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Guruduth Banavar

đŸ‘€ Person
427 total appearances

Appearances Over Time

Podcast Appearances

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

RNA is the expression of your DNA, right?

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So if you have, as a human, you have approximately 22,000 genes.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So now you think about approximately 5% of those 22,000 genes being expressed at any given point in time, depending on what you're doing right now, you know, what you ate,

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

how you slept, whether you're stressed or not.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So that 5%, which 5% of your entire human genome is being expressed at a given point in time, that is super important.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

And if the wrong things are expressed, then you end up having chronic disease of different types.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So RNA is basically the dynamics of your biology.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

DNA is kind of like the static blueprint from which the RNA is derived.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

And it's the same thing for your microbiome.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So when I think about microbiome, like think about a bacteria, right?

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

A bacteria approximately has about 3,000 genes.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

Again, 5% or less of the 3,000 genes are expressed.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

And you know what?

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

All bacteria are not bad guys.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

Most of the time, bacteria tend to be good guys, but sometimes they express the bad genes depending on the environment they're found in.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So it's much more important for us to measure and analyze RNA than DNA.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

So when we realized this in Viome and we made the bet that RNA is going to be more important, that was back in 2016, 2017.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

Yeah.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

We were way ahead of everybody else.

Digital Social Hour
Guruduth Banavar : Why Your DNA Doesn’t Decide Your Health | DSH #1702

There's really nobody in the industry who measures RNA right now.