Dr. Scott Sherr

So you have your GABA-A receptor and you have your GABA-B receptor. And the GABA-A has all these subunits that other kinds of compounds can bind to that help the GABA itself bind to its site on the receptor. And then you have the GABA-B receptor as well, which is this G protein coupler receptor a little bit different.

Well, the thing about what happens is that alcohol binds very tightly to the GABA receptor, to the site where it binds on the receptor, which is again, this allosteric site, so not where GABA binds, but it increases the affinity for GABA to bind, but it does this in a very strong way.

Well, the thing about what happens is that alcohol binds very tightly to the GABA receptor, to the site where it binds on the receptor, which is again, this allosteric site, so not where GABA binds, but it increases the affinity for GABA to bind, but it does this in a very strong way.

Well, the thing about what happens is that alcohol binds very tightly to the GABA receptor, to the site where it binds on the receptor, which is again, this allosteric site, so not where GABA binds, but it increases the affinity for GABA to bind, but it does this in a very strong way.

And as a result of that, you have this strong binding of alcohol to the receptor, you have this strong affinity for GABA to bind, And what happens over time very quickly is that your body tries to compensate for this. And this is why you have tolerance. Eventually you have withdrawal when it comes to alcohol as well.

And as a result of that, you have this strong binding of alcohol to the receptor, you have this strong affinity for GABA to bind, And what happens over time very quickly is that your body tries to compensate for this. And this is why you have tolerance. Eventually you have withdrawal when it comes to alcohol as well.

And as a result of that, you have this strong binding of alcohol to the receptor, you have this strong affinity for GABA to bind, And what happens over time very quickly is that your body tries to compensate for this. And this is why you have tolerance. Eventually you have withdrawal when it comes to alcohol as well.

But the tolerance part is because with alcohol binds so tightly, it starts depleting GABA very quickly. And when you start depleting GABA, the body tries to compensate that for decreasing the number of GABA receptors available and also decreasing the number of GABA sites that you have available on the GABA receptor. And so as a result of that, you need more of the alcohol to get the same effect.

But the tolerance part is because with alcohol binds so tightly, it starts depleting GABA very quickly. And when you start depleting GABA, the body tries to compensate that for decreasing the number of GABA receptors available and also decreasing the number of GABA sites that you have available on the GABA receptor. And so as a result of that, you need more of the alcohol to get the same effect.

But the tolerance part is because with alcohol binds so tightly, it starts depleting GABA very quickly. And when you start depleting GABA, the body tries to compensate that for decreasing the number of GABA receptors available and also decreasing the number of GABA sites that you have available on the GABA receptor. And so as a result of that, you need more of the alcohol to get the same effect.

The other problem with alcohol, John, is that binds very quickly and tightly, but then it unbinds very quickly as well. And so this is why if you drink alcohol before you go to bed, you wake up, most people wake up like two or three hours later and they feel like wide awake or they feel terrible. This is how I used to feel when I was a kid and drinking alcohol.

The other problem with alcohol, John, is that binds very quickly and tightly, but then it unbinds very quickly as well. And so this is why if you drink alcohol before you go to bed, you wake up, most people wake up like two or three hours later and they feel like wide awake or they feel terrible. This is how I used to feel when I was a kid and drinking alcohol.

The other problem with alcohol, John, is that binds very quickly and tightly, but then it unbinds very quickly as well. And so this is why if you drink alcohol before you go to bed, you wake up, most people wake up like two or three hours later and they feel like wide awake or they feel terrible. This is how I used to feel when I was a kid and drinking alcohol.

I could wake up two or three hours later with the worst headache ever. Why is that? because now you've all of a sudden had this overabundance of glutamate as well, because you've screwed up the balance between the two of them.

I could wake up two or three hours later with the worst headache ever. Why is that? because now you've all of a sudden had this overabundance of glutamate as well, because you've screwed up the balance between the two of them.

I could wake up two or three hours later with the worst headache ever. Why is that? because now you've all of a sudden had this overabundance of glutamate as well, because you've screwed up the balance between the two of them.

And so that GABA unbinds very quickly, the GABA gets depleted, and then all of a sudden you have all this glutamate around and then you feel terrible, you get headaches, you get irritable, all those things.

And so that GABA unbinds very quickly, the GABA gets depleted, and then all of a sudden you have all this glutamate around and then you feel terrible, you get headaches, you get irritable, all those things.

And so that GABA unbinds very quickly, the GABA gets depleted, and then all of a sudden you have all this glutamate around and then you feel terrible, you get headaches, you get irritable, all those things.

And so that's why alcohol is terrible for people who wanna, in general, alcohol is not very good for a lot of different reasons, but for sleep, it's very bad because it really affects the whole aspect of you trying to, it may help you fall asleep, But it will not help you stay asleep and you will not get good sleep if you drink alcohol.