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Dr. Richard Johnson

👤 Person
456 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

It increases pressure in the kidneys to facilitate excretion of the stuff through the kidneys. It causes insulin resistance, which is to help preserve some glucose in the blood for tissues that need it. It makes fat, but it blocks the breaking down of fat. And so it's stimulating all of these at once, and it's all working together.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

It increases pressure in the kidneys to facilitate excretion of the stuff through the kidneys. It causes insulin resistance, which is to help preserve some glucose in the blood for tissues that need it. It makes fat, but it blocks the breaking down of fat. And so it's stimulating all of these at once, and it's all working together.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

It increases pressure in the kidneys to facilitate excretion of the stuff through the kidneys. It causes insulin resistance, which is to help preserve some glucose in the blood for tissues that need it. It makes fat, but it blocks the breaking down of fat. And so it's stimulating all of these at once, and it's all working together.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Through the mitochondria, there's specific chemical pathways that are driving each one that we've been studying. So we can actually show how the insulin resistance develops, why you can't break down the fat. It's all driven through this this particular chemistry. And then we realized that fructose was meant to help us store energy and prepare us for times when there's no food around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Through the mitochondria, there's specific chemical pathways that are driving each one that we've been studying. So we can actually show how the insulin resistance develops, why you can't break down the fat. It's all driven through this this particular chemistry. And then we realized that fructose was meant to help us store energy and prepare us for times when there's no food around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Through the mitochondria, there's specific chemical pathways that are driving each one that we've been studying. So we can actually show how the insulin resistance develops, why you can't break down the fat. It's all driven through this this particular chemistry. And then we realized that fructose was meant to help us store energy and prepare us for times when there's no food around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Yes. whereas glucose is therefore the immediate fuel and then glucose is like trying to raise the atp in the cell fructose is trying to get us to store fat and the way it does it is it drops it stuns the mitochondria drops that atp and activates all those pathways and that was the fundamental discovery we go oh my gosh this is super important in evolution in biology glucose is really meant

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Yes. whereas glucose is therefore the immediate fuel and then glucose is like trying to raise the atp in the cell fructose is trying to get us to store fat and the way it does it is it drops it stuns the mitochondria drops that atp and activates all those pathways and that was the fundamental discovery we go oh my gosh this is super important in evolution in biology glucose is really meant

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

Yes. whereas glucose is therefore the immediate fuel and then glucose is like trying to raise the atp in the cell fructose is trying to get us to store fat and the way it does it is it drops it stuns the mitochondria drops that atp and activates all those pathways and that was the fundamental discovery we go oh my gosh this is super important in evolution in biology glucose is really meant

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

has a different role than fructose. And then we realized, though, that if you eat too much glucose, it gets turned over into fructose. And we found out that very mild dehydration could also stimulate fructose production because fructose helps the animal store water by generating fat. And then we realized that the best way to create an animal to cause mild dehydration was to eat salt.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

has a different role than fructose. And then we realized, though, that if you eat too much glucose, it gets turned over into fructose. And we found out that very mild dehydration could also stimulate fructose production because fructose helps the animal store water by generating fat. And then we realized that the best way to create an animal to cause mild dehydration was to eat salt.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

has a different role than fructose. And then we realized, though, that if you eat too much glucose, it gets turned over into fructose. And we found out that very mild dehydration could also stimulate fructose production because fructose helps the animal store water by generating fat. And then we realized that the best way to create an animal to cause mild dehydration was to eat salt.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And then we started doing studies with salt and we realized that when you eat salt and you get thirsty, you're actually stimulating fructose production from glucose. So salt activates the chemical reaction that converts glucose to fructose. So you've got two things that are important for making fructose. One is you gotta have glucose around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And then we started doing studies with salt and we realized that when you eat salt and you get thirsty, you're actually stimulating fructose production from glucose. So salt activates the chemical reaction that converts glucose to fructose. So you've got two things that are important for making fructose. One is you gotta have glucose around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

And then we started doing studies with salt and we realized that when you eat salt and you get thirsty, you're actually stimulating fructose production from glucose. So salt activates the chemical reaction that converts glucose to fructose. So you've got two things that are important for making fructose. One is you gotta have glucose around.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So if you're on a low carb diet, you're in good shape because you're not going to have so much glucose around because all glucose comes from, you know, the main source of glucose in our body comes from the carbs. You can make glucose from amino acids and so forth, but it's not very much. And so most of the glucose that we in our body comes from the carbs.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So if you're on a low carb diet, you're in good shape because you're not going to have so much glucose around because all glucose comes from, you know, the main source of glucose in our body comes from the carbs. You can make glucose from amino acids and so forth, but it's not very much. And so most of the glucose that we in our body comes from the carbs.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So if you're on a low carb diet, you're in good shape because you're not going to have so much glucose around because all glucose comes from, you know, the main source of glucose in our body comes from the carbs. You can make glucose from amino acids and so forth, but it's not very much. And so most of the glucose that we in our body comes from the carbs.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So if you're on a low carb diet, you're not going to make very much fructose. That's why low carb diets are so fantastic because not only are they reducing sugar intake, but they're reducing carb intake that will reduce the amount of fructose you make. But salt is a very powerful way of converting glucose to fructose.

Dhru Purohit Show
Why Excess Added Sugar is Driving Modern Diseases and How to Take Back Our Metabolic Health and Overcome a Sedentary Lifestyle

So if you're on a low carb diet, you're not going to make very much fructose. That's why low carb diets are so fantastic because not only are they reducing sugar intake, but they're reducing carb intake that will reduce the amount of fructose you make. But salt is a very powerful way of converting glucose to fructose.