Ezra Klein

And I feel like we're in this place.

It's actually like really tender and tricky.

Should everyone get it?

I didn't mean to make it mandatory.

So I went on the lowest dose of Twizepetide, like two and a half milligrams.

And I did not have the experience that people in your survey had.

So on the one hand, it's like the most interesting drug or one of them that I've ever tried, you know, legal or non-legal, because I seem to be sensitive to it.

And all of a sudden, I just didn't want to eat, which is never an experience I've had before.

It was like living in somebody else's brain.

The way I've described it to people, I used a slot machine analogy earlier.

It's like being a gambler who loves slots and going up to a slot machine and pulling the thing and getting the three cherries and then nothing lights up.

It made me feel like that there was this level of experience that I hadn't even recognized I had, which was around desire.

Like I would taste something and it would be good or I'd smell something.

And I hadn't noticed that the thing, it would then trigger another feeling, which was desire because like the feelings were so connected for me.

But all of a sudden I would have that same experience and then the desire wouldn't trigger.

and I would walk by the candy bowl and not stop, or I would leave half the burrito on my plate, it was in a way revelatory.

The problem is it made me quite depressed.

And hedonic.

And whether that was because I wasn't eating enough or what was going on, but the thing where people report more energy and more focus and feeling cheerier, for me, it really dulled experience.

Well, and that's why I think it's interesting to bring in my own experience, because there is this whole thing where it's working on some kind of reward mechanism, too, on maybe dopamine.