Dr. Shebani Sethi
speaker
159 appearances
2 recordings
1 series
first heard Feb 2025
last heard Mar 2025
Dr. Shebani Sethi’s voice in public audio — every appearance, attributed to the second.
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For example, the conversion of neurotransmitter precursors like tryptophan you get from your diet into serotonin, which is the happy mood chemical. They're also involved in the production of a really important compound in the body called BDNF, BDNF means brain derived neurotrophic factor.
This is like miracle growth for your brain cells, increases neuroplasticity, neurogenesis, meaning the making of new brain cells and the connections between brain cells. Also bacteria can produce really important compound called short chain fatty acids. These are called postbiotics.
of these things are postbiotics right prebiotics fertilize good bacteria probiotics are the bacteria and postbiotics are the compounds produced by the bacteria that are bioactive molecules or metabolites that are produced by healthy gut bacteria and impact our bodies and brains now short chain fatty acids are one of the most important of these and why because they affect every level of our health regulating cancer metabolism inflammation and gut health but they also cross the blood brain barrier and they affect brain health by regulating neurotransmitter levels and they reduce
information, which again is at the root of all this mental health stuff. Are you feeling stressed, sluggish, or struggling with sleep? You might be low on magnesium, and trust me, it's a bigger deal than you think.
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Your body will thank you.
You might lose your job.
I wouldn't go to jail like Galileo, but you might lose your job.
Amazing.
When I heard about what you're doing, I just said the happy dance. I was like, and I've been telling everybody, I'm like, wow, finally, somebody's getting it where it counts. That's awesome.
Mm-hmm. It's quite extraordinary. And I don't know if you're aware of this, but right at Harvard, there is Uma Nadu, who has a whole department of nutritional psychiatry talking about the microbiome and the brain. And there's another physician who's been on my podcast at Stanford. They have a
department of metabolic psychiatry so it's starting to happen and more and more psychiatrists are becoming aware of the data because there is data there's a lot of literature now that supports this notion so when i when i look at sort of the mitochondria it's really about you know metabolism and energy and and and
And so I'd like you to sort of unpack how that actually connects to psychiatric diseases. Because, you know, I first heard this concept when I talked to Martha Herbert, who is a neurologist, and I think she's also worked in psychiatry, I might be wrong. who was treating autism. And she was doing brain scans on these autistic kids.
She saw their brains were swollen and inflamed on biopsies with these kids got killed on a car accident or something. And see these brains are just full of inflammatory cells and the immune cells, the white blood cells called the glia. And she also called what they have a metabolic encephalopathy. she said that autism is not a brain disorder, it's a systemic disorder that affects the brain.
And that's what I hear you saying, that psychiatric illness, for the most part, is a systemic disorder that affects the brain. And the causes can be many. It could be your diet, it could be your microbiome. But I was with a gentleman this weekend whose family was a Hungarian Jew whose family was killed in the Holocaust. He says, I don't know, 150 members of my family were killed in the Holocaust.
I don't know everybody's name. And I've lived in a constant state of trauma and stress my whole life. And, you know, I was like, wow, this is the epigenetics of this.
And Scientific American just came out with a paper, not a paper, but an article documenting some of the research in New York after 9-11 where they saw women who were pregnant when 9-11 happened, their children were incredibly affected by epigenetics.
the stress and trauma that happened to the mothers when they were pregnant and was registered in gene expression patterns and epigenetics and in cortisol levels and cortisol receptor function. And I was like, wow, this data is really coming along in this. So there's a lot of things that can affect it.
But often the psychiatric problems are so misdiagnosed and mistreated, honestly, and it creates so much suffering. And so what you're talking about is really a revolution.
Yeah, it's so true because I was reflecting on a guest we had on a previous podcast who's a pediatric neurologist, trained at Harvard, Oxford. She works at University of San Diego now. And she did brain imaging, functional MRI imaging of the brain in autistic kids and found they had energy problems, that mitochondrial energy deficits were evident in the brain of autistic kids.
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