Dr. Robert Turesky

Some people will detoxify the carcinogen more efficiently than others. And so we have these chemical biomarkers in urine. We can say, yeah, well, person A is more efficiently in converting this to a hazardous metabolite than person B. And so that's some of our long-term goals.

Some people will detoxify the carcinogen more efficiently than others. And so we have these chemical biomarkers in urine. We can say, yeah, well, person A is more efficiently in converting this to a hazardous metabolite than person B. And so that's some of our long-term goals.

I mean, we have an understanding of how these chemicals that I'm interested in, how they're metabolized in, we've done studies which were dominantly with Caucasians because we didn't have an African-American cohort.

I mean, we have an understanding of how these chemicals that I'm interested in, how they're metabolized in, we've done studies which were dominantly with Caucasians because we didn't have an African-American cohort.

But for instance, the studies that we're doing with Clarence now, if our data holds up and we do see that, yeah, African-American men have higher levels of this potential cancer-causing agent in their hair, we don't understand whether there's a difference in how African-American men or white men process carcinogens. One way we could do it is we can identify

But for instance, the studies that we're doing with Clarence now, if our data holds up and we do see that, yeah, African-American men have higher levels of this potential cancer-causing agent in their hair, we don't understand whether there's a difference in how African-American men or white men process carcinogens. One way we could do it is we can identify

men who have high levels of this in their hair. We could measure the amounts of this carcinogen in the cooked meat. We can collect urine over the 24 hour period after they ate the meat. And we can see how they transform this chemical by looking at the metabolites in urine.

men who have high levels of this in their hair. We could measure the amounts of this carcinogen in the cooked meat. We can collect urine over the 24 hour period after they ate the meat. And we can see how they transform this chemical by looking at the metabolites in urine.

And we can compare those to say white men and understand that there's a difference in how the two different races metabolize this compound. And that could also perhaps help to explain elevated risk in one cohort versus the other. This is all stuff that we would like to do. We just need to get funded to do it.

And we can compare those to say white men and understand that there's a difference in how the two different races metabolize this compound. And that could also perhaps help to explain elevated risk in one cohort versus the other. This is all stuff that we would like to do. We just need to get funded to do it.

I'm sorry. Clarence, is he being cut off? Were you able to hear him? Yep, yep, we got him. I just, I... I'm being cut off with some of the audio.

I'm sorry. Clarence, is he being cut off? Were you able to hear him? Yep, yep, we got him. I just, I... I'm being cut off with some of the audio.

Right. Well, again, so the end point that we're looking at, we're very excited about because it suggests a lifestyle factor. meaning eating well-done cooked meat, and I underscore may, may be contributing to prostate cancer risk and may, underscore, contribute to an elevated risk for African-American men.

Right. Well, again, so the end point that we're looking at, we're very excited about because it suggests a lifestyle factor. meaning eating well-done cooked meat, and I underscore may, may be contributing to prostate cancer risk and may, underscore, contribute to an elevated risk for African-American men.

So what I try to convey, you know, when I have to give talks, and most of the time I give to a scientific audience, okay, so I can use a lot of technical jargon, but when I'm speaking to the public, I tell them, if you don't understand anything that I'm talking about, if there's one message or two messages to take home is one, don't burn your meat, right?

So what I try to convey, you know, when I have to give talks, and most of the time I give to a scientific audience, okay, so I can use a lot of technical jargon, but when I'm speaking to the public, I tell them, if you don't understand anything that I'm talking about, if there's one message or two messages to take home is one, don't burn your meat, right?

It's when you really char your meats that you're increasing the levels of this cancer causing agent. All right. So, you know, I don't eat my meats well done anymore. I try to eat the medium to medium rare. Uh, and, um, first of all, it's a lot healthier for you. A lot of the nutrients and the essential amino acids are present in a higher amount of meat than the non-food well done.

It's when you really char your meats that you're increasing the levels of this cancer causing agent. All right. So, you know, I don't eat my meats well done anymore. I try to eat the medium to medium rare. Uh, and, um, first of all, it's a lot healthier for you. A lot of the nutrients and the essential amino acids are present in a higher amount of meat than the non-food well done.

And you form a lot less of this cancer-causing agent. So already, if you can just do that, minimize the charring in eating meat well done, you've already done something that's positive, right? And as I said earlier, It's all about the dose. So, I mean, it's not healthy to eat well-done cooked meats or grilled bacon, crispy grilled bacon every day. I mean, moderate your diet.

And you form a lot less of this cancer-causing agent. So already, if you can just do that, minimize the charring in eating meat well done, you've already done something that's positive, right? And as I said earlier, It's all about the dose. So, I mean, it's not healthy to eat well-done cooked meats or grilled bacon, crispy grilled bacon every day. I mean, moderate your diet.