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Dr. Richard Moulange

πŸ‘€ Speaker
1784 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

But you could test how well the viruses are killing the bacteria.

242.594 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And some of the best ones do better than the best existing bacteriophage we'd ever found before.

245.679 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

This is huge.

252.397 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

We can now design organisms, small ones, to do things better than we have ever seen in nature.

253.859 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

We can go beyond nature in this very narrow subdomain of biology.

260.25 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And this heralds the promise of genome scale engineering, which is going to be, I think, a revolutionary capability within biology.

264.938 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

At the end of last year, there was a great paper from the AI red teamers at Microsoft, Whitman et al.

284.315 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And it's recently published in Science.

291.045 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And what they showed is that you can take

293.729 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Current, off-the-shelf, open-weight biological tools.

296.828 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So not necessarily these language models.

301.314 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

They might be sort of more specialized, a bit how AlphaFold is specialized for predicting protein structure, but it can't do every single biological task under the sun.

302.835 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And they took ones that are instead good at generating protein sequences in particular and designing proteins.

311.366 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

What they did is they made lots of designs for ricin.

317.922 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

So ricin is, it's actually sort of two different proteins together in what's called a complex.

322.235 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

And it's a known chemical weapon.

328.454 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Essentially, yes, ricin can be considered either as a chemical weapon or a biological weapon.

332.3 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

Yes.

339.817 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

You can derive it from living organisms.

340.559 View full episode β†’
80,000 Hours Podcast
AI designs genomes from scratch & outperforms virologists at lab work. What could go wrong? | Dr Richard Moulange, CLTR

I'm not going to discuss in depth how you can do that.

342.864 View full episode β†’