Dr. Rhonda Patrick

You've been talking a lot about proline, hydroxyproline, glycine.

I mean, these are amino acids that are certainly in greater quantity in something like hydrolyzed collagen powder versus a protein source from food or even a protein powder.

But there's been a lot of, at least a lot of preclinical evidence looking at

these small peptides being signaling molecules in their tissues.

And there's been a lot of sort of, I would say, speculation that perhaps the signaling role of these collagen peptides may be as important, if not more important, than the incorporation of proline and hydroxyproline and glycine into tendons and skin.

Yeah.

The thing that really piqued my interest in that was there's been a few studies looking at very small amounts of hydrolyzed collagen powder.

I mean, amounts that you would get in a pill in people with giving them either the hydrolyzed collagen powder or a placebo in people with arthritis.

And the very, very small amount of hydrolyzed collagen powder was having...

an effect on reducing, you know, some of their, a lot of it's subjective, but there was also some inflammation that was reduced.

That's why I brought up the signaling molecule as well, because when I saw the doses, and these are placebo-controlled, it was very surprising to me.

I'm like, well, it's got to be something else going on.

The last thing about the hydrolyzed collagen powder I wanted to talk about was getting your thoughts on, you know, so typically hydrolyzed collagen powder is available in a wide variety of sizes.

So anywhere between 2 kilodollars to 10.

And there's some evidence that suggests perhaps that smaller, like two to five kilodaltons, those peptides are better absorbed, better used as signaling molecules, getting to the tissues better.

Like, for example, skin, getting smaller ones like two to three kilodaltons.

I mean, again, there's not an overwhelming amount of evidence on this.

It's really up and coming, and I think in its infancy.

But I just wanted to get your thoughts and any speculation as to why smaller, perhaps not the 10 kilodaltons, but maybe the two to five range might be

And what are your thoughts on the skin studies?