Dr. Richard Johnson

But there are certain regions of the brain that are insulin sensitive, and those parts of the brain, if you become insulin resistant, you can't deliver the fuel as well. And that's associated with the second problem that you see in Alzheimer's, which is the the mitochondria are these little factories in the cell that make energy. They make ATP.

And there seems to be some problems with these energy factories in early Alzheimer's. They're not making as much ATP as they should. There's seems to be some stress going on with the mitochondria over time. There can be a loss of mitochondria. And so you have a problem with the energy factories, you have a problem with them taking up glucose to make energy, and you have low grade inflammation.

And there seems to be some problems with these energy factories in early Alzheimer's. They're not making as much ATP as they should. There's seems to be some stress going on with the mitochondria over time. There can be a loss of mitochondria. And so you have a problem with the energy factories, you have a problem with them taking up glucose to make energy, and you have low grade inflammation.

And there seems to be some problems with these energy factories in early Alzheimer's. They're not making as much ATP as they should. There's seems to be some stress going on with the mitochondria over time. There can be a loss of mitochondria. And so you have a problem with the energy factories, you have a problem with them taking up glucose to make energy, and you have low grade inflammation.

And I thought to myself, you know, this is actually what I study, but not in the brain, but what I'm studying in the circulation, what I'm studying in the systemic systems. You know, I'm looking at what drives insulin resistance, and I have personally linked it with energy production and inability for these energy factories to make ATP. And I thought, oh my gosh, there's a connection there.

And I thought to myself, you know, this is actually what I study, but not in the brain, but what I'm studying in the circulation, what I'm studying in the systemic systems. You know, I'm looking at what drives insulin resistance, and I have personally linked it with energy production and inability for these energy factories to make ATP. And I thought, oh my gosh, there's a connection there.

And I thought to myself, you know, this is actually what I study, but not in the brain, but what I'm studying in the circulation, what I'm studying in the systemic systems. You know, I'm looking at what drives insulin resistance, and I have personally linked it with energy production and inability for these energy factories to make ATP. And I thought, oh my gosh, there's a connection there.

And some people call early Alzheimer's brain diabetes because of this insulin resistance. And so I knew that there had to be some kind of link between those two diseases. you know, between obesity and diabetes. And people who are obese and diabetic have an increased risk for developing it.

And some people call early Alzheimer's brain diabetes because of this insulin resistance. And so I knew that there had to be some kind of link between those two diseases. you know, between obesity and diabetes. And people who are obese and diabetic have an increased risk for developing it.

And some people call early Alzheimer's brain diabetes because of this insulin resistance. And so I knew that there had to be some kind of link between those two diseases. you know, between obesity and diabetes. And people who are obese and diabetic have an increased risk for developing it.

But there seem to, it isn't a match, you know, it isn't like if you're overweight, you're going to get dementia. But there is this association. A strong correlation. Yeah, a correlation. And so I started thinking,

But there seem to, it isn't a match, you know, it isn't like if you're overweight, you're going to get dementia. But there is this association. A strong correlation. Yeah, a correlation. And so I started thinking,

But there seem to, it isn't a match, you know, it isn't like if you're overweight, you're going to get dementia. But there is this association. A strong correlation. Yeah, a correlation. And so I started thinking,

thinking about what our work shows in the body and I started thinking about how that system might work on the brain and I had this kind of aha moment where I suddenly realized that I could explain how Alzheimer's develops.

thinking about what our work shows in the body and I started thinking about how that system might work on the brain and I had this kind of aha moment where I suddenly realized that I could explain how Alzheimer's develops.

thinking about what our work shows in the body and I started thinking about how that system might work on the brain and I had this kind of aha moment where I suddenly realized that I could explain how Alzheimer's develops.

So everybody who's looking at me, please don't, you know, it's not like I'm saying this is the cause, but I would like to present you the evidence because it's very strong.

So everybody who's looking at me, please don't, you know, it's not like I'm saying this is the cause, but I would like to present you the evidence because it's very strong.

So everybody who's looking at me, please don't, you know, it's not like I'm saying this is the cause, but I would like to present you the evidence because it's very strong.

Exactly. And so just like currently, there are different groups that are saying, okay, they've got insulin resistance in the brain. How about if we give insulin through the nose, through the nostrils, where it can actually get to the brain directly? And can we treat the disease? Can we improve things? And there are early studies saying that might help a little bit.