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Dr. Peter Attia

👤 Speaker
11186 total appearances

Appearances Over Time

Podcast Appearances

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

By the way, do we have any evidence, Sean, that there was enough genetic heterogeneity around this that there were 200,000 years ago, there were members of our tribe who simply didn't feel pain and therefore did not pass on their genes because they made poor decisions?

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

By the way, do we have any evidence, Sean, that there was enough genetic heterogeneity around this that there were 200,000 years ago, there were members of our tribe who simply didn't feel pain and therefore did not pass on their genes because they made poor decisions?

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

I find it amazing to just sit around and dream about how little convergence must have existed a quarter of a million years ago in terms of things that ended up not being good for our species, like people who didn't experience pain the same way or didn't have certain filters within themselves. There'd been lots of talk about people who couldn't socialize. You couldn't evolve alone.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

I find it amazing to just sit around and dream about how little convergence must have existed a quarter of a million years ago in terms of things that ended up not being good for our species, like people who didn't experience pain the same way or didn't have certain filters within themselves. There'd been lots of talk about people who couldn't socialize. You couldn't evolve alone.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

So if you didn't have the right set of genes that allowed you to at least be part of some sort of social tribe. And of course, we still probably have people today that have escaped. We clearly have some antisocial folks among us, but they're the exception and not the rule.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

So if you didn't have the right set of genes that allowed you to at least be part of some sort of social tribe. And of course, we still probably have people today that have escaped. We clearly have some antisocial folks among us, but they're the exception and not the rule.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

So anyway, I just wondered if today we're much more homogeneous in terms of what a human's response to pain is versus what it might have been. Probably.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

So anyway, I just wondered if today we're much more homogeneous in terms of what a human's response to pain is versus what it might have been. Probably.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

And I also think about certain things like childbirth prior to any anesthetic was obviously brutal, both in terms of the pain and the mortality. And yet there's no evidence that people were deciding, yeah, maybe we ought not to do this. In other words, the drive for procreation somehow overcame what must have been brutal.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

And I also think about certain things like childbirth prior to any anesthetic was obviously brutal, both in terms of the pain and the mortality. And yet there's no evidence that people were deciding, yeah, maybe we ought not to do this. In other words, the drive for procreation somehow overcame what must have been brutal.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Those are the two things that I joke about with my friends, which is I still don't really understand how our species is here for two reasons. One, women had to continually go back to the well. Because remember, if your reproductive rate isn't in excess of two, the species collapse. So on average, every woman must be able to do this. And back then it had to be reproductive rate of north of three.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Those are the two things that I joke about with my friends, which is I still don't really understand how our species is here for two reasons. One, women had to continually go back to the well. Because remember, if your reproductive rate isn't in excess of two, the species collapse. So on average, every woman must be able to do this. And back then it had to be reproductive rate of north of three.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Right. Every woman had to do this three times. How she did it the second two times after how bad the first was blows my mind. The second thing is just looking at how stupid adolescent males are. I'm sure you can relate to this. I was one. Yes, as was I. And I look at my boys. I don't understand why males all didn't die from just doing stupid.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Right. Every woman had to do this three times. How she did it the second two times after how bad the first was blows my mind. The second thing is just looking at how stupid adolescent males are. I'm sure you can relate to this. I was one. Yes, as was I. And I look at my boys. I don't understand why males all didn't die from just doing stupid.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

stupid, stupid things before the age of 20 or even before the age of like 15. Those two things are a miracle to our species, that all the males didn't die and that all the females were willing to have at least three kids.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

stupid, stupid things before the age of 20 or even before the age of like 15. Those two things are a miracle to our species, that all the males didn't die and that all the females were willing to have at least three kids.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

We'll link to them in the show notes, some of my favorites.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

We'll link to them in the show notes, some of my favorites.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Sometimes trying to create a distraction. Okay. Okay. Sometimes, though, probably illogical trying to keep whatever humor is in there that's hurting isolated like a tourniquet. Right. Right. Obviously, if I'm using cold, especially if it's one of my kids that hurt themselves, we'll put cold on hoping to anesthetize the area, presumably slow the circulation, take down the swelling.

The Peter Attia Drive
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

Sometimes trying to create a distraction. Okay. Okay. Sometimes, though, probably illogical trying to keep whatever humor is in there that's hurting isolated like a tourniquet. Right. Right. Obviously, if I'm using cold, especially if it's one of my kids that hurt themselves, we'll put cold on hoping to anesthetize the area, presumably slow the circulation, take down the swelling.