Dr. Sergiu Pașcă

Right, because you would actually, you risk moving into another state.

But, you know, that may be possible at one point.

Right, right.

And it's true.

When you use the Yamanaka factors or a combination of them, because we've discovered afterwards that it's not just those factors that can do that.

There are combinations of other factors that can do the same.

So there are various combinations.

There is a lot of redundancy in that pathway.

And if you hit the right combinations in a cell at the right time, you can push it back in time.

Now, of course, the challenge is that that reprogramming is full in the sense that everything is going to be erased.

If the reprogramming

is done properly, directly, all the methylation, so all these methyl groups that you put across DNA that accumulate with age are going to be removed.

All the signatures are essentially removed, so the cell is truly rejuvenated as in the beginning.

And as you mentioned, perhaps you don't want to do that fully.

Can you do it in a way that is partial reprogramming, as some people refer to?

But certainly these are still like early days for that.

Certainly it's a possibility.

To modify, yeah, two individuals, two babies.

Yeah, to prevent, in this case, to prevent presumed transmission of HIV from the mother, which is not necessarily justified in that case.

Right.