Dr. Richard Johnson

Just to talk about Alzheimer's just for a few minutes, we talked about the focus being on amyloid plaques and tau protein. And in the very beginning, everyone said, well, maybe that's the cause of Alzheimer's, these plaques. And if we can figure out how to remove the plaques or to prevent the plaques, we can treat the disease.

Just to talk about Alzheimer's just for a few minutes, we talked about the focus being on amyloid plaques and tau protein. And in the very beginning, everyone said, well, maybe that's the cause of Alzheimer's, these plaques. And if we can figure out how to remove the plaques or to prevent the plaques, we can treat the disease.

Just to talk about Alzheimer's just for a few minutes, we talked about the focus being on amyloid plaques and tau protein. And in the very beginning, everyone said, well, maybe that's the cause of Alzheimer's, these plaques. And if we can figure out how to remove the plaques or to prevent the plaques, we can treat the disease.

And so much of the focus of the big pharma has been to try to develop ways to block that. And as you have already mentioned, you know, there's been like 40 different drugs that have gone to trial and only a few have succeeded and they only work partially at best. And so people said, you know, there must be something that starts this whole disease.

And so much of the focus of the big pharma has been to try to develop ways to block that. And as you have already mentioned, you know, there's been like 40 different drugs that have gone to trial and only a few have succeeded and they only work partially at best. And so people said, you know, there must be something that starts this whole disease.

And so much of the focus of the big pharma has been to try to develop ways to block that. And as you have already mentioned, you know, there's been like 40 different drugs that have gone to trial and only a few have succeeded and they only work partially at best. And so people said, you know, there must be something that starts this whole disease.

Let's, you know, let's go back to when the disease is just beginning. Can we actually identify, you know, factors that seem to be important? And some of the factors that were important, you know, it's associated with diabetes and obesity, and these are diseases that I study. So I was interested in that. And it's also associated with insulin resistance in the brain.

Let's, you know, let's go back to when the disease is just beginning. Can we actually identify, you know, factors that seem to be important? And some of the factors that were important, you know, it's associated with diabetes and obesity, and these are diseases that I study. So I was interested in that. And it's also associated with insulin resistance in the brain.

Let's, you know, let's go back to when the disease is just beginning. Can we actually identify, you know, factors that seem to be important? And some of the factors that were important, you know, it's associated with diabetes and obesity, and these are diseases that I study. So I was interested in that. And it's also associated with insulin resistance in the brain.

And they do these studies where they can show that there's an impairment of glucose being taken up in the brain. If you do special scans, you can show that there's an impairment in the ability for the brain to take up glucose. It's like the brain is becoming insulin resistant.

And they do these studies where they can show that there's an impairment of glucose being taken up in the brain. If you do special scans, you can show that there's an impairment in the ability for the brain to take up glucose. It's like the brain is becoming insulin resistant.

And they do these studies where they can show that there's an impairment of glucose being taken up in the brain. If you do special scans, you can show that there's an impairment in the ability for the brain to take up glucose. It's like the brain is becoming insulin resistant.

Okay, so the brain uses glucose as its primary fuel and it loves glucose. Glucose is the main carbohydrate that's circulating in our blood. If our glucose levels are high, we call it diabetes. If the glucose levels are low, we call it hypoglycemia. But glucose is like the primary fuel and it's a major fuel the brain uses.

Okay, so the brain uses glucose as its primary fuel and it loves glucose. Glucose is the main carbohydrate that's circulating in our blood. If our glucose levels are high, we call it diabetes. If the glucose levels are low, we call it hypoglycemia. But glucose is like the primary fuel and it's a major fuel the brain uses.

Okay, so the brain uses glucose as its primary fuel and it loves glucose. Glucose is the main carbohydrate that's circulating in our blood. If our glucose levels are high, we call it diabetes. If the glucose levels are low, we call it hypoglycemia. But glucose is like the primary fuel and it's a major fuel the brain uses.

But in early Alzheimer's, there seems to be an impairment in the neurons being able to utilize the glucose. So insulin is a hormone that helps drive glucose into cells. if you become insulin resistant, you have trouble getting glucose into those cells. A lot of the brain, it doesn't require much insulin at all, and glucose can go in pretty easily.

But in early Alzheimer's, there seems to be an impairment in the neurons being able to utilize the glucose. So insulin is a hormone that helps drive glucose into cells. if you become insulin resistant, you have trouble getting glucose into those cells. A lot of the brain, it doesn't require much insulin at all, and glucose can go in pretty easily.

But in early Alzheimer's, there seems to be an impairment in the neurons being able to utilize the glucose. So insulin is a hormone that helps drive glucose into cells. if you become insulin resistant, you have trouble getting glucose into those cells. A lot of the brain, it doesn't require much insulin at all, and glucose can go in pretty easily.

But there are certain regions of the brain that are insulin sensitive, and those parts of the brain, if you become insulin resistant, you can't deliver the fuel as well. And that's associated with the second problem that you see in Alzheimer's, which is the the mitochondria are these little factories in the cell that make energy. They make ATP.

But there are certain regions of the brain that are insulin sensitive, and those parts of the brain, if you become insulin resistant, you can't deliver the fuel as well. And that's associated with the second problem that you see in Alzheimer's, which is the the mitochondria are these little factories in the cell that make energy. They make ATP.