Dr. Zachary Rubin

It regulates your sleep-wake cycle.

It can regulate your mood.

It also regulates your gastric acid secretion and aid with digestion.

So it's kind of a jack-of-all-trades, which also makes it difficult to navigate this space because a lot of the symptoms that people experience, they overlap.

And as we talk more about some of these conditions, we're going to start to learn more, but also be confused at the same time because there's so much overlap there.

Yeah.

This is not something that I was taught in medical school either.

And in my fellowship training, we do both allergy and clinical immunology.

That's when I started to learn a little bit more about it.

But also as much as I tell people, yes, I'm a pediatrician.

That's my first board certification as an allergist.

I take care of all ages.

So I do see a lot of women of all ages who will come to me with issues related to potentially MCAS, which we'll get into.

And that's where I really started to learn more about this potential, uh,

neuroendocrine immune kind of axis where a lot of the sex hormones are really connected to the immune system.

And so, as you say, the general rule of thumb is that estrogen, we're getting more and more data to look at how it's interacting with mast cells.

And so we know that estrogen can increase that activation.

It could also decrease the degradation of histamine.

So not only you're producing more, but it kind of slingers.

Exactly.