Dr. Scott Sherr

Yeah. So first question about like mitophagy, there are some small studies in animals that show that methylene blue does improve mitochondrial function on its own. So not only can it compensate for mitochondrial dysfunction, but it can actually rebuild part of the electron transport chain, specifically complex four or cytochrome oxidase and help rebuild and reboot the mitochondria itself.

Yeah. So first question about like mitophagy, there are some small studies in animals that show that methylene blue does improve mitochondrial function on its own. So not only can it compensate for mitochondrial dysfunction, but it can actually rebuild part of the electron transport chain, specifically complex four or cytochrome oxidase and help rebuild and reboot the mitochondria itself.

There's also some evidence that it does cause mitochondrial biogenesis as well. Really? And the reason for that, I think, is that because it's making the cells more efficient overall and there's more energy available as a result of that so that the cells make more mitochondria to actually... compensate for that or to build up a balance as a result.

There's also some evidence that it does cause mitochondrial biogenesis as well. Really? And the reason for that, I think, is that because it's making the cells more efficient overall and there's more energy available as a result of that so that the cells make more mitochondria to actually... compensate for that or to build up a balance as a result.

So these are preclinical, so it's hard to know overall. There's really no studies in mitophagy specifically that I've seen, but there is the sense that I have overall that you're just rebooting mitochondrial function. And so as a result of that, sometimes what's going to happen when you need to do that is actually you need to kill off mitochondria to start to make new ones, right?

So these are preclinical, so it's hard to know overall. There's really no studies in mitophagy specifically that I've seen, but there is the sense that I have overall that you're just rebooting mitochondrial function. And so as a result of that, sometimes what's going to happen when you need to do that is actually you need to kill off mitochondria to start to make new ones, right?

And so I think some of that is happening. I have seen, as I think about it now, there has been some literature on mitophagy in Alzheimer's models overall and how the methylene blue might be able to do this. And it's actually interesting how it might be able to do this.

And so I think some of that is happening. I have seen, as I think about it now, there has been some literature on mitophagy in Alzheimer's models overall and how the methylene blue might be able to do this. And it's actually interesting how it might be able to do this.

And this is kind of technical, but the low doses of methylene blue, the four milligrams, eight, 16, 20, those are really supportive to the mitochondria, okay? But higher doses like your 70s, 80s, 100s, things like that, they're also supportive, but they also stress the mitochondria at the same time. And they do that by creating hydrogen peroxide.

And this is kind of technical, but the low doses of methylene blue, the four milligrams, eight, 16, 20, those are really supportive to the mitochondria, okay? But higher doses like your 70s, 80s, 100s, things like that, they're also supportive, but they also stress the mitochondria at the same time. And they do that by creating hydrogen peroxide.

And so our cells have this capacity to make hydrogen peroxide. And they do this because it's a signaling molecule in the cell. And it's also something that's an anti-infective. So the cell will make or release actually hydrogen peroxide when there's a bug around that they're trying to kill. And that comes from the part of the cell called the lysosome.

And so our cells have this capacity to make hydrogen peroxide. And they do this because it's a signaling molecule in the cell. And it's also something that's an anti-infective. So the cell will make or release actually hydrogen peroxide when there's a bug around that they're trying to kill. And that comes from the part of the cell called the lysosome.

And so what methylene blue does is increase the amount of hydrogen peroxide that's produced by binding to oxygen, making hydrogen peroxide. And so this causes stress on the system. and can cause mitochondrial biogenesis and mitophagy from mitophagy first, and then mitochondrial biogenesis as a result of that.

And so what methylene blue does is increase the amount of hydrogen peroxide that's produced by binding to oxygen, making hydrogen peroxide. And so this causes stress on the system. and can cause mitochondrial biogenesis and mitophagy from mitophagy first, and then mitochondrial biogenesis as a result of that.

And so I have seen some of this, but this is a very technical point, but what happens with these higher doses of methylene blue, when you make more hydrogen peroxide, you're also stimulating the body to produce more glutathione directly, which is our master antioxidant. And that's through a pathway called the Nrf2 pathway. And that stimulates, the hydrogen peroxide stimulates NRF2.

And so I have seen some of this, but this is a very technical point, but what happens with these higher doses of methylene blue, when you make more hydrogen peroxide, you're also stimulating the body to produce more glutathione directly, which is our master antioxidant. And that's through a pathway called the Nrf2 pathway. And that stimulates, the hydrogen peroxide stimulates NRF2.

That pathway produces more glutathione. But you have to make sure you have enough glutathione to be able to make it, right? Otherwise, you're going to be in a world of hurt.

That pathway produces more glutathione. But you have to make sure you have enough glutathione to be able to make it, right? Otherwise, you're going to be in a world of hurt.

And so when people start taking methylene, when they start getting detox kinds of symptoms, especially these higher doses, it's often because they have this hydrogen peroxide production without the amount of, without the capacity to make glutathione in response to that overall. So- but I don't want to forget your endurance questions. I got off on a tangent there.

And so when people start taking methylene, when they start getting detox kinds of symptoms, especially these higher doses, it's often because they have this hydrogen peroxide production without the amount of, without the capacity to make glutathione in response to that overall. So- but I don't want to forget your endurance questions. I got off on a tangent there.