Dr. Sergiu Pașcă

And it turns out that if you now make essentially a four-part disembloid that carries the mutation that causes excessive pain,

Now the sensory neurons are excessively active.

So they keep bursting with activity throughout.

And then we thought we're going to take it out.

And of course, in these patients, they can't fire.

It turns out that it's not true that they can't fire.

For some reason, there are probably other channels that are helping them compensate, but they fail to engage the rest of the pathway in a synchronized way.

So that's why we need the four parts.

And I think that's why assemblies generally are going to be very useful because there are emergent properties that are arising from the interactions of the cells at distance in the brain.

And likely many disorders, and of course, are very far from understanding complex disorders such as autism.

But certainly, these interactions, fault interactions at a distance in the circuits are probably going to be, you know, key to understanding the biology of these conditions and hopefully at one point kind of reversing them.

I think you can collect them at any time in principle.

I think you can still get them.

Okay.

For sure, it could be an argument.

So you have time, folks.

Right.

So it could be an argument made that, oh, the cells are going to be aging, so there are going to be some changes happening in those cells.

Yeah, they'll accumulate mutations.

Yeah, that could be an argument made about it.