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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Myrobacteria might be able to persist in the environment directly.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So they might be able to grow in soil or in oceans.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It could be like living on Earth today without an immune system, or even like living on Earth today with an immune system, but where you could catch Ebola from trees or from your pet cat.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

To cause harm, all a myrobacterium needs to be able to do

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

is grow.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

How much would it cost to make Mirror Life from where we are today?

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

People estimate something like 500 million to a billion dollars would be sufficient.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

That motivates the need to have these discussions now.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I think at the moment, the marginal impact of an extra person working on Mirror Life is huge.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

You could probably become the expert in policy around Mirror Life in your country within a few weeks or months.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It's great to be here.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Thanks for having me.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, it might seem like a trivial difference, but actually this is a really fundamental break from normal biology.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So ever since the last universal common ancestor, four billion years ago of all life on Earth, all of our DNA has always been made up of right-handed building blocks, meaning that it makes double helix that twists to the right.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And mirror bacteria would have the opposite.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

They'd have DNA that twists to the left.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So introducing it to earth would be a bit like introducing an alien invasive species that nothing on earth has evolved to deal with.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

To take one specific example, our immune systems

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

need to be able to recognize pathogens when they get into the blood to be able to mount an effective response.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The way that it does that is through receptors that you could think of like gloves.

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