Dr. Paul Offit

So for example, you got the XBB15 vaccine last year and you were challenged with XBB15, you decrease your chance of hospitalization, assuming you're in a high-risk group, by about 55% for three months. That's what you do. Beyond that, not as much because you've been previously vaccinated. So it's not as much.

If it's a mismatch, and it's likely to be a mismatch because if you use the XBB15 from last year, that was very quickly replaced by JN1 by the winter. So you get XBB15, then you get the JN1 challenge. It's about 33% for three months and then not as great. So this would be easier if it was like flu or RSVM was a winter disease, but it hasn't settled into a winter pattern yet.

If it's a mismatch, and it's likely to be a mismatch because if you use the XBB15 from last year, that was very quickly replaced by JN1 by the winter. So you get XBB15, then you get the JN1 challenge. It's about 33% for three months and then not as great. So this would be easier if it was like flu or RSVM was a winter disease, but it hasn't settled into a winter pattern yet.

If it's a mismatch, and it's likely to be a mismatch because if you use the XBB15 from last year, that was very quickly replaced by JN1 by the winter. So you get XBB15, then you get the JN1 challenge. It's about 33% for three months and then not as great. So this would be easier if it was like flu or RSVM was a winter disease, but it hasn't settled into a winter pattern yet.

It's still a year-round disease. So when you get it, say, October, September, October, November, you're going to be protected for that winter season, but then you still have the summer where it hasn't still settled into that pattern yet. So I think it's low risk, low reward. I think there's a benefit for those few months, and so therefore it becomes a style question. And I think the risks are low.

It's still a year-round disease. So when you get it, say, October, September, October, November, you're going to be protected for that winter season, but then you still have the summer where it hasn't still settled into that pattern yet. So I think it's low risk, low reward. I think there's a benefit for those few months, and so therefore it becomes a style question. And I think the risks are low.

It's still a year-round disease. So when you get it, say, October, September, October, November, you're going to be protected for that winter season, but then you still have the summer where it hasn't still settled into that pattern yet. So I think it's low risk, low reward. I think there's a benefit for those few months, and so therefore it becomes a style question. And I think the risks are low.

So I think it's low risk, low reward.

So I think it's low risk, low reward.

So I think it's low risk, low reward.

That historically has never happened. I mean, when you look at the side effects, severe and occasionally fatal side effects of vaccines, they invariably happen within a few weeks of getting a vaccine. So that's why the FDA enforces the fact that you have to wait till two months after the last dose before they will consider approval or licensure.

That historically has never happened. I mean, when you look at the side effects, severe and occasionally fatal side effects of vaccines, they invariably happen within a few weeks of getting a vaccine. So that's why the FDA enforces the fact that you have to wait till two months after the last dose before they will consider approval or licensure.

That historically has never happened. I mean, when you look at the side effects, severe and occasionally fatal side effects of vaccines, they invariably happen within a few weeks of getting a vaccine. So that's why the FDA enforces the fact that you have to wait till two months after the last dose before they will consider approval or licensure.

It's always been the oral polio vaccine is a cause of polio. You would see that really within a few weeks. The measles vaccine is a cause of lowering platelet count thrombocytopenia occurs really very quickly. What else? Latex, allergies, or allergies associated with some components of vaccines.

It's always been the oral polio vaccine is a cause of polio. You would see that really within a few weeks. The measles vaccine is a cause of lowering platelet count thrombocytopenia occurs really very quickly. What else? Latex, allergies, or allergies associated with some components of vaccines.

It's always been the oral polio vaccine is a cause of polio. You would see that really within a few weeks. The measles vaccine is a cause of lowering platelet count thrombocytopenia occurs really very quickly. What else? Latex, allergies, or allergies associated with some components of vaccines.

I don't think so. I mean, so when you get your mRNA vaccine, that vaccine will then enter your cell and join roughly 200,000 other pieces of mRNA that are making the proteins and enzymes necessary for life. And like all those other pieces of mRNA, it will largely be degraded within a few days. So it's not like it sort of hangs out forever.

I don't think so. I mean, so when you get your mRNA vaccine, that vaccine will then enter your cell and join roughly 200,000 other pieces of mRNA that are making the proteins and enzymes necessary for life. And like all those other pieces of mRNA, it will largely be degraded within a few days. So it's not like it sort of hangs out forever.

I don't think so. I mean, so when you get your mRNA vaccine, that vaccine will then enter your cell and join roughly 200,000 other pieces of mRNA that are making the proteins and enzymes necessary for life. And like all those other pieces of mRNA, it will largely be degraded within a few days. So it's not like it sort of hangs out forever.

What's interesting about this vaccine is this is the most potent immunization I've seen since smallpox. I mean, I had to – because I'm at the Whistler Institute and had to give smallpox vaccines for people who were – these were veterinarians who were taking a –