Eric Ravussin, Ph.D.

And then it takes days to basically have a matching of your RQ to the FQ, which means you oxidize what you eat. Whereas if you do the contrary, you increase carbohydrate, it takes one day. And that's why I still believe, and back in Switzerland, we did this study where we were giving extra fat to as LCT, long-chain triglyceride, or MCT, because the MCTs are oxidized quicker.

And then it takes days to basically have a matching of your RQ to the FQ, which means you oxidize what you eat. Whereas if you do the contrary, you increase carbohydrate, it takes one day. And that's why I still believe, and back in Switzerland, we did this study where we were giving extra fat to as LCT, long-chain triglyceride, or MCT, because the MCTs are oxidized quicker.

And we found that, again, the culprit is always the fat. And we are very good at matching carbohydrate oxidation to carbohydrate intake. Very good, it's very difficult. First of all, you have what? 500 grams of glycogen stores. 100 in the liver, 300 to 500 in the muscle. That's all. It means if you have a lot of carbohydrate, that's a huge signal. And protein, the same thing.

And we found that, again, the culprit is always the fat. And we are very good at matching carbohydrate oxidation to carbohydrate intake. Very good, it's very difficult. First of all, you have what? 500 grams of glycogen stores. 100 in the liver, 300 to 500 in the muscle. That's all. It means if you have a lot of carbohydrate, that's a huge signal. And protein, the same thing.

You know how difficult it is to build up your muscle mass or your protein mass in the body by just eating more protein. You have to exercise or you have to take anabolic steroids or whatever. But the fat is the one which is not regulated. That's why I still have this problem with the carbohydrate insulin model. It works. Let's say there was a slight increase in energy expenditure.

You know how difficult it is to build up your muscle mass or your protein mass in the body by just eating more protein. You have to exercise or you have to take anabolic steroids or whatever. But the fat is the one which is not regulated. That's why I still have this problem with the carbohydrate insulin model. It works. Let's say there was a slight increase in energy expenditure.

It seems to work for weight loss. It's better with a ketogenic diet than with a low-fat diet. But in your entire life, I don't think it works. And piling the fat, I mean, you have done some of that.

It seems to work for weight loss. It's better with a ketogenic diet than with a low-fat diet. But in your entire life, I don't think it works. And piling the fat, I mean, you have done some of that.

I'm with you, and I think that we are now in the era of precision medicine or personalized medicine, and I think that this is what the NIH is embarking on when they do this Nutrition for Precision Health program.

I'm with you, and I think that we are now in the era of precision medicine or personalized medicine, and I think that this is what the NIH is embarking on when they do this Nutrition for Precision Health program.

When they do this study that I'm also a PI of a clinical site, which is molecular transducers of physical activity, to look at, in lieu of your genetic background, your environment, your socio-economical status, one size does not fit all. We have the dietary guidelines. They are applied for the entire nation.

When they do this study that I'm also a PI of a clinical site, which is molecular transducers of physical activity, to look at, in lieu of your genetic background, your environment, your socio-economical status, one size does not fit all. We have the dietary guidelines. They are applied for the entire nation.

And they tell you, you know, every time it's the Mediterranean diet or the DASH diet, which are the best and all these kind of things, but not for all. And I think that this is where we are going to have a huge development. It's to go

And they tell you, you know, every time it's the Mediterranean diet or the DASH diet, which are the best and all these kind of things, but not for all. And I think that this is where we are going to have a huge development. It's to go

I don't think it's going to be individualized, but at least for groups of people having the same, you know, different strategies and restriction has to be one of that. But now how do you restrict? Do you restrict by public policies, by taxing things?

I don't think it's going to be individualized, but at least for groups of people having the same, you know, different strategies and restriction has to be one of that. But now how do you restrict? Do you restrict by public policies, by taxing things?

Yeah, you're correct. And I see that with this new study that we are doing. People, when you say the word diet, they think weight loss. They think something miracle is going to happen. And we tell them, no, no, we want to know what you eat in relationship with your health and your genetic makeup and your environment and all these kind of things. I'm with you on that.

Yeah, you're correct. And I see that with this new study that we are doing. People, when you say the word diet, they think weight loss. They think something miracle is going to happen. And we tell them, no, no, we want to know what you eat in relationship with your health and your genetic makeup and your environment and all these kind of things. I'm with you on that.

Now, I'm a little bit more pessimistic that I always say education is a major cornerstone of that, but we also are going to need to have public health policies. I mean, it's been done with trans fat. It's being done now in South America with black label on dangerous thing in ultra-processed food and all this kind of thing.

Now, I'm a little bit more pessimistic that I always say education is a major cornerstone of that, but we also are going to need to have public health policies. I mean, it's been done with trans fat. It's being done now in South America with black label on dangerous thing in ultra-processed food and all this kind of thing.