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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

These fix carbon directly from sunlight and they can grow with just achiral nutrients like nitrogen, phosphorus, sulfur, that sort of thing.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And one of the very common causes of death for these marine cyanobacteria is infection by phage.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So up to 50% of marine cyanobacteria die from phage infection.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So if you introduced a mirror cyanobacterium, it would have basically these huge advantages because it wouldn't be able to be infected by phage, but potentially none of the limitations on nutrient availability.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And so the population of marine mirror cyanobacteria might grow to be very large.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

If they're growing to be very large and nothing is eating them because they don't really give any nutritional value to the protists that usually consume them, then they might start to sink to the bottom of the ocean and fix more carbon.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And it's really unclear what would end up being limiting here.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So I'm not confident at all in what would happen, but it could be the case that they act as a massive carbon sink, taking a lot of CO2 out of the atmosphere.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, to me, it seems really difficult to kind of titrate the amount of CO2 that you'd be able to take out of the atmosphere in this way, because once you had this population of myrosinobacteria growing, they would be really difficult to control and they would start to evolve into into other things.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So you might think, couldn't we just control them with mirror phages that we make or something like that?

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But at that stage, there'll already be a lot of them around.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It'll be impossible to drive the population to zero.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So we might just overshoot by miles and end up in an ice age or something like that.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Okay, yeah.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Equally, that might not happen.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And we might end up, I don't know, killing loads of trees through mirror bacteria and releasing loads of carbon into the atmosphere.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So depending on the mirror bacterium that's being made, it could kind of go in different directions.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It's hard to be confident, but we can look at some existing diseases and how quickly they've been able to spread as examples.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So COVID, because people spread it through air travel, was on all inhabited continents within four months of the first case.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And more generally, the speed at which a pathogen is going to spread is dependent on how quickly the fastest moving host moves around.