James Smith

I mean, maybe it will go in a bit, which might actually be the case with some of this, but it's not going to fit as well.

And that's kind of the fundamental issue.

The immune system isn't binary.

So just one part of the immune system working is not necessarily going to be enough.

And we know from human immune disorders that if one important part of the immune system breaks, then people will die in childhood.

MHC class 2 deficiency, patients that have this disease usually die before the age of 10.

About 40% of them die before the age of 10 unless they can get a curative bone marrow transplant.

And that's just one part of the immune system not working.

With a myrobacteria infection, that part is very unlikely to work, I think.

But also the adaptive immune system, the pattern recognition receptor binding is unlikely to work.

And again, there are disorders that mimic that.

So there's a disorder called MyD88 deficiency, which basically means that the pattern recognition receptor repertoire doesn't function properly.

And in patients that have that, something like 30% of them die before the age of two.

Well, we don't know for sure.

It's pretty hard to know because we haven't ever seen anything that's exactly like this.

But one way to think about it is kind of like weeds taking over a garden.

They're not like deliberately causing harm, but they're just growing and spreading and using up nutrients.

And eventually, if something is growing and spreading in your body, it's going to cause an issue.

One way that that might...

play out is with something that looks like sepsis.