Eric Ravussin, Ph.D.

And I think, once again, these new studies from NIH, this Consortium of Nutrition for Precision Health, are going towards this direction of basically, you are right, the food frequency questionnaire is here every day for 10 days in this Module 1 of the study. But then there are these other ways. There is the remote photography system that you take a picture with your phone of the plates.

And I think, once again, these new studies from NIH, this Consortium of Nutrition for Precision Health, are going towards this direction of basically, you are right, the food frequency questionnaire is here every day for 10 days in this Module 1 of the study. But then there are these other ways. There is the remote photography system that you take a picture with your phone of the plates.

You have these cameras and all that. And I think that now I hope that we're not going to make policy only or policy or guidelines only based on the nutritional epidemiology, but also on studies basically testing some hypothesis related to what the nutrition epidemiology has shown.

You have these cameras and all that. And I think that now I hope that we're not going to make policy only or policy or guidelines only based on the nutritional epidemiology, but also on studies basically testing some hypothesis related to what the nutrition epidemiology has shown.

Yeah, I was one of the four PIs, but I was the one who drove the write-up and the design of the study and all that. Calorie was an important study. It was funded by the National Institute on Aging, and it was really the first attempt to look at the impact of caloric restriction on biomarkers of aging.

Yeah, I was one of the four PIs, but I was the one who drove the write-up and the design of the study and all that. Calorie was an important study. It was funded by the National Institute on Aging, and it was really the first attempt to look at the impact of caloric restriction on biomarkers of aging.

Now, don't ask me what are the biomarkers of aging because there's still a lot of discussion around that. If I tell you it's your fasting insulin going up with life, it's your VO2 max going down, it's not your gray hair or your lack of air or these kind of things. But anyway, you have some more sophisticated protein glycation and production of isoprostane and all that.

Now, don't ask me what are the biomarkers of aging because there's still a lot of discussion around that. If I tell you it's your fasting insulin going up with life, it's your VO2 max going down, it's not your gray hair or your lack of air or these kind of things. But anyway, you have some more sophisticated protein glycation and production of isoprostane and all that.

It's great that you asked the question because now there is a calorie legacy study, which is to follow up these people, but also there is a biorepository of all the plasma samples, muscle biopsies, fat biopsies at Duke, which was the coordinating center. And these samples are available, of course, with a request And the PI of that is Bill Kraus. You may know the name.

It's great that you asked the question because now there is a calorie legacy study, which is to follow up these people, but also there is a biorepository of all the plasma samples, muscle biopsies, fat biopsies at Duke, which was the coordinating center. And these samples are available, of course, with a request And the PI of that is Bill Kraus. You may know the name.

He's a cardiologist, but he's at Duke. And it's interesting that you ask that because one of my colleagues just published a paper in Science on a postdoc analysis of adipose tissue in these people before and after caloric restriction. He found a gene of interest. He's an immunologist.

He's a cardiologist, but he's at Duke. And it's interesting that you ask that because one of my colleagues just published a paper in Science on a postdoc analysis of adipose tissue in these people before and after caloric restriction. He found a gene of interest. He's an immunologist.

Deep Dixit is at Yale, and he really mined these transcriptomes from adipose tissue and found a gene which is related to the immune function and found that if you knock out this gene in mice, they are resistant to weight gain. This is like a calorie restriction mimetic, and they improve the immune function and all that. Yeah, your question is very appropriate. There are still samples available.

Deep Dixit is at Yale, and he really mined these transcriptomes from adipose tissue and found a gene which is related to the immune function and found that if you knock out this gene in mice, they are resistant to weight gain. This is like a calorie restriction mimetic, and they improve the immune function and all that. Yeah, your question is very appropriate. There are still samples available.

Of course, they become less and less available or more and more difficult. I'm just digging in some of the samples that we had to send to somebody at UT Southwestern because he has a new molecule that he would like to test before and after weight loss in non-obese people. But the goldmine of these studies is really to be able to bank biosamples.

Of course, they become less and less available or more and more difficult. I'm just digging in some of the samples that we had to send to somebody at UT Southwestern because he has a new molecule that he would like to test before and after weight loss in non-obese people. But the goldmine of these studies is really to be able to bank biosamples.

We all bank the data and the results, but the biosamples, it's very, very important.

We all bank the data and the results, but the biosamples, it's very, very important.

First of all, I became interested in caloric restriction because of, I don't know if you remember, Peter, Biosphere 2.

First of all, I became interested in caloric restriction because of, I don't know if you remember, Peter, Biosphere 2.