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But the psychedelics, they have these remarkable results where people, instead of taking, you know, one a day for years and years and years, the MDMA-assisted psychotherapy trials, it's three pills total. And those... No longer adaptive habits become available for relearning, for updating to the current circumstances. And six months later, the underlying condition is resolved.

But the psychedelics, they have these remarkable results where people, instead of taking, you know, one a day for years and years and years, the MDMA-assisted psychotherapy trials, it's three pills total. And those... No longer adaptive habits become available for relearning, for updating to the current circumstances. And six months later, the underlying condition is resolved.

But the psychedelics, they have these remarkable results where people, instead of taking, you know, one a day for years and years and years, the MDMA-assisted psychotherapy trials, it's three pills total. And those... No longer adaptive habits become available for relearning, for updating to the current circumstances. And six months later, the underlying condition is resolved.

So what people describe with psychedelics is it's like it was 20 years of therapy in one day. And I think that our critical period idea really provides an explanation. It's not just that something is happening at the receptor level. that is rebalancing a biochemical imbalance. It's that thing that's happening is enabling a reconfiguration of all of the synapses that are relevant to the trauma.

So what people describe with psychedelics is it's like it was 20 years of therapy in one day. And I think that our critical period idea really provides an explanation. It's not just that something is happening at the receptor level. that is rebalancing a biochemical imbalance. It's that thing that's happening is enabling a reconfiguration of all of the synapses that are relevant to the trauma.

So what people describe with psychedelics is it's like it was 20 years of therapy in one day. And I think that our critical period idea really provides an explanation. It's not just that something is happening at the receptor level. that is rebalancing a biochemical imbalance. It's that thing that's happening is enabling a reconfiguration of all of the synapses that are relevant to the trauma.

And that is the cure. It's the reconfiguring that's the cure. It's the learning that's the cure.

And that is the cure. It's the reconfiguring that's the cure. It's the learning that's the cure.

And that is the cure. It's the reconfiguring that's the cure. It's the learning that's the cure.

This is probably the coolest part of this paper. There's this proportionality between the duration of the acute subjective effects of the psychedelics in humans. A.K.A.

This is probably the coolest part of this paper. There's this proportionality between the duration of the acute subjective effects of the psychedelics in humans. A.K.A.

This is probably the coolest part of this paper. There's this proportionality between the duration of the acute subjective effects of the psychedelics in humans. A.K.A.

The length of the trip in humans is proportional to the duration of the open state that we can induce of this social critical period in mice. So, for example, ketamine keeps the critical period open for, you know, two days and then, you know, by a week it's closed. Psilocybin and MDMA keep it open for two weeks and closed by three weeks. LSD keeps it open for three weeks, closed by four weeks.

The length of the trip in humans is proportional to the duration of the open state that we can induce of this social critical period in mice. So, for example, ketamine keeps the critical period open for, you know, two days and then, you know, by a week it's closed. Psilocybin and MDMA keep it open for two weeks and closed by three weeks. LSD keeps it open for three weeks, closed by four weeks.

The length of the trip in humans is proportional to the duration of the open state that we can induce of this social critical period in mice. So, for example, ketamine keeps the critical period open for, you know, two days and then, you know, by a week it's closed. Psilocybin and MDMA keep it open for two weeks and closed by three weeks. LSD keeps it open for three weeks, closed by four weeks.

And then there's sort of a rock star psychedelic, which most people haven't heard of, called Ibogaine. And that, the trip lasts anywhere from 36 to 72 hours. Wow. Okay. And Ibogaine reopens the critical period for at least four weeks. And we haven't tested the closure yet. We haven't found the time.

And then there's sort of a rock star psychedelic, which most people haven't heard of, called Ibogaine. And that, the trip lasts anywhere from 36 to 72 hours. Wow. Okay. And Ibogaine reopens the critical period for at least four weeks. And we haven't tested the closure yet. We haven't found the time.

And then there's sort of a rock star psychedelic, which most people haven't heard of, called Ibogaine. And that, the trip lasts anywhere from 36 to 72 hours. Wow. Okay. And Ibogaine reopens the critical period for at least four weeks. And we haven't tested the closure yet. We haven't found the time.

Yes, solidly matter and solidly vulnerable. So it's possibly a mistherapeutic opportunity, but it's also possibly a time when we could do great harm to people because they're suggestible. They're sort of vulnerable to information coming in the way that children are. And then we've

Yes, solidly matter and solidly vulnerable. So it's possibly a mistherapeutic opportunity, but it's also possibly a time when we could do great harm to people because they're suggestible. They're sort of vulnerable to information coming in the way that children are. And then we've