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Kyle Harper

πŸ‘€ Speaker
See mentions of this person in podcasts
733 total appearances

Appearances Over Time

Podcast Appearances

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

And that's evolution.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

Actually, this is one of the cool things with ancient DNA.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

We've been able to, like, piece together at the, like, absolute molecular level the

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

The genetic changes that let it make this protein that like have this effect in fleas.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

It's really weird.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

It forms this biofilm in the gut of the flea that like chokes it and makes the flea feel like it's starving.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

And so the flea just starts feeding and feeding and feeding.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

And meanwhile, it's regurgitating bacteria.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

We can talk about zombies, but that's aβ€”we need to wind up for that.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

Okay, so one, fleaβ€”so the plague is vector-borne, and it's really, really good at, like, manipulating the fleas, and it's just evolution.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

Two, I said this before, but it's an animal disease.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

We're, likeβ€”

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

Collateral damage.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

We're totally irrelevant to the like really core evolutionary history.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

The plague just wants to infect rodents.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

Of course, I'm – it's not really like wanting to do this.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

The plague makes a living.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

It survives out there in burrowing rodent colonies.

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

We're like –

Dwarkesh Podcast
Why Rome Actually Fell: Plagues, Slavery, & Ice Age β€” Kyle Harper

I mean, it doesn't care at all.