Dr. Scott Sherr

Mitochondrial optimization is a very, very, very important piece, if not the foundational piece to what I do, because it dovetails the work I do in hyperbaric medicine. It's the foundation of the metabolomic work that we do in clinical practice as home health practitioners. And it has a significant amount to do with what we're doing at our for-profit company, Transcriptions.

Mitochondrial optimization is a very, very, very important piece, if not the foundational piece to what I do, because it dovetails the work I do in hyperbaric medicine. It's the foundation of the metabolomic work that we do in clinical practice as home health practitioners. And it has a significant amount to do with what we're doing at our for-profit company, Transcriptions.

to try to help people because 94% of the US population has mitochondria that doesn't work as optimally as it could. And so that's 6% are metabolically healthy. And so maybe some people have heard of that term like metabolically healthy. What does that mean? What metabolically healthy really means is that you're able to take those macronutrients and make energy from them.

to try to help people because 94% of the US population has mitochondria that doesn't work as optimally as it could. And so that's 6% are metabolically healthy. And so maybe some people have heard of that term like metabolically healthy. What does that mean? What metabolically healthy really means is that you're able to take those macronutrients and make energy from them.

And then also detox from the energy that you make. So the stuff we've been talking about here. So if you're not able to do any of those things optimally, then you have some element of mitochondrial dysfunction. So where do we have our most mitochondria? Dylan, this is a quiz question for you. Where do we have our most mitochondria per cell? Do you know? Yes. Your gut.

And then also detox from the energy that you make. So the stuff we've been talking about here. So if you're not able to do any of those things optimally, then you have some element of mitochondrial dysfunction. So where do we have our most mitochondria? Dylan, this is a quiz question for you. Where do we have our most mitochondria per cell? Do you know? Yes. Your gut.

Your gut has a lot, but there are more places. So number one place for men is in their sperm. Number one place for women is going to be in their ovaries and their eggs. And then after that, we have our brain, our heart, and our liver. And then our musculoskeletal system, of course. So if you have...

Your gut has a lot, but there are more places. So number one place for men is in their sperm. Number one place for women is going to be in their ovaries and their eggs. And then after that, we have our brain, our heart, and our liver. And then our musculoskeletal system, of course. So if you have...

brain fog, if you have concentration problems, if you have chronic fatigue, if you have exercise-induced fatigue, if you have detoxification issues, cardiac issues, these all are mitochondrial issues.

brain fog, if you have concentration problems, if you have chronic fatigue, if you have exercise-induced fatigue, if you have detoxification issues, cardiac issues, these all are mitochondrial issues.

If you are having a hard time getting pregnant, if you're female, or if you're having a hard time inseminating a female because you have sperm that don't work very well because your mitochondria there are not working well. So infertility, you mentioned this earlier with testosterone levels, this is also a mitochondrial issue significantly as well. However,

If you are having a hard time getting pregnant, if you're female, or if you're having a hard time inseminating a female because you have sperm that don't work very well because your mitochondria there are not working well. So infertility, you mentioned this earlier with testosterone levels, this is also a mitochondrial issue significantly as well. However,

In essence, if your mitochondria aren't working well, your cells aren't going to work well. And then there's all these cascades of things that happen as a result of that. So if you are looking at it from a gut perspective, which you mentioned, our gut microbiota, our bacteria...

In essence, if your mitochondria aren't working well, your cells aren't going to work well. And then there's all these cascades of things that happen as a result of that. So if you are looking at it from a gut perspective, which you mentioned, our gut microbiota, our bacteria...

in our gut are communicating with the mitochondria in our cells as well through these things called extracellular vesicles as well. And this is called interkingdom crosstalk, which means that our bacteria are communicating with these mitochondria in our cells to tell them what's going on and how to interact and how to work with the immune system and how to change DNA expression.

in our gut are communicating with the mitochondria in our cells as well through these things called extracellular vesicles as well. And this is called interkingdom crosstalk, which means that our bacteria are communicating with these mitochondria in our cells to tell them what's going on and how to interact and how to work with the immune system and how to change DNA expression.

And it's a very complicated system. But the lowest or the main common denominator here for most disease is mitochondrial dysfunction. So that doesn't mean that's the only thing you want to address. But oftentimes, if you think about what's causing mitochondrial dysfunction, it's the most common thing right now in the world, but especially in the US, is insulin resistance.

And it's a very complicated system. But the lowest or the main common denominator here for most disease is mitochondrial dysfunction. So that doesn't mean that's the only thing you want to address. But oftentimes, if you think about what's causing mitochondrial dysfunction, it's the most common thing right now in the world, but especially in the US, is insulin resistance.

So people that are obese and overweight, if you're insulin resistant, you have a higher risk of having metabolic dysfunction and then mitochondrial dysfunction. If you take medications that affect mitochondrial function as well, the most common one that's commonly used in longevity actually is metformin.

So people that are obese and overweight, if you're insulin resistant, you have a higher risk of having metabolic dysfunction and then mitochondrial dysfunction. If you take medications that affect mitochondrial function as well, the most common one that's commonly used in longevity actually is metformin.