Dr. Peter Attia

But you're going to start orally.

But you're going to start orally.

You're going to start at 100 milligrams, 50 milligrams.

You're going to start at 100 milligrams, 50 milligrams.

Do we believe that 100 systemically is sufficient to oppose estrogen?

Do we believe that 100 systemically is sufficient to oppose estrogen?

So the only thing that we do I would say different there is while we start women at 50 to 100, we will generally take them to 200 if tolerated, and if not, keep them where they are at 100. But we find women who are in that one-third to one-half group who are very positively selected towards progesterone, they feel fantastic at 200. The most notable improvement is sleep.

So the only thing that we do I would say different there is while we start women at 50 to 100, we will generally take them to 200 if tolerated, and if not, keep them where they are at 100. But we find women who are in that one-third to one-half group who are very positively selected towards progesterone, they feel fantastic at 200. The most notable improvement is sleep.

So would you agree with that? Totally agree. Most women are just over the moon with how well they sleep.

So would you agree with that? Totally agree. Most women are just over the moon with how well they sleep.

Hair gets thicker and mood improves. So now let's talk about the other subset of women. And this is a real subset.

Hair gets thicker and mood improves. So now let's talk about the other subset of women. And this is a real subset.

It's, I would say in our population, it's about 10 to 20% for whom if you bring progesterone in the room, something goes wrong. their mood really changes. Now, it can in some cases become depressive, but more commonly what they tell me is, and I'm quoting them, this is not me saying it, I become a raging bitch. I'm worried I might kill my husband.

It's, I would say in our population, it's about 10 to 20% for whom if you bring progesterone in the room, something goes wrong. their mood really changes. Now, it can in some cases become depressive, but more commonly what they tell me is, and I'm quoting them, this is not me saying it, I become a raging bitch. I'm worried I might kill my husband.

So for those women, we think progesterone's a bad idea. And we then use a progesterone-coated IUD. So are you doing that or are you using a suppository at that point?

So for those women, we think progesterone's a bad idea. And we then use a progesterone-coated IUD. So are you doing that or are you using a suppository at that point?

Are you referring women who are on what potentially might be a low dose of progesterone to their GYN for endometrial ultrasounds on some regular interval just to look for hyperplasia or anything like that?

Are you referring women who are on what potentially might be a low dose of progesterone to their GYN for endometrial ultrasounds on some regular interval just to look for hyperplasia or anything like that?

Okay. Anything else you want to say about progesterone? Do you start it concomitantly with the estrogen? Do you like to start one before the other?

Okay. Anything else you want to say about progesterone? Do you start it concomitantly with the estrogen? Do you like to start one before the other?