCLA, and... That got evolved from my understanding of transplantation, that got involved in my work in cancer. And now, excitingly, we're on this verge, literally on this verge, because of the approval in 2024, of creating a molecule that activates what we naturally have to fight cancer, to prevent cancer.

Well, again, you hit on the right thing, because the fact that I was a transplant surgeon is why I got involved in immunology. You know, you look at immunologists and the other word called virologists and oncologists, they don't talk to each other. They're actually different disciplines.

Well, again, you hit on the right thing, because the fact that I was a transplant surgeon is why I got involved in immunology. You know, you look at immunologists and the other word called virologists and oncologists, they don't talk to each other. They're actually different disciplines.

And the fact that I got into immunology, because as I was transplanting my patient with the organ, the body was trying to reject it. But I was also a cancer surgeon. and doing these things called whipples. And as the patient has cancer, I was trying to find a way to reject that.

And the fact that I got into immunology, because as I was transplanting my patient with the organ, the body was trying to reject it. But I was also a cancer surgeon. and doing these things called whipples. And as the patient has cancer, I was trying to find a way to reject that.

And what I realized is that we have in our body this yin and yang cell called the natural killer cell that's been around for hundreds of millions of years. And nobody really recognized the cell until 1970. And by 1990, I did an experiment to show that if I protect the transplanted organ from the natural killer cells, I could protect the cell.

And what I realized is that we have in our body this yin and yang cell called the natural killer cell that's been around for hundreds of millions of years. And nobody really recognized the cell until 1970. And by 1990, I did an experiment to show that if I protect the transplanted organ from the natural killer cells, I could protect the cell.

Or if I activated the natural killer cell, I could kill the cancer. So yeah, I was in the schizophrenic position looking after patients on one hand on my transplant ward and on the other hand on my cancer ward. And realizing that the linchpin in this whole thing in your body is this natural killer cell.

Or if I activated the natural killer cell, I could kill the cancer. So yeah, I was in the schizophrenic position looking after patients on one hand on my transplant ward and on the other hand on my cancer ward. And realizing that the linchpin in this whole thing in your body is this natural killer cell.

So if I could activate this natural killer cell in your body with a single jab and other cells like T cells, we could drive what I call memory. And if we drive memory, we'd have a cancer vaccine.