Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Pricing

Dr. Richard Johnson

👤 Person
456 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

All these things. All these things we get in the grocery store. So first off, there's this association of foods that can make fructose or that contain fructose. Correlate, you know, and I don't mean natural fruits. I mean like soft drinks and fruit juice. You know, these things are associated with Alzheimer's.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

All these things. All these things we get in the grocery store. So first off, there's this association of foods that can make fructose or that contain fructose. Correlate, you know, and I don't mean natural fruits. I mean like soft drinks and fruit juice. You know, these things are associated with Alzheimer's.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Obesity is associated with Alzheimer's. Diabetes is. And these are conditions associated with, you know, that we think fructose is driving. Okay. So then, so that's the first thing is there's this association. Then the second thing is that if you give sugar to an animal, after a number of weeks, they actually have trouble going through a maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Obesity is associated with Alzheimer's. Diabetes is. And these are conditions associated with, you know, that we think fructose is driving. Okay. So then, so that's the first thing is there's this association. Then the second thing is that if you give sugar to an animal, after a number of weeks, they actually have trouble going through a maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Obesity is associated with Alzheimer's. Diabetes is. And these are conditions associated with, you know, that we think fructose is driving. Okay. So then, so that's the first thing is there's this association. Then the second thing is that if you give sugar to an animal, after a number of weeks, they actually have trouble going through a maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So normally you can measure how long it takes for a lab mouse to get through a maze. And each time it will get a little bit smarter and it'll shorten the amount of time to get through it. But if you feed it sugar, it doesn't show that shortening. It continues to have trouble all the time getting through the maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So normally you can measure how long it takes for a lab mouse to get through a maze. And each time it will get a little bit smarter and it'll shorten the amount of time to get through it. But if you feed it sugar, it doesn't show that shortening. It continues to have trouble all the time getting through the maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So normally you can measure how long it takes for a lab mouse to get through a maze. And each time it will get a little bit smarter and it'll shorten the amount of time to get through it. But if you feed it sugar, it doesn't show that shortening. It continues to have trouble all the time getting through the maze.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And when you give the sugar to the animal and you look in the brain, guess what you find? You find suppression of the mitochondria with less, you know, there's oxidative stress to the mitochondria, which we know happens in other tissues with fructose. And it's associated with lower ATP production, low-grade inflammation, and insulin resistance. That is the hallmark of early Alzheimer's. Right.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And when you give the sugar to the animal and you look in the brain, guess what you find? You find suppression of the mitochondria with less, you know, there's oxidative stress to the mitochondria, which we know happens in other tissues with fructose. And it's associated with lower ATP production, low-grade inflammation, and insulin resistance. That is the hallmark of early Alzheimer's. Right.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And when you give the sugar to the animal and you look in the brain, guess what you find? You find suppression of the mitochondria with less, you know, there's oxidative stress to the mitochondria, which we know happens in other tissues with fructose. And it's associated with lower ATP production, low-grade inflammation, and insulin resistance. That is the hallmark of early Alzheimer's. Right.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

I mean, these are the exact same things. You can show exactly the same things. And then over time, if you take the animals out to like 18 weeks and you then you start seeing the amyloid plaques as well as tau protein in the brains of those mice. Wow. So that's pretty strong evidence. Okay.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

I mean, these are the exact same things. You can show exactly the same things. And then over time, if you take the animals out to like 18 weeks and you then you start seeing the amyloid plaques as well as tau protein in the brains of those mice. Wow. So that's pretty strong evidence. Okay.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

I mean, these are the exact same things. You can show exactly the same things. And then over time, if you take the animals out to like 18 weeks and you then you start seeing the amyloid plaques as well as tau protein in the brains of those mice. Wow. So that's pretty strong evidence. Okay.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

They call it an Alzheimer's model, but it's, yeah, exactly. Just fructose in the drinking.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

They call it an Alzheimer's model, but it's, yeah, exactly. Just fructose in the drinking.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

They call it an Alzheimer's model, but it's, yeah, exactly. Just fructose in the drinking.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Now, here's another bit of evidence. If you take people with early Alzheimer's, and there was an autopsy study done, In early Alzheimer's, they had like nine subjects, and all nine had fructose levels in the brain five-fold higher than the controls, than the control autopsy brains. There was five times more fructose.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Now, here's another bit of evidence. If you take people with early Alzheimer's, and there was an autopsy study done, In early Alzheimer's, they had like nine subjects, and all nine had fructose levels in the brain five-fold higher than the controls, than the control autopsy brains. There was five times more fructose.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Now, here's another bit of evidence. If you take people with early Alzheimer's, and there was an autopsy study done, In early Alzheimer's, they had like nine subjects, and all nine had fructose levels in the brain five-fold higher than the controls, than the control autopsy brains. There was five times more fructose.