Dr. Thaïs Aliabadi

The follicle stays in the ovary.

And one thing that they've noticed with PCOS patients, for whatever reason, their ovary is super sensitive to the LH.

It's like adding fuel to the fire.

And 20% to 30% of them actually ovulate, right?

But they don't always ovulate.

That's the problem.

And of the ones who ovulate, it gets worse.

Of the ones who, let's say, this brain pituitary ovary access is just partially disrupted,

Of the ones who ovulate, 40% of them, the embryo either doesn't form because the quality of the egg is bad, but also the environment is not ready for it.

So the progesterone, the uterine lining is not ready for it.

That's why these patients don't get pregnant.

It could be everything.

It comes to all the other pillars.

It could be the feedback.

It just sort of comes about.

Yes, it's genetic, and that's why I want to talk about it.

This is just the first pillar.

You saw just the first driving force is this brain pituitary ovary pathway that's completely disrupted, that most patients, 70% to 80%, don't even ovulate.

And of the ones who ovulate, the environment is not really good for the embryo.

So that's just the first pillar.