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Harlan Krumholz

👤 Person
313 total appearances

Appearances Over Time

Podcast Appearances

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

I've seen trying to educate people through the Internet to see if that helps.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And there was a publication about five years ago in The Lancet in trying to use strategies to educate the public to do these features.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

But generally, we only think about them now.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And in about a few months' time, if this has gone away, it will go in the basket again and disappear, won't it?

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And it will be put away.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And so there tends to be poor quality evidence informed by case control and cohort studies and a complete lack of randomised trials.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

Look, that was really interesting.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

The first thing is to say Peter Opshaw said experience of use of steroids in SARS.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

But it's interesting, the Lancet produced what I consider is a really important piece of evidence, a sort of rapid review, you like, of the evidence that does not support corticosteroid treatment.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And in there, there was one.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

One study that was about MERS.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

There were four studies I identified on SARS.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

They also cited the influenza and increased mortality.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

That's in a systematic review and a trial on RSV in treatment.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And basically across the board, steroids is a bad idea.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

And I think this is a really useful piece of evidence.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

That allows you to look at it and think, not just experience, this is an evidence base right now.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

The current best available evidence says don't use steroids in coronavirus unless it's for another indication, a clear indication, such as asthma or one of the other reasons to use it.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

Well, look, this is a really good example of evidence-based medicine.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

In the steroids, there's clinical experience that might say to use steroids.