Dr. Peter Attia

That is not the case. I want to be clear. It might be that, and it likely is, in fact, it almost undoubtedly is, that smoking tobacco is a much higher level of risk. But I want to make sure people understand that if your nicotine is tobacco derived as opposed to synthetic, you are still probably assuming risk.

That is not the case. I want to be clear. It might be that, and it likely is, in fact, it almost undoubtedly is, that smoking tobacco is a much higher level of risk. But I want to make sure people understand that if your nicotine is tobacco derived as opposed to synthetic, you are still probably assuming risk.

So the level of these compounds depends on the processing technique and the tobacco variety, of course. So they're found in the highest concentrations in products that actually still look like tobacco. So I think that's kind of a nice way to think about it. Everybody can imagine what a cigarette looks like. If you take tobacco chewing leaves, people chew tobacco,

So the level of these compounds depends on the processing technique and the tobacco variety, of course. So they're found in the highest concentrations in products that actually still look like tobacco. So I think that's kind of a nice way to think about it. Everybody can imagine what a cigarette looks like. If you take tobacco chewing leaves, people chew tobacco,

that's going to have a lot of the negative properties. So the more closely you are to tobacco, the worse things are. So obviously if you're sticking it in a cigarette or a cigar or a pipe, yep, you're getting plenty of it there. If you're chewing it or taking it in snooze, also a big problem. So this is why I don't think I fully appreciated this four years ago.

that's going to have a lot of the negative properties. So the more closely you are to tobacco, the worse things are. So obviously if you're sticking it in a cigarette or a cigar or a pipe, yep, you're getting plenty of it there. If you're chewing it or taking it in snooze, also a big problem. So this is why I don't think I fully appreciated this four years ago.

When you take nicotine out of tobacco directly, you're still assuming some of that risk that comes in curing and fermentation of the tobacco itself.

When you take nicotine out of tobacco directly, you're still assuming some of that risk that comes in curing and fermentation of the tobacco itself.

Yeah, boy, that's okay. This is a philosophical issue. But as some people listening to this podcast know, I am an enormous fan of Formula One. And that goes way back for a long period of time. And up until 2005, tobacco was a major sponsor of Formula One. In fact, the largest sponsor would have been Marlboro. And they were in the early 2000s all over the Ferraris.

Yeah, boy, that's okay. This is a philosophical issue. But as some people listening to this podcast know, I am an enormous fan of Formula One. And that goes way back for a long period of time. And up until 2005, tobacco was a major sponsor of Formula One. In fact, the largest sponsor would have been Marlboro. And they were in the early 2000s all over the Ferraris.

And in the era that is my favorite era of Formula One in the 1980s and the early 90s, they were all over the McLaren car. And so you are correct. From time to time, you will see me wearing something or memorabilia that I have that is a throwback to that era of Formula One. And I believe in the original livery of those vehicles.

And in the era that is my favorite era of Formula One in the 1980s and the early 90s, they were all over the McLaren car. And so you are correct. From time to time, you will see me wearing something or memorabilia that I have that is a throwback to that era of Formula One. And I believe in the original livery of those vehicles.

In other words, I believe in era appropriate nods to things that we pay attention to. And so, yes, if you're looking at a hat or a shirt or a car that is a replica or pays homage to something of that era, you're going to see the livery of the sponsors of the time. And that would have been Hugo Boss, Nacional, Marlboro.

In other words, I believe in era appropriate nods to things that we pay attention to. And so, yes, if you're looking at a hat or a shirt or a car that is a replica or pays homage to something of that era, you're going to see the livery of the sponsors of the time. And that would have been Hugo Boss, Nacional, Marlboro.

Anyway, there's nothing else I can say about it other than it has nothing to do with a tacit or otherwise approval of these products. I want to be unambiguously clear. I think smoking is an absolute error, arguably the single biggest unforced error you can make with respect to your health. And fortunately, Big Tobacco does not sponsor motorsport anymore, and I think they're better for it. Perfect.

Anyway, there's nothing else I can say about it other than it has nothing to do with a tacit or otherwise approval of these products. I want to be unambiguously clear. I think smoking is an absolute error, arguably the single biggest unforced error you can make with respect to your health. And fortunately, Big Tobacco does not sponsor motorsport anymore, and I think they're better for it. Perfect.

Well, we're going to go into this in some detail, but I would say that clearly the biggest risk of pure nicotine, and now I'm just talking about it through the lens of synthetically acquired nicotine, so you're getting rid of all the tobacco-related processing, is in its addictive nature. And make no mistake about it, nicotine is highly addictive.

Well, we're going to go into this in some detail, but I would say that clearly the biggest risk of pure nicotine, and now I'm just talking about it through the lens of synthetically acquired nicotine, so you're getting rid of all the tobacco-related processing, is in its addictive nature. And make no mistake about it, nicotine is highly addictive.

There are some other areas where, depending on the dose, there may actually be a harm. Again, I think this is very important to understand. There are some mechanistic insights that suggest a negative impact on the endothelium. And it's certainly plausible that anything that negatively impacts the endothelium could increase the risk of cardiovascular disease. But these are not large studies.

There are some other areas where, depending on the dose, there may actually be a harm. Again, I think this is very important to understand. There are some mechanistic insights that suggest a negative impact on the endothelium. And it's certainly plausible that anything that negatively impacts the endothelium could increase the risk of cardiovascular disease. But these are not large studies.