Dr. Will Bulsiewicz

Yeah. So, satiation, like feeling full, is an important concept these days, right? We have all seen the rollout of Ozempic and these other GLP-1 type agonists. What is this GLP-1 that we're talking about here? This is a hormone. It's a gut hormone already produced by your body, right? And makes you feel full.

Now I'm not sitting here and going to try to pretend that like what you eat is going to have the same effect on your body that a drug does. That's not what I'm trying to do here. But I want people to understand that here we exist where 95% of Americans, 95% are deficient in fiber. This is our most prevalent nutritional deficiency. And fiber is what actually leads to the release of GLP-1.

Now I'm not sitting here and going to try to pretend that like what you eat is going to have the same effect on your body that a drug does. That's not what I'm trying to do here. But I want people to understand that here we exist where 95% of Americans, 95% are deficient in fiber. This is our most prevalent nutritional deficiency. And fiber is what actually leads to the release of GLP-1.

GLP-1 is what exactly? GLP-1 is glucon-like peptide 1, which is a gut hormone, which is what Ozempic is. Ozempic is GLP-1. Okay. And it has these different effects on our body, including helping us to control our blood sugar and making us feel full.

GLP-1 is what exactly? GLP-1 is glucon-like peptide 1, which is a gut hormone, which is what Ozempic is. Ozempic is GLP-1. Okay. And it has these different effects on our body, including helping us to control our blood sugar and making us feel full.

Which is the reason why Ozempic is used for diabetes and for weight loss.

Which is the reason why Ozempic is used for diabetes and for weight loss.

So... First of all, we have to fully acknowledge that these drugs are highly effective. There is no doubt that they work. They're getting results. They're getting results. But what are the long-term effects of these? We have no clue. Right. We have no clue. We don't have the data yet to say what the long-term results of these are.

So... First of all, we have to fully acknowledge that these drugs are highly effective. There is no doubt that they work. They're getting results. They're getting results. But what are the long-term effects of these? We have no clue. Right. We have no clue. We don't have the data yet to say what the long-term results of these are.

What we do know with complete clarity is that if you stop using the drug, by the way, they're very expensive. They're very expensive. Thousands of dollars per month. Wow. Right? And are we ready to commit to doing this for the rest of our lives? Because when you come off of the drug, you go right back to where you were. Really? Yes. You rebound immediately.

What we do know with complete clarity is that if you stop using the drug, by the way, they're very expensive. They're very expensive. Thousands of dollars per month. Wow. Right? And are we ready to commit to doing this for the rest of our lives? Because when you come off of the drug, you go right back to where you were. Really? Yes. You rebound immediately.

So flip side though, I think it's important at the same time as we're having this conversation about Ozempic and these types of weight loss drugs. Again, like I'm not here to vilify them. Okay. But when we're doing that, instead of changing the way that we eat. The behaviors. Right. The problem that exists with this is like, yes, we can measure weight loss.

So flip side though, I think it's important at the same time as we're having this conversation about Ozempic and these types of weight loss drugs. Again, like I'm not here to vilify them. Okay. But when we're doing that, instead of changing the way that we eat. The behaviors. Right. The problem that exists with this is like, yes, we can measure weight loss.

And when people lose weight, there are different things that can certainly improve and they become more healthy. But is the only thing that matters for human health our weight? That is not the case. There is so much more to us as humans and our determinants of our health beyond just whether or not we're obese, skinny, or what our body habit is. And so we need to look at that bigger picture.

And when people lose weight, there are different things that can certainly improve and they become more healthy. But is the only thing that matters for human health our weight? That is not the case. There is so much more to us as humans and our determinants of our health beyond just whether or not we're obese, skinny, or what our body habit is. And so we need to look at that bigger picture.

The bigger picture is that when we optimize our diet, we have opportunities to improve ourselves metabolically, which includes improving our weight, which includes improving our blood sugar control. But we also have opportunities to prevent other diseases far beyond what Ozempic is capable of preventing.

The bigger picture is that when we optimize our diet, we have opportunities to improve ourselves metabolically, which includes improving our weight, which includes improving our blood sugar control. But we also have opportunities to prevent other diseases far beyond what Ozempic is capable of preventing.

So, the data are clear. That when we consume an ultra-processed diet, which in the United States today, 60% of calories are ultra-processed foods. So more than half. These are foods, by the way, that did not exist 100 years ago. Crazy. Right? So what we're describing was not possible for our great-grandparents.

So, the data are clear. That when we consume an ultra-processed diet, which in the United States today, 60% of calories are ultra-processed foods. So more than half. These are foods, by the way, that did not exist 100 years ago. Crazy. Right? So what we're describing was not possible for our great-grandparents.

There's no way they could have ate the diet that we currently eat because these foods did not exist. And our kids, 70% of calories in our kids come from ultra-processed foods. Wow. And there's no doubt that they cause a shift in the microbiome. It's a shift towards what we call dysbiosis. So it's the opposite of what we see when we eat a diverse diet.