Dr. Shawana Vali

It can be skin tightening modalities, radiofrequency ultrasound.

This is all you're comfortable with because you're not putting a needle in your face.

So you've got the virgin-style treatments and then you've got the non-virgin-style treatments.

And on the virgin, like you said, it's a controlled inflammation, it upregulates the medical layer of the skin, it tightens you, it cleans up any pigmentation and stuff like that, it works on different modalities.

Then you've got non-virgin where we might do intradermal exosomes.

We might inject hyaluronic acid mixed with exosomes.

We might use biologics such as PRF, PRP, your own growth factors.

We might use biostimulants such as PLLA or calcium hydroxyapatite to regenerate the dermis or even the bone on the periosteal level to tighten you.

So these are non-virgin because I'm using a foreign body into you, right?

So when it came to skincare and skincare formulation, there are only certain things that are licensed at a certain prescription strength that we're allowed to use.

But the key thing is here, when you're looking at an ingredient, you want to look at bioavailability.

Does this amount actually get to the end point?

Or does it go to first pass metabolism?

Does it just sit on my skin?

Does it actually get to that cell we're talking about, the fibroblasts or the melanin or the keratinocytes?

What cell does it get to and how much of the bioavailability actually gets there?

And then what does it actually do?

What was the outcome of it?

And I think that's the key thing.

I can name exosomes to you, they're exosomal vesicles.