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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The thing that you're thinking of is human germline editing, which is a different technology.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

What that demonstrates to me is that

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

a norm on its own that lets you go right up to the edge of being able to do something is not sufficient because you can't assume that people are always going to go along with a regulation or with a norm and so that means you need to draw lines earlier on that mean that if people cross those lines there's still space between where they are and the thing that you're worried about bad thing okay that makes a lot of sense thank you

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, I think there are.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So you can use conjugate vaccines to kind of trick the body into having a robust response against basically anything.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So you can use them to trick the body into making antibodies against cocaine.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

You could do the same potentially for mirror components.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And that's something that I think is worth exploring in some more detail.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

More generally,

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

physical countermeasures should be helpful against mirror bacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So as a kind of plan B backup, if prevention doesn't work, I do think investing in robust biodefense that's kind of threat agnostic could be very valuable and is something that people should think about doing.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

That might be the extreme.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But in the nearer term, things like PPE, biohardening, and possibly early warning systems, some of the things that Andrew Snyder-Beattie talked about on a recent podcast on 80,000 hours, I think many of those could help for a myelobacteria outbreak too.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

That's a really good question.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

A lot of the methods that we use to detect things use enzymes that wouldn't work for mirror life.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Because of the chirality of them.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Classic.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So PCR is an example here, which is used to kind of amplify DNA.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

We can actually already make all of the enzymes in DNA.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

PCR in the mirror form.