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Harlan Krumholz

👤 Person
313 total appearances

Appearances Over Time

Podcast Appearances

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And I thank all the people who point them out to me.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And Simon pointed out last week I made a major error in terms of test sensitivity and specificity.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

Not difficult because often within these terms you make slight mental errors and get certain aspects wrong.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And what I got wrong was just the result from sensitivity.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

We talked about taking 1,000 people with a prevalence of antibodies of 5%, so 50 people in 1,000 have antibodies, 950 do not.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

The sensitivity of the test was 70%, therefore 35 people

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

out of the 50 will have the disease and test positive.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And importantly, 15 people with the disease will test negative under that seroprevalence and that result.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And I'm illustrating one of my major teaching points there is to not use the languages of false positives and false negatives and throw that in the bin and actually say what it means.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

It is the people without the disease who test positive.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

And if I'd have said it that way, it would have been correct.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

But by using the gobbledygook sometimes of EBM and test accuracy, I made an error.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

So sorry, folks.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

Gobbledygook of test accuracy.

Talk Evidence
Talk evidence covid-19 update - natural history of covid, include patients in guidelines

Goodbye from me.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

Yes, hi, I am Editor-in-Chief of BMJ Evidence-Based Medicine, Professor of EBM at the University of Oxford and a GP.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

Yes, hi, I am Editor-in-Chief of BMJ Evidence-Based Medicine, Professor of EBM at the University of Oxford and a GP.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

I agree.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

This is a very interesting time in the world of evidence-based medicine.

Talk Evidence
Talk Evidence - Building an evidence base for covid-19

As we're going to hear on the programme, you're going to have evidence from case reports.