Dr. Rocio Salas-Whalen
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Podcast Appearances
Glucagon-like peptide. And it's a peptide or a hormone.
Glucagon-like peptide. And it's a peptide or a hormone.
No, peptide is... what we call a short chain of amino acids. A long chain of amino acid is a protein. So before protein, it's a peptide. Peptides can help to produce or inhibit the secretion of hormones. The most important finding of this drug, and I actually met the person, the doctor, the researcher who isolated this, the GLP-1 outside the human body. It was in a lizard.
No, peptide is... what we call a short chain of amino acids. A long chain of amino acid is a protein. So before protein, it's a peptide. Peptides can help to produce or inhibit the secretion of hormones. The most important finding of this drug, and I actually met the person, the doctor, the researcher who isolated this, the GLP-1 outside the human body. It was in a lizard.
No, peptide is... what we call a short chain of amino acids. A long chain of amino acid is a protein. So before protein, it's a peptide. Peptides can help to produce or inhibit the secretion of hormones. The most important finding of this drug, and I actually met the person, the doctor, the researcher who isolated this, the GLP-1 outside the human body. It was in a lizard.
called the Gila monster. And the lizard, the venom of this lizard, caused pancreatitis on its victims. So Dr. Eng, John Eng, being an endocrinologist and researcher at the VA hospital in the Bronx, wondered what in the venom affected the pancreas. And he isolated GLP-1.
called the Gila monster. And the lizard, the venom of this lizard, caused pancreatitis on its victims. So Dr. Eng, John Eng, being an endocrinologist and researcher at the VA hospital in the Bronx, wondered what in the venom affected the pancreas. And he isolated GLP-1.
called the Gila monster. And the lizard, the venom of this lizard, caused pancreatitis on its victims. So Dr. Eng, John Eng, being an endocrinologist and researcher at the VA hospital in the Bronx, wondered what in the venom affected the pancreas. And he isolated GLP-1.
It causes pancreatitis, so the prey dies from pancreatitis.
It causes pancreatitis, so the prey dies from pancreatitis.
It causes pancreatitis, so the prey dies from pancreatitis.
So it stimulates to produce insulin. The problem in type 2 diabetes is insulin-resistant and hyperinsulinemia. So with time, with frequent stimulation of the pancreas, every time you eat, every time you eat anything that has glucose, your pancreas produces insulin. But with time, it overworks. Your body stops responding the same way to the insulin that you make.
So it stimulates to produce insulin. The problem in type 2 diabetes is insulin-resistant and hyperinsulinemia. So with time, with frequent stimulation of the pancreas, every time you eat, every time you eat anything that has glucose, your pancreas produces insulin. But with time, it overworks. Your body stops responding the same way to the insulin that you make.
So it stimulates to produce insulin. The problem in type 2 diabetes is insulin-resistant and hyperinsulinemia. So with time, with frequent stimulation of the pancreas, every time you eat, every time you eat anything that has glucose, your pancreas produces insulin. But with time, it overworks. Your body stops responding the same way to the insulin that you make.
So you become resistant to your own insulin. The pancreas in response tries to overcompensate and make more insulin overworked. but your body is resistant to it. So you have hyperinsulinemia and insulin resistance. So these are the two main pathologic factors that lead to somebody to develop type 2 diabetes.
So you become resistant to your own insulin. The pancreas in response tries to overcompensate and make more insulin overworked. but your body is resistant to it. So you have hyperinsulinemia and insulin resistance. So these are the two main pathologic factors that lead to somebody to develop type 2 diabetes.
So you become resistant to your own insulin. The pancreas in response tries to overcompensate and make more insulin overworked. but your body is resistant to it. So you have hyperinsulinemia and insulin resistance. So these are the two main pathologic factors that lead to somebody to develop type 2 diabetes.
And this is the beauty of medicine, right? One thing is made or developed for a particular disease or reason. We find out later that it has other benefits like GLP-1.
And this is the beauty of medicine, right? One thing is made or developed for a particular disease or reason. We find out later that it has other benefits like GLP-1.
And this is the beauty of medicine, right? One thing is made or developed for a particular disease or reason. We find out later that it has other benefits like GLP-1.