Lee Cronin

It's a hard problem, but actually, if you look at it, so the best way to look at it, let's take a molecule. So if the molecule has... um, 13 bonds. First of all, take 13 copies of the molecule and just cut all the bonds. So take cut 12 bonds and then you just put them in order. Yeah. And then that's how it works. So, and you keep looking for symmetry and re or, or copies.

So you can then shorten it as you go down. And that becomes commentorily quite hard. Um, for some natural product molecules, um,

So you can then shorten it as you go down. And that becomes commentorily quite hard. Um, for some natural product molecules, um,

So you can then shorten it as you go down. And that becomes commentorily quite hard. Um, for some natural product molecules, um,

um it becomes very hard it's not impossible but we're looking at the bounds on that at the moment but as the object gets bigger it becomes really hard and but that's the bad news but the good news is there are shortcuts and we might even be able to physically measure the complexity without computationally calculating it which is kind of insane well how would you do that

um it becomes very hard it's not impossible but we're looking at the bounds on that at the moment but as the object gets bigger it becomes really hard and but that's the bad news but the good news is there are shortcuts and we might even be able to physically measure the complexity without computationally calculating it which is kind of insane well how would you do that

um it becomes very hard it's not impossible but we're looking at the bounds on that at the moment but as the object gets bigger it becomes really hard and but that's the bad news but the good news is there are shortcuts and we might even be able to physically measure the complexity without computationally calculating it which is kind of insane well how would you do that

Well, in the case of molecule, so if you shine light on a molecule, let's take an infrared, the molecule has each of the bonds absorbs the infrared differently in what we call the fingerprint region. And so it's a bit like, and because it's quantized as well, you have all these discrete kind of absorbences.

Well, in the case of molecule, so if you shine light on a molecule, let's take an infrared, the molecule has each of the bonds absorbs the infrared differently in what we call the fingerprint region. And so it's a bit like, and because it's quantized as well, you have all these discrete kind of absorbences.

Well, in the case of molecule, so if you shine light on a molecule, let's take an infrared, the molecule has each of the bonds absorbs the infrared differently in what we call the fingerprint region. And so it's a bit like, and because it's quantized as well, you have all these discrete kind of absorbences.

And my intuition after we realized we could cut molecules up in mass spec, that was the first go at this.

And my intuition after we realized we could cut molecules up in mass spec, that was the first go at this.

And my intuition after we realized we could cut molecules up in mass spec, that was the first go at this.

We did it with using infrared, and the infrared gave us an even better correlation, assembly index, and we used another technique as well in addition to infrared called NMR, nuclear magnetic resonance, which tells you about the number of different magnetic environments in a molecule, and that also worked out. So we have three techniques, which each of them independently gives us

We did it with using infrared, and the infrared gave us an even better correlation, assembly index, and we used another technique as well in addition to infrared called NMR, nuclear magnetic resonance, which tells you about the number of different magnetic environments in a molecule, and that also worked out. So we have three techniques, which each of them independently gives us

We did it with using infrared, and the infrared gave us an even better correlation, assembly index, and we used another technique as well in addition to infrared called NMR, nuclear magnetic resonance, which tells you about the number of different magnetic environments in a molecule, and that also worked out. So we have three techniques, which each of them independently gives us

The same or tending towards the same assembly index for a molecule that we can calculate mathematically.

The same or tending towards the same assembly index for a molecule that we can calculate mathematically.

The same or tending towards the same assembly index for a molecule that we can calculate mathematically.

Yeah.