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Jean Smith

๐Ÿ‘ค Speaker
108 total appearances

Appearances Over Time

Podcast Appearances

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

The estimate I've heard from people in the industry is that eggs will probably cost $100,000 to $200,000 at the start.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

There are many very wealthy women who desperately want biological children who will be willing to pay an incredible amount of money for just a few viable eggs made from their own cells.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Early prices for stem cell-derived eggs will likely be an order of magnitude more than egg freezing.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

And while I think that stem cell-derived eggs will eventually be cheaper than taking hormones and paying for a surgeon to extract them, that will take additional time.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Subheading.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Cells accrue genetic mutations over time.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

The cells from which we're planning to derive eggs accrue mutations over the course of your life.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

So the older you are at extraction, the more de novo genetic mutations they will have accrued.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

This is much less of a concern for normal oocytes because they have special mechanisms to prevent them from accruing mutation, eggs partially deactivate their mitochondria until they are ready to be matured, which cuts down on the number of mutations.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

But it is a much larger concern for blood stem cells like those that companies in the space plan to use to create these eggs.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Heading How do I actually freeze my eggs?

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

I'll write a more complete guide on this later, but you can actually freeze your eggs for relatively little money if you know where to go.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Clinics like CNY Fertility are about a third the price of a regular IVF clinic and have reasonably similar outcomes for procedures like egg freezing.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

including the cost of the retrieval, monitoring, medications, flights, and hotels this will usually come out to about $6,000 to $7,000 per retrieval, most of the variance comes from flight costs and the cost of routine monitoring like ultrasounds.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Storage fees generally run around $500 per year.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

The downside of CNY is the customer experience is worse than average, and there's much less hand-holding than the average clinic.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

They aren't known for being particularly good with tricky infertility cases either, so if you've had past IVF failures you may want to look elsewhere.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

If CNY doesn't work for you, I'd recommend using Baby Steps IVF to find a clinic.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

It provides ranked lists of the best clinics all over the United States, and it's completely free.

LessWrong (Curated & Popular)
"The optimal age to freeze eggs is 19" by GeneSmith

Two friends of mine, Sam Solarik and Roman Hawkson spent the last year and a half building this site.